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What are some big mysteries/conspiracies that you think will be solved in our lifetime (i.e., the next 30-50 years)?

2024.05.20 05:24 Quick-Supermarket-43 What are some big mysteries/conspiracies that you think will be solved in our lifetime (i.e., the next 30-50 years)?

submitted by Quick-Supermarket-43 to AskReddit [link] [comments]


2024.05.20 05:21 Jayden101244 Well this was cool to see! (Just happened, so after the shiny event was over. Also everyone shame @prestopuppet for not telling me about the shiny event

Well this was cool to see! (Just happened, so after the shiny event was over. Also everyone shame @prestopuppet for not telling me about the shiny event
Not sure if Lokix is any good, but I think it might be worth giving it a try!!
submitted by Jayden101244 to pokerogue [link] [comments]


2024.05.20 05:20 MiserablePromise4000 campanha de 0% a 99% de nex

oi gente tudo bem? eu to c um projeto de mestrar uma campanha de 0% a 99% de nex usando as missões prontas e só adicionar algumas coisas pra elas “se completarem” de alguma forma. queria pedir a ajuda de vcs pra resolver alguns problemas q eu tô tendo nesse projeto, a sequencia ate agr é essa:
é isso, se vcs tiverem dicas pra conectar as missoes prontas ou ideias pras missoes que estao faltando, vai ser de grande ajuda!
submitted by MiserablePromise4000 to OrdemParanormalRPG [link] [comments]


2024.05.20 05:19 darkmatter343 What happened to classic terrorist hunt?

It’s been a minute since I last played, maybe around a year so I decided to re-install R6 Siege this week.
I’ve been playing solo PvE or offline against the AI for years, and just enjoy the terrorist hunt mode of 30 bots.
Once the game downloaded (PC), I went in and looks completely different. There’s all these different modes etc, and so I went to custom game but for the life of me I can’t find out how to just play the old original terrorist hunt PvE offline. The only thing I could find in the practice menus was something similar, but the house map wasn’t one and I also couldn’t choose it. It also didn’t give me the option to choose the difficulty so I could face 30 guys.
Does the classic terrorist hunt offline mode still exist? And how the heck can I access it?
I use to play house 99% of the time, with 30 guys, offline and that’s what I’m looking for.
Thanks!
submitted by darkmatter343 to Rainbow6 [link] [comments]


2024.05.20 05:16 ITSMECONCEPT Currently my favorite cards!

submitted by ITSMECONCEPT to pokemoncards [link] [comments]


2024.05.20 05:15 Short_Algo $UBER Awaiting Short Signal based off 6 signals $4,653 net profit 7.71 profit factor 83% win rate on a 15-min chart. Free trial at https://www.ultraalgo.com/?afmc=46 #trading #stocks #investing #money

$UBER Awaiting Short Signal based off 6 signals $4,653 net profit 7.71 profit factor 83% win rate on a 15-min chart. Free trial at https://www.ultraalgo.com/?afmc=46 #trading #stocks #investing #money submitted by Short_Algo to StockTradingIdeas [link] [comments]


2024.05.20 05:14 hubb2001 Translation Status Update/Discussion - May 19

Previous thread
This is the weekly translation status update thread. Use this thread to discuss translation news, issues, titles you're looking forward to, etc.
Note: This is simply a mirror from 4chan's weekly thread on the /jp/ board. All credit goes to the user VNTS there. I'm simply copying and pasting for discussion sake here since some people can't access 4chan.
Entries in Bold have had changes since last week
Entries in itallics denote my own changes

Fan Translations

  • 12RIVEN -the Ψcliminal of integral- - 42% translated
  • Aiyoku No Eustia - In progress 100% TL patch leaked, project to continue, 100% Translated/edited/TLC
  • Akatsuki no Goei ~Principal-tachi no Kyuujitsu~ - 100% translated and edited, 70.11% through QA
  • Akatsuki no Goei ~Tsumibukaki Shuumatsuron~ - 100% translated, 42,368 lines edited (69.69%), 4,793 (7.88%) through QA
  • Axanael - "Overwhelming majority" of the text translated, including the main story, some side content remains, in need of editing
  • CHAOS;HEAD Love Chu Chu! - 70.54% translated, 22.70% edited
  • CHAOS;CHILD Love Chu Chu!! - 100% translated, 55.30% edited
  • Chusingura 46+1 - 36843/82770 (44.51%) lines translated, Kuranosuke route partial patch released
  • Dragon Knight 4 - 60% translated, playtesting also ongoing
  • Fate/Stay Night - Partial patch released with a new translation for Fate/UBW/9 days of HF
  • Haruka na Sora - Sora and Yahiro routes translated, Kozue 75% translated, Sora 90% edited
  • Honoo no Haramase Oppai Nyuu Doukyuusei ~Oppai mo Haramase! New Class Zen'in Harama-sensation!~ - Picked up, porting to Ren'Py
  • If My Heart Had Wings: Snow Presents - 100% translated, 100% edited
  • Jisatsu no Tame no 101 no Houhou - 17% translated
  • Junketsu Megami-Sama - 2nd Alpha patch released, Astarotte route finishing up
  • Kaseki no Uta - 100% translated, 4770/15389 (31%) edited
  • Ken ga Kimi - 58% translated
  • Koukan no Toriko-Tachi - Prologue, common, and Cuckold Play route translated, Swinging Route 35%, Yukari POV 40%
  • Kud Wafter - AA Version 23,835/31,579 (75.5%) Lines translated, 18+ Version 19,240 / 33,113 (58.1%) lines translated
  • Kusarihime ~Euthanasia~ - Translation finished, fully edited
  • Lover Able - 100% translated and edited, 9419/32258 lines approved (29.47%)
  • Lucky Star ~Ryouou Gakuen Outousai~ - episode 1 patch released
  • Maji de Watashi ni Koishinasai! A - Ryouken Route After - 2,647/3,494 (75.76%) lines translated
  • Maji de Watashi ni Koishinasai! A Plus Disk - Preparing files
  • Manakashi no Yuri wa Akaku Somaru - 66% translated
  • Miagete Goran, Yozora no Hoshi o - 1 of 4 routes translation finished for the restoration patch, Houkiboshi Hika 2 of 4 H-scenes translated
  • Miagete Goran, Yozora no Hoshi o: Interstellar Focus - 100% translated, 89.6% edited
  • Nursery Rhyme - 100% translated and edited, text insertion 100% complete, testing ongoing
  • Pure Pure - 100% translated, needs proofreading, partial patch released, all routes have been inserted
  • Sakura no Uta - Chapter I 30% translated
  • Sakura Wars 2 - Demo patch released, ADV, Battle, and "Long Day in the Theater" mode fully translated, disc 1 text inserted
  • Sen no Hatou, Tsukisome no Kouki - Both original and fan disc 100% translated, in need of editing
  • Shirotsume Yubiwa - 100% translated, 50% beta patch released
  • Shizuku - 120/197 script files translated, 20/197 edited
  • Taima Seiko Alice - 45% translated, 35% edited, 35% proofread, 1st partial patch out
  • Tenshi no Inai 12-gatsu - 100% translated, Editing ongoing
  • To Heart - 720/993 scripts translated, 200/993 edited
  • Tokimeki Memorial 2 - Being translated
  • Tokimeki Memorial Girls Side 4 - 55% translated
  • Tsui no Sora Remake - 100% translated and edited, finalization progressing
  • Umi kara Kuru Mono - 91/138 scripts translated
  • Ushinawareta Mirai o Motomete - 23243/35416 (65.6%) lines translated
  • Yosuga no Sora - Translation finished, editing and TLC ongoing, Total: TL 100% TLC 71% ED 55%, Common/Kazuha/Motoka/Sora routes fully edited

Official work

MangaGamer

  • The Pillagers of Raillore - Out of Beta
  • Ciconia - Phase 1 Released
  • Hadaka Shitsuji fandisc - Picked up
  • Rance 03 - 79% translated, 41% edited
  • Rance X - 94% translated, 5% edited
  • Luckydog1 - 100% translated and edited
  • Funbag Fantasy 4 - 84% translated, 80% edited
  • Eve of the 12th Month - 100% translated and 88% edited
  • DEAD DAYS - 100% translated and edited
  • Beat Valkyrie Ixseal - 88% translated and 81% edited
  • Welcome to a Sexy, Open World - 98% translated and 90% edited

JAST

  • Sisters: Last Day of Summer - June 3rd release
  • Sumaga- Slow progress ongoing
  • Katahane - Progress being made again
  • Django - Not actively making progress
  • Tokyo Hero Project - Translation finished, dealing with bugs
  • Machine Child - Still being developed
  • Yomegami: My Sweet Goddess - 100% translated
  • Yamizome Liberator - Picked up
  • Mojika: Truth Rears Its Ugly Head - Picked up
  • Djibril - 100% translated, in editing
  • Masquerade: Hell Academy - Through 1st QA pass, in 2nd QA pass

Sekai/Denpa

  • NEKO-NIN exHeart SPIN - In QA Testing, 2024 release
  • Happy Saint Sheol - 100% edited, 40% QA, Demo released
  • Harumade Kururu - Waiting on build
  • Rewrite+ Harvest Festa - 100% translated, 40% edited, Steam page up, 2024 release
  • Subete no Koi ni, Hanabata o. - 50% translated
  • Sumire - Picked up
  • Sanarara R - 100% translated and edited, waiting on build
  • Glass - Picked up
  • New Glass - Picked up
  • Karakara 3 - 100% translated and edited, 70% engine work
  • Yume to Iro de Dekiteiru - 100% translated, 35% edited
  • Zutto Mae Kara Joshi Deshita - 100% translated, in editing
  • A Maiden's Serenade - In Editing
  • Hoshizora e Kakaru Hashi 10% translated
  • Hoshizora e Kakaru Hashi AA - Announced
  • Akaneiro ni Somaru Saka - 50% translated
  • Hamidashi Creative - Announced
  • Inupara - In Development
  • Nekopara After La Vraie Familie - In Development
  • Raspberry Cube - Announced
  • Wagamama High Spec OC - In Translation

Nekonyan

  • Angel Chaos RE-BOOT!- Delayed after Steam rejection
  • Dracu Riot - Waiting on Build, Release date announcement on hold until after Angel Chaos
  • Melty Moment - 80% translated
  • Fureraba Complete edition - Vita exclusive content to be added to Fureraba a couple months after the fandisc release
  • Floral Flowlove - 100% translated, 70% edited, enging port ongoing
  • Kakenuke Seishun Sparking - 80% translated, 70% edited, QA started
  • Love, Elections, & Chocolate - 100% translated and edited, Engine port nearly finished, entering QA shortly
  • Love Love Love, Burning in my Heart! - 100% translated and 74% edited
  • Ready or Not: The Deadline is Coming! - 100% translated, 99% edited, waiting on build
  • Mysteries of the Heart: The Psychic Detective Case Files - 100% translated and edited, engine work in progress
  • Secret Project 2 - 100% translated and edited, queued for Unity port
  • Secret Project 3 - 100% translated and edited, 50% though QA

PQube

  • SINce Memories: Off the Starry Sky - Announced

VisualArts

Dualtail

Frontwing

  • Lilja and Natsuka: Painting Lies - July 25th release
  • Revue Starlight El Dorado - August 8th release
  • Everlasting Flowers - Where there is a will, there is a way - August 29th release date
  • Sharin no Kuni - Working to resolve remaining issues

Aksys

  • Radiant Tale -Fanfare- - June 27th release
  • Tales from Toyotoki: Arrival of the Witch - Summer release
  • Virche Evermore -EpiC: Lycoris- - Fall release
  • Despera Drops - 2025 release

Age titles

  • Kiminozo - Aiming for a Summer 2024 release

Fakku

  • Two Beasts Or Not To Beast!! - 2.0 version, editing in progress
  • Forbidden Ward - In Pre-Production

Saikey Studios (mix of official/unofficial)

  • The Reason For Your Smile - Steam page up, Happy and NTR routes translated
  • Toaru Hahaoya no Ayamachi ~Yukari Hen~ - 50% translated

HyoukanOpera

  • Knight Case Files - Trial released, upcoming release

MAGES. GAME

  • Corpse Party II - Darkness Distortion - 2024 release

Voltage Inc.

  • Project Code Kaleido Tower - 2024 release
  • Project Code Neon Mafia - 2024 release
  • Project Code Vampire Hunter - 2025 release

B-cluster

  • Re;quartz Raid - 2024 release

MediBang Inc.

  • Cocktail Magic - Upcoming release

Kamitsubaki Studio

  • KAMITSUBAKI CITY REGENERATE - Upcoming release

Dayu Zixun

  • Voice Love on Air - Upcoming release

Shiravune

  • AMANATSU ~Perfect Edition~ - Released
  • Destiny Star Girlfriend 2 - Q2 2024 release
  • Real Hentai Situation! 2 - 2024 release
  • NYO-NIN-JIMA -My New Life in Charge of a Tropical Island- - 2024 release
  • An Aunt After My Own Heart - 2024 release, rejected by Steam
  • Kara no Shoujo III - Announced
  • Sacrifice Villains - Announced

Dramatic Create

Kagura Games

  • Forsaken Quartet - Released
  • Yoru ga Kuru! -Square of the Moon- Remastered - 2024 release
  • Angel Tear: Goddess Betrayed - Upcoming release

Aniplex

  • Tsukihime -A piece of blue glass moon- - June 27th release
  • Fate/stay night REMASTERED - 2024 release
  • Hookah Haze - 2024 release
  • Tanetsumi no Uta - 2024 release

Spike Chunsoft

Love Lab

  • Ever Maiden - 2024 release

DLsite

  • Friendly lab - unlock(); - Upcoming release
  • Club Suicide - Picked up

Idea Factory

  • Cupid Parasite: Sweet and Spicy Darling - May 28th release
  • 9 R.I.P. - Fall 2024 release
  • Date A Live: Ren Dystopia - 2024 release

CRAFTWORK

  • Geminism - English version announced

Harukaze

  • Monkeys! - English release planned

Moonchime

  • Haunted Obachestra Vol.1 Awaking - Upcoming release

Alice In Dissonance

  • Fault Milestone 2 - Side Below - Upcoming release

G-mode

  • Shinjuku Soumei - Demo Released, May 24th release

MiKandi Japan

  • Libra of the Vampire Princess - All versions of the patches in testing

PRODUCTION PENCIL

  • Paradise Cleaning! -Tutor X Hypnosis- - Upcoming release

072 Project

  • Princess Paradise - 2024 release

F&C

  • NTR with hypnosis application - Upcoming release

Eroge Japan

Tensei Games

  • Unfaithful Wife: Ayano's "Netorare Report" - My gentle wife is fucking another man - - Q2 2024 release

GRAVITY GAME ARISE

  • Tokyo Psychodemic - Demo released, May 30th release

Dark Nyaa

  • Master & Succubi Hentai Lessons 2 - April release

MintLip

  • Him, the Smile & Bloom - August 8th release

Cherry Kiss

  • Cosplay Cumdump: Doing it Doujin Style - May 23rd release

Umesoft

submitted by hubb2001 to vns [link] [comments]


2024.05.20 05:13 Short_Algo $NSC Awaiting Short Signal based off 5 signals $9,999 net profit 5.13 profit factor 80% win rate on a 15-min chart. Free trial at https://www.ultraalgo.com/?afmc=46 #trading #stocks #investing #money

$NSC Awaiting Short Signal based off 5 signals $9,999 net profit 5.13 profit factor 80% win rate on a 15-min chart. Free trial at https://www.ultraalgo.com/?afmc=46 #trading #stocks #investing #money submitted by Short_Algo to StockTradingIdeas [link] [comments]


2024.05.20 05:13 PlashTheClashYT So i wanted to see if this Doise plush is like the pic show... Pray for me

So i wanted to see if this Doise plush is like the pic show... Pray for me submitted by PlashTheClashYT to PizzaTower [link] [comments]


2024.05.20 05:13 pleth0ra Anything of value worth grading?

Anything of value worth grading?
Have my binder of Pokemon cards when I was a kid. Granted if they are in decent condition, which would be worth grading
submitted by pleth0ra to PokemonCardValue [link] [comments]


2024.05.20 05:13 OppositeOpening2023 nível de escolaridade e progressão de salario

Oi pessoal, tenho 28 anos e estou a procura de profissões para me qualificar ano que vem e sair do salário minimo e algo me chamou muita a atenção, é a progressão salarial de profissões de nível técnico seja mecânico de automóveis, refrigeração, manutenção industrial. e o curso da área contábil, seja contador, tecnólogo em gestão financeira.
Devo mencionar que pesquisei os salários e requisições no indeed, e estou falando de salário de funcionário.
O salário do técnico se inicia ganhando 1 salário minimo podendo chegar com experiência de trabalho até 3 mil, se for CLT existe adicional periculosidade de 30%, ou seja a depender da região do pais o salário de um técnico pode chegar a quase 4k, e o nível de exigência, é praticamente o domínio do básico, sem CLT esse salário fica entre 2k e 2,5k, sem adicional periculosidade, o tempo de duração do curso vai de 1 a 2 anos.
As profissões da área administrativa como, contador, bancário, auxiliar administrativo, assistente financeiro e etc... todos se iniciam ganhando salário minimo, até ai ok, o problema que me chama a atenção é a dificuldade para se chegar num salário de 3 a 4k, para querer trabalhar em banco tem que ter cpa-10,20 e CEA, se quiser prosperar como contador tem que ter carteira CRC e um MBA em controladoria ou analise contábil ou outro, se não vc nao passa dos 2,5k talvez até menos. Os cursos tem duração de 2 a 6 anos se levar em conta as certificações.
Eu fiquei pasmo quando percebi isso. Como é possível alguém com um curso técnico de 1 a 2anos ter a mesma progressão de salário de alguém que faz uma faculdade, que custa caro, tanto em dinheiro como em tempo? e considerando que se vc quiser imigrar meio que de penetra o curso técnico de posssibilita mais oprtunidades.
por isso fico na duvida, será mesmo que vale a pena fazer contabilidade ou outra faculdade de carácter mais administrativo, tendo em vista essa progressão de salário?
para passar dos 3 a 4k com diploma nivel superior eu teria que fazer dupla jornada se nao não dá.
submitted by OppositeOpening2023 to conselhodecarreira [link] [comments]


2024.05.20 05:10 ResponsibleReply4336 Are there any placements that would explain why I struggle in having female friends or why they are always competing with me? Or maybe why they feel intimidated?

Are there any placements that would explain why I struggle in having female friends or why they are always competing with me? Or maybe why they feel intimidated? submitted by ResponsibleReply4336 to AskAstrologers [link] [comments]


2024.05.20 05:07 unplugedanddrugged 30 cents to $75. Not bad

30 cents to $75. Not bad submitted by unplugedanddrugged to sportsbetting [link] [comments]


2024.05.20 05:06 No-Ride-6979 My First Hydromod

My First Hydromod submitted by No-Ride-6979 to casio [link] [comments]


2024.05.20 05:02 Meatrition A Metabolome-Wide Mendelian Randomization Study Identifies Dysregulated Arachidonic Acid Synthesis as a Potential Causal Risk Factor for Bipolar Disorder

Conclusions
In conclusion, our study suggests that higher levels of ARA may reduce the risk of BPD. Preclinical models and randomized clinical trials are needed to rigorously assess a potential role for ARA supplementation (and other PUFAs) in facilitating BPD prevention and treatment, particularly in individuals who carry BPD risk alleles at the FADS1/2/3 cluster. More broadly, our findings also support potential avenues for precision health interventions focused on early-life nutrition to ensure that infants and children are receiving enough ARA and other PUFAs to support optimal brain development, which may also reduce the risk of BPD.
Discussion
This 2-sample MWMR study revealed 33 circulating metabolites associated with BPD, most of them lipids. Chief among these metabolites was ARA in its free form along with several complex lipids containing either an ARA or LA side chain. We showed that most of these metabolite associations were driven by genetic instruments at the FADS1/2/3 cluster, which encodes a family of fatty acid desaturase enzymes responsible for the desaturation of omega-6 PUFAs in the LA to ARA pathway as well as omega-3 PUFAs in the αLA to eicosapentaenoic acid to docosahexaenoic acid pathway (22). Taken together, these findings suggest that the conversion of LA into ARA by the FADS1/2/3 cluster genes may play a key role in BPD etiology. A potential role for PUFAs in BPD has been widely posited over the past decade, although attention has primarily been focused on omega-3 PUFAs such as eicosapentaenoic acid and docosahexaenoic acid (22). A key finding from this 2-sample MWMR study suggests that increased synthesis of ARA, an omega-6 PUFA, may lower BPD risk. Although the ARA pathway has previously been implicated in the pathophysiology of BPD (23), to our knowledge, ours is the first study to highlight a potential causal role. Additional work is required to uncover the relevant downstream mechanisms, although studies have shown that ARA plays a vital role in the central nervous system, both as a major phospholipid constituent of neuronal and glial cell membranes and as a signaling molecule (24). Given its presence in human milk, ARA is considered to be essential for infant brain development and is added to infant formulas in many countries (25). Therefore, ARA may exert an effect on BPD risk by affecting neurodevelopmental pathways, which would be consistent with contemporary views of BPD as a neurodevelopmental disorder (26). In children and adults, ARA can be sourced either directly from meat and seafood products or indirectly by de novo synthesis from dietary LA (e.g., nuts, seeds, oils) via the FADS1/2/3 cluster genes (21). Conversely, infants lack the ability to synthesize ARA from LA and so are completely reliant on human milk or formula for their ARA intake (27). Therefore, future studies to assess ARA supplementation as a potential preventive strategy for BPD may be warranted, particularly with children or infants with poor natural dietary sources of ARA. A GWAS of fatty acid levels in breast milk from >1000 Bangladeshi mothers revealed that the FADS1/2/3 cluster was the primary driver of fatty acid levels and that of the 33 fatty acids measured, ARA was the primary fatty acid influenced by this gene cluster (28). Specifically, the authors found that the sentinel variant at the locus, rs174556, was associated with a per major allele effect size of 17% higher ARA levels (28). This is a large effect, and so lower levels of ARA in human milk due to genetic variation at the FADS1/2/3 cluster could play a role in modulating BPD risk. The sentinel variant associated with ARA in breast milk is in moderate to high LD with the BPD sentinel rs174592 (r2 = 0.67, 1000 Genomes Project [European Super Population]), which suggests that the 2 signals do overlap. However, if the levels of ARA in breast milk were a driver of the BPD signal, then the mother's genotype at the FADS1/2/3 cluster would be more important than that of the infant. Thus, a hypothetical cross-generational effect like this would suggest that the FADS1/2/3 cluster exerts a larger effect on BPD risk than current data suggest. In this study, we have shown that the BPD GWAS signal at the FADS1/2/3 cluster is likely driven by PUFA metabolism, suggesting that ARA may be the primary effector. Although the liver is generally considered to be the central organ of PUFA metabolism, the FADS1/2/3 cluster genes are expressed widely across human tissues and cell types, including in the brain (29). Therefore, it is unclear whether this cluster impacts BPD risk via distal mechanisms either in the liver or another peripheral tissue or by local activity in the brain. A recent study using a Fads1/2 knockout mouse model of BPD showed that peripheral, but not central, Fads1/2 gene knockout was necessary to recapitulate the BPD-like phenotype, as evidenced by a loss of the phenotype after conditional knockout in the brain (30). ARA and other PUFAs are actively transported into the brain across the blood-brain barrier (31), and recent GWASs have uncovered genome-wide significant associations between variants at the FADS1/2/3 cluster and several brain imaging-derived phenotypes including cortical thickness and surface area (32,33). Taken together, this is all consistent with peripheral PUFA metabolism having the potential to impact central mechanisms. A major clinical implication of the associations observed here between circulating metabolites and BPD relates to the search for biomarkers. There are currently no clinically approved psychiatric biomarkers, although predictive modeling has been widely applied in attempts to identify biosignatures of different psychiatric disorders. For example, a recent study identified a lipid signature for schizophrenia that also translates to both BPD and major depressive disorder (34). High-resolution profiling of circulating PUFAs in psychiatric patients may therefore prove to be crucial in facilitating psychiatric biomarker discovery. There are several potential limitations to this study. First, although we observed an inverse correlation between the BPD and lithium response GSMR estimates across the 33 BPD-associated metabolites, the lithium response estimates were based on a GWAS of only 2039 patients with BPD (2). A potential role for these metabolites in modulating lithium response should therefore be considered suggestive at best, although several previous studies have shown that lithium and other mood stabilizers impact the ARA pathway in animals (35,36). Second, it is unclear to what extent patients from the BPD GWAS by Mullins et al. (5) who participated in this study had been prescribed lithium. Although MR studies are more robust to confounding from medication and other lifestyle factors than observational studies, it is possible that the signals detected in our study reflect a lithium-responsive BPD subtype. Therefore, additional studies to explore this in more deeply phenotyped participants are needed. Third, because our findings were based on GWASs of European participants, the extent to which they are applicable to other populations is unclear. However, the GWAS signal for BPD at the FADS1/2/3 cluster was originally identified in a Japanese population (37), which suggests that the relevance of our findings likely does extend beyond Europeans. Fourth, although we found little to no evidence to support a role for these 33 BPD-associated metabolites in other related psychiatric disorders, it is possible that they may be relevant for certain psychiatric subtypes. For example, the depression phenotype used in the Howard et al. (38) GWAS was very broad, and so MR studies utilizing future GWASs focused on specific depression subtypes that adhere to more uniform and clinically relevant diagnostic criteria may yield different results. Finally, our replication efforts were hampered by differential metabolomic coverage between the metabolomic discovery and replication datasets. Future studies should therefore focus primarily on replication and validation. Studies that apply the Metabolon HD platform and other high-resolution platforms to independent population cohorts will be crucial to enable comprehensive replication analyses. Moreover, the application of platforms with ever-increasing coverage of PUFAs will help to pinpoint the most relevant metabolites involved in BPD etiology. We propose that future validation studies should utilize the Fads1/2 knockout mouse model of BPD (30) discussed earlier. These mice may represent a suitable preclinical model to assess the efficacy of PUFA supplementation (including ARA) in treating BPD-related symptoms, thereby highlighting specific PUFAs for subsequent randomized clinical trials.
submitted by Meatrition to StopEatingSeedOils [link] [comments]


2024.05.20 05:02 Exciting_Mirror4667 Pharm question

I am fascinated by the pharmacological world and i have always wanted this question answered. Unfortunately for me my unique situation allows for the perfect time to ask away.
Is there a magic space between the pharmacy and prescribing physician where notes pass that the patient cannot see??
Context; I keep track (recommended by my prescribing physician) by counting 4wks. So every 4th Sunday (28 days exactly) i go to pick up my medication. I always call Friday to make sure they've received. They always say "call us tomorrow so we can put it in the system". I always do. Both times they confirmed the refill will. E available Sunday. Sunday rolls around and script goes from processing to delayed. I call thinking they are out of said medication (happens often). Then i am now told my prescribing physician requires 30 days.
This has never happened before. I've filled 7x previous to this and never had any issues (besides lack of inventory). I am determined to figure out why the sudden change and if someone put something in my file. I've checked my clinical summary and the refill notes are the same. Is there a space between what pharmacist and doctors see but patients cannot? I am just very confused and afraid I've inadvertently done something wrong.
Thank you!
Ps. I spoke to insurance and they said it was approved and filled this am.
submitted by Exciting_Mirror4667 to pharmacy [link] [comments]


2024.05.20 05:02 Super_Breakfast_9706 2mil buy orders queued at open and only 5,000 sell orders! Who's READYYYYYY

2mil buy orders queued at open and only 5,000 sell orders! Who's READYYYYYY submitted by Super_Breakfast_9706 to FFIE [link] [comments]


2024.05.20 05:01 marywagnerlangford Letters Oppose the Dysfunctional Characterization of Langford Council

In this Letters to the Editor section of the Times Colonist there are a couple thoughtful submissions in support of our responsible approach to city finances Re: “B.C. is plagued by dysfunctional municipal councils,” commentary, May 15.
https://www.timescolonist.com/opinion/letters-may-18-skip-the-insulting-language-langford-council-is-not-dysfunctional-dont-subsidize-e-bikes-with-tax-dollars-8766472
Here are my thoughts:
A high percentage tax increase is not a sign of dysfunction. The tax increase requires context.
In Langford, the tax increase simply indicates that Langford Council approved a budget that is significantly higher than last year. The math shows that comparing us to other municipalities in the region, we went from 4th lowest in 2023 to 7th out of 13 in 2024.
Interestingly, if you only look at our tax increase percentage of 15.6% compared to Colwood at 4.9% it's not clear that, in fact, taxes for a representative house in Langford (~53,000 people) are still lower than in Colwood (~22,000) people in 2024. Esquimalt with ~20,000 people has much higher taxes by over $900.
There are lots of things to consider when comparing municipal budgets. Some of the major factors that affected the budget this year include:
Fire Department (additional 9 firefighters as per Master Plan) 2.31%
Debt payment (internal capital borrowing) 1.67%
Police (RCMP) for 5 additional officers + one ME 2.31%
CPI on wages 1.37%
Maintenance Contracts (i.e. roads and parks maintenance) 1.16%
General Staffing 1.12%
Repairs and maintenance 0.87%
Community Safety and Municipal (Bylaw) enforcement staffing 0.60%
Greater Victoria Regional Library 0.53%
Royal Roads University initiatives 0.50%
Utilities and insurance 0.50%
West Shore Parks and Recreation Society 0.30%
Miscellaneous (net effect of increases and decreases of revenues and expenses) 2.91%
Reduced contribution to Equipment Replacement Reserve -1.10%
Non-market change (helping offset additional costs of growth) -4.17%
Debt servicing costs - Westhills owned YMCA building purchase 1.75%
No longer using the amenity fees for tax reduction, but rather using them for tangible amenities like sidewalks ~3%
The budget was deliberated in public meetings and went through proper democratic process. There is a lot of value and need behind some of the numbers to support our rapidly growing community.
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