Arthritis in the neck more condition symptoms
Glitch in the Matrix
2012.01.13 04:52 Glitch in the Matrix
"Eye-witness event(s) that cannot be explained with critical thinking." **Please read forum rules before posting**
2015.07.06 01:20 squidboots we diagnose your sick plants!
If you're wondering "What's wrong with my plant?", we will help you diagnose and treat it!
2010.02.10 01:02 TaraJane23 Hyperhidrosis
2024.05.20 05:02 Meatrition A Metabolome-Wide Mendelian Randomization Study Identifies Dysregulated Arachidonic Acid Synthesis as a Potential Causal Risk Factor for Bipolar Disorder
Conclusions
In conclusion, our study suggests that higher levels of ARA may reduce the risk of BPD. Preclinical models and randomized clinical trials are needed to rigorously assess a potential role for ARA supplementation (and other PUFAs) in facilitating BPD prevention and treatment, particularly in individuals who carry BPD risk alleles at the FADS1/2/3 cluster. More broadly, our findings also support potential avenues for precision health interventions focused on early-life nutrition to ensure that infants and children are receiving enough ARA and other PUFAs to support optimal brain development, which may also reduce the risk of BPD.
Discussion
This 2-sample MWMR study revealed 33 circulating metabolites associated with BPD, most of them lipids. Chief among these metabolites was ARA in its free form along with several complex lipids containing either an ARA or LA side chain. We showed that most of these metabolite associations were driven by genetic instruments at the FADS1/2/3 cluster, which encodes a family of fatty acid desaturase enzymes responsible for the desaturation of omega-6 PUFAs in the LA to ARA pathway as well as omega-3 PUFAs in the αLA to eicosapentaenoic acid to docosahexaenoic acid pathway (22). Taken together, these findings suggest that the conversion of LA into ARA by the FADS1/2/3 cluster genes may play a key role in BPD etiology. A potential role for PUFAs in BPD has been widely posited over the past decade, although attention has primarily been focused on omega-3 PUFAs such as eicosapentaenoic acid and docosahexaenoic acid (22). A key finding from this 2-sample MWMR study suggests that increased synthesis of ARA, an omega-6 PUFA, may lower BPD risk. Although the ARA pathway has previously been implicated in the pathophysiology of BPD (23), to our knowledge, ours is the first study to highlight a potential causal role. Additional work is required to uncover the relevant downstream mechanisms, although studies have shown that ARA plays a vital role in the central nervous system, both as a major phospholipid constituent of neuronal and glial cell membranes and as a signaling molecule (24). Given its presence in human milk, ARA is considered to be essential for infant brain development and is added to infant formulas in many countries (25). Therefore, ARA may exert an effect on BPD risk by affecting neurodevelopmental pathways, which would be consistent with contemporary views of BPD as a neurodevelopmental disorder (26). In children and adults, ARA can be sourced either directly from meat and seafood products or indirectly by de novo synthesis from dietary LA (e.g., nuts, seeds, oils) via the FADS1/2/3 cluster genes (21). Conversely, infants lack the ability to synthesize ARA from LA and so are completely reliant on human milk or formula for their ARA intake (27). Therefore, future studies to assess ARA supplementation as a potential preventive strategy for BPD may be warranted, particularly with children or infants with poor natural dietary sources of ARA. A GWAS of fatty acid levels in breast milk from >1000 Bangladeshi mothers revealed that the FADS1/2/3 cluster was the primary driver of fatty acid levels and that of the 33 fatty acids measured, ARA was the primary fatty acid influenced by this gene cluster (28). Specifically, the authors found that the sentinel variant at the locus, rs174556, was associated with a per major allele effect size of 17% higher ARA levels (28). This is a large effect, and so lower levels of ARA in human milk due to genetic variation at the FADS1/2/3 cluster could play a role in modulating BPD risk. The sentinel variant associated with ARA in breast milk is in moderate to high LD with the BPD sentinel rs174592 (r2 = 0.67, 1000 Genomes Project [European Super Population]), which suggests that the 2 signals do overlap. However, if the levels of ARA in breast milk were a driver of the BPD signal, then the mother's genotype at the FADS1/2/3 cluster would be more important than that of the infant. Thus, a hypothetical cross-generational effect like this would suggest that the FADS1/2/3 cluster exerts a larger effect on BPD risk than current data suggest. In this study, we have shown that the BPD GWAS signal at the FADS1/2/3 cluster is likely driven by PUFA metabolism, suggesting that ARA may be the primary effector. Although the liver is generally considered to be the central organ of PUFA metabolism, the FADS1/2/3 cluster genes are expressed widely across human tissues and cell types, including in the brain (29). Therefore, it is unclear whether this cluster impacts BPD risk via distal mechanisms either in the liver or another peripheral tissue or by local activity in the brain. A recent study using a Fads1/2 knockout mouse model of BPD showed that peripheral, but not central, Fads1/2 gene knockout was necessary to recapitulate the BPD-like phenotype, as evidenced by a loss of the phenotype after conditional knockout in the brain (30). ARA and other PUFAs are actively transported into the brain across the blood-brain barrier (31), and recent GWASs have uncovered genome-wide significant associations between variants at the FADS1/2/3 cluster and several brain imaging-derived phenotypes including cortical thickness and surface area (32,33). Taken together, this is all consistent with peripheral PUFA metabolism having the potential to impact central mechanisms. A major clinical implication of the associations observed here between circulating metabolites and BPD relates to the search for biomarkers. There are currently no clinically approved psychiatric biomarkers, although predictive modeling has been widely applied in attempts to identify biosignatures of different psychiatric disorders. For example, a recent study identified a lipid signature for schizophrenia that also translates to both BPD and major depressive disorder (34). High-resolution profiling of circulating PUFAs in psychiatric patients may therefore prove to be crucial in facilitating psychiatric biomarker discovery. There are several potential limitations to this study. First, although we observed an inverse correlation between the BPD and lithium response GSMR estimates across the 33 BPD-associated metabolites, the lithium response estimates were based on a GWAS of only 2039 patients with BPD (2). A potential role for these metabolites in modulating lithium response should therefore be considered suggestive at best, although several previous studies have shown that lithium and other mood stabilizers impact the ARA pathway in animals (35,36). Second, it is unclear to what extent patients from the BPD GWAS by Mullins et al. (5) who participated in this study had been prescribed lithium. Although MR studies are more robust to confounding from medication and other lifestyle factors than observational studies, it is possible that the signals detected in our study reflect a lithium-responsive BPD subtype. Therefore, additional studies to explore this in more deeply phenotyped participants are needed. Third, because our findings were based on GWASs of European participants, the extent to which they are applicable to other populations is unclear. However, the GWAS signal for BPD at the FADS1/2/3 cluster was originally identified in a Japanese population (37), which suggests that the relevance of our findings likely does extend beyond Europeans. Fourth, although we found little to no evidence to support a role for these 33 BPD-associated metabolites in other related psychiatric disorders, it is possible that they may be relevant for certain psychiatric subtypes. For example, the depression phenotype used in the Howard et al. (38) GWAS was very broad, and so MR studies utilizing future GWASs focused on specific depression subtypes that adhere to more uniform and clinically relevant diagnostic criteria may yield different results. Finally, our replication efforts were hampered by differential metabolomic coverage between the metabolomic discovery and replication datasets. Future studies should therefore focus primarily on replication and validation. Studies that apply the Metabolon HD platform and other high-resolution platforms to independent population cohorts will be crucial to enable comprehensive replication analyses. Moreover, the application of platforms with ever-increasing coverage of PUFAs will help to pinpoint the most relevant metabolites involved in BPD etiology. We propose that future validation studies should utilize the Fads1/2 knockout mouse model of BPD (30) discussed earlier. These mice may represent a suitable preclinical model to assess the efficacy of PUFA supplementation (including ARA) in treating BPD-related symptoms, thereby highlighting specific PUFAs for subsequent randomized clinical trials.
submitted by Meatrition to StopEatingSeedOils [link] [comments]
In conclusion, our study suggests that higher levels of ARA may reduce the risk of BPD. Preclinical models and randomized clinical trials are needed to rigorously assess a potential role for ARA supplementation (and other PUFAs) in facilitating BPD prevention and treatment, particularly in individuals who carry BPD risk alleles at the FADS1/2/3 cluster. More broadly, our findings also support potential avenues for precision health interventions focused on early-life nutrition to ensure that infants and children are receiving enough ARA and other PUFAs to support optimal brain development, which may also reduce the risk of BPD.
Discussion
This 2-sample MWMR study revealed 33 circulating metabolites associated with BPD, most of them lipids. Chief among these metabolites was ARA in its free form along with several complex lipids containing either an ARA or LA side chain. We showed that most of these metabolite associations were driven by genetic instruments at the FADS1/2/3 cluster, which encodes a family of fatty acid desaturase enzymes responsible for the desaturation of omega-6 PUFAs in the LA to ARA pathway as well as omega-3 PUFAs in the αLA to eicosapentaenoic acid to docosahexaenoic acid pathway (22). Taken together, these findings suggest that the conversion of LA into ARA by the FADS1/2/3 cluster genes may play a key role in BPD etiology. A potential role for PUFAs in BPD has been widely posited over the past decade, although attention has primarily been focused on omega-3 PUFAs such as eicosapentaenoic acid and docosahexaenoic acid (22). A key finding from this 2-sample MWMR study suggests that increased synthesis of ARA, an omega-6 PUFA, may lower BPD risk. Although the ARA pathway has previously been implicated in the pathophysiology of BPD (23), to our knowledge, ours is the first study to highlight a potential causal role. Additional work is required to uncover the relevant downstream mechanisms, although studies have shown that ARA plays a vital role in the central nervous system, both as a major phospholipid constituent of neuronal and glial cell membranes and as a signaling molecule (24). Given its presence in human milk, ARA is considered to be essential for infant brain development and is added to infant formulas in many countries (25). Therefore, ARA may exert an effect on BPD risk by affecting neurodevelopmental pathways, which would be consistent with contemporary views of BPD as a neurodevelopmental disorder (26). In children and adults, ARA can be sourced either directly from meat and seafood products or indirectly by de novo synthesis from dietary LA (e.g., nuts, seeds, oils) via the FADS1/2/3 cluster genes (21). Conversely, infants lack the ability to synthesize ARA from LA and so are completely reliant on human milk or formula for their ARA intake (27). Therefore, future studies to assess ARA supplementation as a potential preventive strategy for BPD may be warranted, particularly with children or infants with poor natural dietary sources of ARA. A GWAS of fatty acid levels in breast milk from >1000 Bangladeshi mothers revealed that the FADS1/2/3 cluster was the primary driver of fatty acid levels and that of the 33 fatty acids measured, ARA was the primary fatty acid influenced by this gene cluster (28). Specifically, the authors found that the sentinel variant at the locus, rs174556, was associated with a per major allele effect size of 17% higher ARA levels (28). This is a large effect, and so lower levels of ARA in human milk due to genetic variation at the FADS1/2/3 cluster could play a role in modulating BPD risk. The sentinel variant associated with ARA in breast milk is in moderate to high LD with the BPD sentinel rs174592 (r2 = 0.67, 1000 Genomes Project [European Super Population]), which suggests that the 2 signals do overlap. However, if the levels of ARA in breast milk were a driver of the BPD signal, then the mother's genotype at the FADS1/2/3 cluster would be more important than that of the infant. Thus, a hypothetical cross-generational effect like this would suggest that the FADS1/2/3 cluster exerts a larger effect on BPD risk than current data suggest. In this study, we have shown that the BPD GWAS signal at the FADS1/2/3 cluster is likely driven by PUFA metabolism, suggesting that ARA may be the primary effector. Although the liver is generally considered to be the central organ of PUFA metabolism, the FADS1/2/3 cluster genes are expressed widely across human tissues and cell types, including in the brain (29). Therefore, it is unclear whether this cluster impacts BPD risk via distal mechanisms either in the liver or another peripheral tissue or by local activity in the brain. A recent study using a Fads1/2 knockout mouse model of BPD showed that peripheral, but not central, Fads1/2 gene knockout was necessary to recapitulate the BPD-like phenotype, as evidenced by a loss of the phenotype after conditional knockout in the brain (30). ARA and other PUFAs are actively transported into the brain across the blood-brain barrier (31), and recent GWASs have uncovered genome-wide significant associations between variants at the FADS1/2/3 cluster and several brain imaging-derived phenotypes including cortical thickness and surface area (32,33). Taken together, this is all consistent with peripheral PUFA metabolism having the potential to impact central mechanisms. A major clinical implication of the associations observed here between circulating metabolites and BPD relates to the search for biomarkers. There are currently no clinically approved psychiatric biomarkers, although predictive modeling has been widely applied in attempts to identify biosignatures of different psychiatric disorders. For example, a recent study identified a lipid signature for schizophrenia that also translates to both BPD and major depressive disorder (34). High-resolution profiling of circulating PUFAs in psychiatric patients may therefore prove to be crucial in facilitating psychiatric biomarker discovery. There are several potential limitations to this study. First, although we observed an inverse correlation between the BPD and lithium response GSMR estimates across the 33 BPD-associated metabolites, the lithium response estimates were based on a GWAS of only 2039 patients with BPD (2). A potential role for these metabolites in modulating lithium response should therefore be considered suggestive at best, although several previous studies have shown that lithium and other mood stabilizers impact the ARA pathway in animals (35,36). Second, it is unclear to what extent patients from the BPD GWAS by Mullins et al. (5) who participated in this study had been prescribed lithium. Although MR studies are more robust to confounding from medication and other lifestyle factors than observational studies, it is possible that the signals detected in our study reflect a lithium-responsive BPD subtype. Therefore, additional studies to explore this in more deeply phenotyped participants are needed. Third, because our findings were based on GWASs of European participants, the extent to which they are applicable to other populations is unclear. However, the GWAS signal for BPD at the FADS1/2/3 cluster was originally identified in a Japanese population (37), which suggests that the relevance of our findings likely does extend beyond Europeans. Fourth, although we found little to no evidence to support a role for these 33 BPD-associated metabolites in other related psychiatric disorders, it is possible that they may be relevant for certain psychiatric subtypes. For example, the depression phenotype used in the Howard et al. (38) GWAS was very broad, and so MR studies utilizing future GWASs focused on specific depression subtypes that adhere to more uniform and clinically relevant diagnostic criteria may yield different results. Finally, our replication efforts were hampered by differential metabolomic coverage between the metabolomic discovery and replication datasets. Future studies should therefore focus primarily on replication and validation. Studies that apply the Metabolon HD platform and other high-resolution platforms to independent population cohorts will be crucial to enable comprehensive replication analyses. Moreover, the application of platforms with ever-increasing coverage of PUFAs will help to pinpoint the most relevant metabolites involved in BPD etiology. We propose that future validation studies should utilize the Fads1/2 knockout mouse model of BPD (30) discussed earlier. These mice may represent a suitable preclinical model to assess the efficacy of PUFA supplementation (including ARA) in treating BPD-related symptoms, thereby highlighting specific PUFAs for subsequent randomized clinical trials.
2024.05.20 04:36 errantPixel Stiff, spasmodic rear leg kicking in a 14yo: Causes and treatments?
Hello, Our favourite doggo Roxy is a roughly 14yo rescue mutt, probably some mix of terrier and retriever. She is overall aging as well as we could hope, but the general signs of advancing age are there.
However, she's very recently started kicking out her back legs in a kind of spasmodic and seemingly partly involuntary way. Her legs shoot backwards very stiffly and fully straight, and she may alternate between them, but clearly struggles sometime to get one leg back underneath her before the other shoots back.
This is happening indoors, as well as indoors. It's caused her to pretty much crash to the floor on a number of occasions, as well as causing her to nearly fall down our back steps on another.
I've noticed Roxy's standing rear gait seems a little wider than usual on our linoleum and hardwood lately, and I'm wondering if these are all symptoms of just general loss of muscle tone and arthritis, or in particular if the leg spasms could be pointing to a more serious, acute, or degenerative condition?
I will be clear that I do intend to take her to the vet for a professional checkup this week, but since our vet got bought by a private equity firm we haven't been as stoked on the quality of care, and I'd first like to hear from anyone who's had similar experiences, so we're better prepared to ask better questions. <3
submitted by errantPixel to seniordogs [link] [comments]
However, she's very recently started kicking out her back legs in a kind of spasmodic and seemingly partly involuntary way. Her legs shoot backwards very stiffly and fully straight, and she may alternate between them, but clearly struggles sometime to get one leg back underneath her before the other shoots back.
This is happening indoors, as well as indoors. It's caused her to pretty much crash to the floor on a number of occasions, as well as causing her to nearly fall down our back steps on another.
I've noticed Roxy's standing rear gait seems a little wider than usual on our linoleum and hardwood lately, and I'm wondering if these are all symptoms of just general loss of muscle tone and arthritis, or in particular if the leg spasms could be pointing to a more serious, acute, or degenerative condition?
I will be clear that I do intend to take her to the vet for a professional checkup this week, but since our vet got bought by a private equity firm we haven't been as stoked on the quality of care, and I'd first like to hear from anyone who's had similar experiences, so we're better prepared to ask better questions. <3
2024.05.20 04:01 INEEDTONSOFADVICE How much time to reapply after being medically withdrawn?
Hi,
Context 1, Early June
I was medically withdrawn from school (selective, large university) in September of 2022. It started, in early June of that year, with me having my first cold when I travelled for a weekend event, in three or four years, and the cold was so bad, I was so confused and tired I almost boarded the wrong flight home (like I walked down the bridge and almost entered the wrong plane to God knows where, until I turned around and a flight attendant had to give me like a very kind pep talk).
It started with a strep throat during that weekend, then I began to cough so hard I felt dizzy, and I didn't stop coughing until December of that year. It was the worst cold I've had in my life, and I think it was made worse by the additional focus on hygiene during COVID (face masks etc.), which might have weakened my imune system. It was my first time going out without wearing a mask, and I happened to catch a cold.
Context 2, Late June/July
When I returned, I was alone in my off campus apartment, my body would itch (and this didn't make sense because there aren't any insects like mosquitos or I guess even ants in this area since it's so arid), I would sweat when I slept in my air conditioned room, I would have to walk a mile from my off campus apartment in the Arizona like heat and climate of July and August while having a cold. When I entered my over-cooled central AC apartment (I would have to leave windows and doors open to make it warmer) from the 95+ degree weather (I'm from a cold area of the country, but I grew up in several continents, and I'd never experienced this much heat), my stomach would begin to hurt from the instant change in temperature. I had to do really important work stuff that I couldn't miss, so I took different medications which caused my chest to hurt. I didn't want to go to the hospital because I was on the opposite side of the country, and I didn't know what would happen since I'm completely unfamiliar with how medical things are handled, and I had never stayed overnight in a hospital before, and I knew what I'm experiencing would probably warrant an extended stay.
Context 3, July/August
I then stopped eating, sleeping, and drinking water. Someone began spam texting me implicitly illicit texts (I would block the number, but another one would appear from another number, so like a dozen different numbers, and the texts weren't like a bot or automated, it would include photos and mention things I did recently e.g. go to the bar, it didn't ask for money or to download an app, it felt like someone I could have met or known irl was harassing me, perhaps as just a joke), and I barely give my number out and change it around once a year, so I was just so upset someone I knew gave my number to someone, or is doing this. Because of the delirium from the cold, I the began to send like weird (but not in any way, threatening or harassing, texts to mostly my friends who also attended the school) to figure out who gave my number or was behind the harassing texts. I had also experienced another issue with on campus, irl, harassment from a previous roommate that I had to report to campus safety multiple times, and I guess perhaps just because of the delirium, considering the digital harassment, I had become super persistent about my physical harassment that occurred just the semester before, and then an academic dean seriously offered to help, but then this led to a meeting with several deans. A day after this meeting, I emailed one of the deans to say that I am crying, and I was emailed at 8am to do a pysch evaluation at 11am in the morning. Because I hadn't slept the night before, and I had a feeling this would be a consequential meeting, in addition to having to walk 1 mile in the afternoon heat to this meeting, I asked to reschedule and then I was told no. Then I was sent a Maxient involuntary medical withdrawal letter.
Context 4, Now
I've been to about half a dozen pysch doctors (even one that's a lecturer at a leading medical research university), and about four therapists, since, and I haven't been diagnosed with anything definitively. My current therapist who is a former (or current) professor in psychology, and I've met with since late November of 2023, still doesn't have a diagnoses. I present extremely well, and I'm usually more social and normal than most people, so I guess you would have to look really deep to find something. I know that I probably have a sleep issue, so after meeting with a sleep doctor, I'm trying to setup a sleep study. In the meantime, I've been prescribed medication to combat day time sleepiness. Other related medical issues include the fact that my dad has Cushing syndrome, and I'm pretty confident I have it, or at least a cortisol issue (I have the visible/physical signs, as well as persistent high blood pressure, and other symptoms). Then, I also have several skin issues, that I'm also treating as well.
To be extremely honest, I'm kind of grateful I experienced this because I understand my body more, and how to seek help when my body is overwhelmed. Also, I kind of knew there would be an job crisis issue in April of 2022 since interest rates were rising and it would lead to less investments, therefore less jobs, so I've kind of enjoyed using this time to relax, travel, and learn new things. However, I'm starting to become anxious that I won't be able to return at all.
Question
Which leads to the question and title of my post, do time limits on withdrawals or leaves of absence apply to medical withdrawals or leaves of absence? My grades are pretty good, and I have no disciplinary issues, so I can still transfer, but I would still like to get back in, to be extremely frank, I would like to get back in first before transferring (just to tie up some loose ends to make a stronger transfer application). The way the communication (emails) from the schools non academic deans are worded, it's being made to seem as if I can't return at all (unless I reapply through admissions/the common app) regardless of if a doctor clears me. The way the letter is worded, it seems like I need to be cleared by a medical professional. My advisor, whose a non-educational lawyer, said I would onyl be approved to return if I take medication for 6-12 months. An email with a non-academic dean said this as well.
submitted by INEEDTONSOFADVICE to AskAcademia [link] [comments]
Context 1, Early June
I was medically withdrawn from school (selective, large university) in September of 2022. It started, in early June of that year, with me having my first cold when I travelled for a weekend event, in three or four years, and the cold was so bad, I was so confused and tired I almost boarded the wrong flight home (like I walked down the bridge and almost entered the wrong plane to God knows where, until I turned around and a flight attendant had to give me like a very kind pep talk).
It started with a strep throat during that weekend, then I began to cough so hard I felt dizzy, and I didn't stop coughing until December of that year. It was the worst cold I've had in my life, and I think it was made worse by the additional focus on hygiene during COVID (face masks etc.), which might have weakened my imune system. It was my first time going out without wearing a mask, and I happened to catch a cold.
Context 2, Late June/July
When I returned, I was alone in my off campus apartment, my body would itch (and this didn't make sense because there aren't any insects like mosquitos or I guess even ants in this area since it's so arid), I would sweat when I slept in my air conditioned room, I would have to walk a mile from my off campus apartment in the Arizona like heat and climate of July and August while having a cold. When I entered my over-cooled central AC apartment (I would have to leave windows and doors open to make it warmer) from the 95+ degree weather (I'm from a cold area of the country, but I grew up in several continents, and I'd never experienced this much heat), my stomach would begin to hurt from the instant change in temperature. I had to do really important work stuff that I couldn't miss, so I took different medications which caused my chest to hurt. I didn't want to go to the hospital because I was on the opposite side of the country, and I didn't know what would happen since I'm completely unfamiliar with how medical things are handled, and I had never stayed overnight in a hospital before, and I knew what I'm experiencing would probably warrant an extended stay.
Context 3, July/August
I then stopped eating, sleeping, and drinking water. Someone began spam texting me implicitly illicit texts (I would block the number, but another one would appear from another number, so like a dozen different numbers, and the texts weren't like a bot or automated, it would include photos and mention things I did recently e.g. go to the bar, it didn't ask for money or to download an app, it felt like someone I could have met or known irl was harassing me, perhaps as just a joke), and I barely give my number out and change it around once a year, so I was just so upset someone I knew gave my number to someone, or is doing this. Because of the delirium from the cold, I the began to send like weird (but not in any way, threatening or harassing, texts to mostly my friends who also attended the school) to figure out who gave my number or was behind the harassing texts. I had also experienced another issue with on campus, irl, harassment from a previous roommate that I had to report to campus safety multiple times, and I guess perhaps just because of the delirium, considering the digital harassment, I had become super persistent about my physical harassment that occurred just the semester before, and then an academic dean seriously offered to help, but then this led to a meeting with several deans. A day after this meeting, I emailed one of the deans to say that I am crying, and I was emailed at 8am to do a pysch evaluation at 11am in the morning. Because I hadn't slept the night before, and I had a feeling this would be a consequential meeting, in addition to having to walk 1 mile in the afternoon heat to this meeting, I asked to reschedule and then I was told no. Then I was sent a Maxient involuntary medical withdrawal letter.
Context 4, Now
I've been to about half a dozen pysch doctors (even one that's a lecturer at a leading medical research university), and about four therapists, since, and I haven't been diagnosed with anything definitively. My current therapist who is a former (or current) professor in psychology, and I've met with since late November of 2023, still doesn't have a diagnoses. I present extremely well, and I'm usually more social and normal than most people, so I guess you would have to look really deep to find something. I know that I probably have a sleep issue, so after meeting with a sleep doctor, I'm trying to setup a sleep study. In the meantime, I've been prescribed medication to combat day time sleepiness. Other related medical issues include the fact that my dad has Cushing syndrome, and I'm pretty confident I have it, or at least a cortisol issue (I have the visible/physical signs, as well as persistent high blood pressure, and other symptoms). Then, I also have several skin issues, that I'm also treating as well.
To be extremely honest, I'm kind of grateful I experienced this because I understand my body more, and how to seek help when my body is overwhelmed. Also, I kind of knew there would be an job crisis issue in April of 2022 since interest rates were rising and it would lead to less investments, therefore less jobs, so I've kind of enjoyed using this time to relax, travel, and learn new things. However, I'm starting to become anxious that I won't be able to return at all.
Question
Which leads to the question and title of my post, do time limits on withdrawals or leaves of absence apply to medical withdrawals or leaves of absence? My grades are pretty good, and I have no disciplinary issues, so I can still transfer, but I would still like to get back in, to be extremely frank, I would like to get back in first before transferring (just to tie up some loose ends to make a stronger transfer application). The way the communication (emails) from the schools non academic deans are worded, it's being made to seem as if I can't return at all (unless I reapply through admissions/the common app) regardless of if a doctor clears me. The way the letter is worded, it seems like I need to be cleared by a medical professional. My advisor, whose a non-educational lawyer, said I would onyl be approved to return if I take medication for 6-12 months. An email with a non-academic dean said this as well.
2024.05.20 03:57 avantgardebbread horrible migraine(?) out of nowhere(?) with twitching
so 2 days ago, I had a migraine like i’ve never ever had before. I got them a couple years ago before I went gluten free for celiacs + I had a brain tumor I didn’t know about(cushings disease). I didn’t really think much of them though at the time, after a couple hours of a bad headache on one side and light sensitivity it was over. but this time was extremely different and I ended up in the er because it just freaked me out. the last week and a half i’ve had both pms + starting my period, and 5 straight days of rain that caused my fibro to flare up. i’ve also just been dizzy(normal w fibro) but I thought it could’ve been my edibles. so I tried to take a t break to see if it would help any. I also have orthostatic hypotension but i’ve had that looonnggg before anything else. I take an about 3mg edible with about 15mg cbd for sleep and chronic pain every night or else I will be up all night. I do get tension headaches when i’ve been under a lot of stress + weather changes.
but then the following evening I was walking around a store when I got the sudden urge to throw up, I get nauseous but rarely like that. I was like dry sweating and my head started hurting. something felt very off from my normal issues and I tried to rush home. about 4 minutes away from my apartment my eyes started rolling into my head, luckily I got home safely. but within about 20 minutes of being home after a small dinner(I thought it was just low blood sugar or something) my eyes just kept rolling into my head, my leg started twitching a bit, and it just was painful so I laid down. the eye thing kept happening and I kept getting flashing lights everywhere(which I get those every once I in whike accompanied by a slight headache and dizziness). then my left arm kept almost convulsing(?) and my hand kept going into a claw postion. I kept getting tingling and numbness mainly on my left side as well. I had a couple momenrs with my right shoulder too. all while this was going on it felt like I took a backseat in my own body like I wasn’t in control. my headache was mainly above my eyes and in the center of my forehead. it eventually swept itself to my left side of my head entirely and that definitely felt like a migraine. visual aura kept going on. eyes kept moving back and forth but I couldn’t open my left. I kept trying to call for my roommate but but I couldn’t speak. it was terrifying. the headache continued for a couple more hours.
the next day around the same time, the twitching started again with a little bit of the eye issues and extreme nausea. this time my left side just felt weaker but I could still walk and use my arms. the flashing lights came again so I ubered to the er. aboutwo hours into my visit I got the migraine mock tail with benadryl zofran and thorazine. it felt like the headache kept wanting to happen until I got those. it helped with everything about 20 minutes after I took the meds. so I got discharged with a referral to a neuro about 40 minutes after that. today, i’ve just felt weak in the arms and tired, but I did start my edibles again last night and haven’t had any symptoms except my usual neck pain (I sleep weird and i’m an artist), temple headache, and very little appetite.
I guess my question is could this have been thc withdrawal? could it have been masking the migraines? or just stress, period stuff, and weather changes? i’ve been having weird symptoms the last couple of months with more visual disturbances accompanied by episodes that just made me feel like I was going to drop on the floor, confusion, tingling on the back of my limbs, and fatigue. those days i’d rush home from school and immediately fall asleep for hours without eating dinner. neurological issues do also run in the family(migraines and my mom has fnd)
i’m sorry for the long post, i’m just concerned, confused, and exhausted. i’m not looking for a ton of medical advice as I am seeing a neurologist soon, just kinda looking for support and if there’s anything I can do in the meantime.
submitted by avantgardebbread to migraine [link] [comments]
but then the following evening I was walking around a store when I got the sudden urge to throw up, I get nauseous but rarely like that. I was like dry sweating and my head started hurting. something felt very off from my normal issues and I tried to rush home. about 4 minutes away from my apartment my eyes started rolling into my head, luckily I got home safely. but within about 20 minutes of being home after a small dinner(I thought it was just low blood sugar or something) my eyes just kept rolling into my head, my leg started twitching a bit, and it just was painful so I laid down. the eye thing kept happening and I kept getting flashing lights everywhere(which I get those every once I in whike accompanied by a slight headache and dizziness). then my left arm kept almost convulsing(?) and my hand kept going into a claw postion. I kept getting tingling and numbness mainly on my left side as well. I had a couple momenrs with my right shoulder too. all while this was going on it felt like I took a backseat in my own body like I wasn’t in control. my headache was mainly above my eyes and in the center of my forehead. it eventually swept itself to my left side of my head entirely and that definitely felt like a migraine. visual aura kept going on. eyes kept moving back and forth but I couldn’t open my left. I kept trying to call for my roommate but but I couldn’t speak. it was terrifying. the headache continued for a couple more hours.
the next day around the same time, the twitching started again with a little bit of the eye issues and extreme nausea. this time my left side just felt weaker but I could still walk and use my arms. the flashing lights came again so I ubered to the er. aboutwo hours into my visit I got the migraine mock tail with benadryl zofran and thorazine. it felt like the headache kept wanting to happen until I got those. it helped with everything about 20 minutes after I took the meds. so I got discharged with a referral to a neuro about 40 minutes after that. today, i’ve just felt weak in the arms and tired, but I did start my edibles again last night and haven’t had any symptoms except my usual neck pain (I sleep weird and i’m an artist), temple headache, and very little appetite.
I guess my question is could this have been thc withdrawal? could it have been masking the migraines? or just stress, period stuff, and weather changes? i’ve been having weird symptoms the last couple of months with more visual disturbances accompanied by episodes that just made me feel like I was going to drop on the floor, confusion, tingling on the back of my limbs, and fatigue. those days i’d rush home from school and immediately fall asleep for hours without eating dinner. neurological issues do also run in the family(migraines and my mom has fnd)
i’m sorry for the long post, i’m just concerned, confused, and exhausted. i’m not looking for a ton of medical advice as I am seeing a neurologist soon, just kinda looking for support and if there’s anything I can do in the meantime.
2024.05.20 03:50 Future-Cabinet-9502 Im thinking of killing myself but my mom says im being dramatic and my brother is just adding on to my thoughts
I (15f) am thinking of killing myself. To give some context, I was born in another country and my family has had to constantly move due to my dad’s job. This has led to me having to make new friends only to leave them behind or being bullied because I don’t fit in very easily. I have been choked, physically hurt and humiliated by many bullies I have had over the years. Many kids have not wanted to hang out with me due to my condition. I have rheumatoid arthritis in my knees which is a chronic inflammatory disorder that limits my physical activity and I constantly feel pain. As far as I’ve been told, there is no cure but it can be controlled. I’ve had to deal with this condition and pain since the age of 2. Because of my limited activity many friends of mine have left me because I can’t catch up. My family has supported me but I hate the fact that I have had to take many pills that have caused damage to my body, go through numerous procedures that either inject fluid or extract fluid from my knees, and having to do many types of treatments that don’t improve it. My parents always make me feel bad whenever I complain saying that there are kids with worse conditions. I understand what they’re saying but I can’t help the overwhelming thoughts. Another thing is that my dad puts to much pressure on me. Both of my parents grew up with a poor background, and my dad studied very hard to get to where he is now. Education is the most important thing to him above all else. I care about my education but my dad constantly pushes me too hard. When I didn’t get the grades he wanted he has called me a piece of shit, garbage and when we went on a walk he said something that has been in my head for a long time. We were talking about life and education when he said “ I hate useless children”. I know he wasn’t referring to me but hearing that made me even more afraid of disappointing him. He has also told me to learn languages especially my native tongue( Spanish). I often have a hard time making friends because he has told me many times that it’s better to be alone and those around me are to use, those who are dumb and useless can be disposed of. I now have a mixed mentality and many judge the way I think. I have tried so hard to please him and have become addicted to his approval. All these situations have caused me to often collapse on my bed and cry and have a fear of my dad’s disappointment and people leaving me which has caused me to be very jealous and possessive of my friends. I try to vent my feelings to my older sister but she’s often busy due to work, so I often keep my feelings bottled up and it feels like my heart gets heavier. Now my family has once again moved to another place and I’ve had to leave an amazing group of friends behind. It’s been a year and I still haven’t made any friends and have been threatened with violence by another classmate in my school. But I’ve realized that this relocation has now caused me to have thoughts of suicide. My arthritis has returned and it has now spread to my ankle and possibly other parts of my body. Every time I walk it feels like I’m walking on needles and it takes me awhile to stand up and walk since my legs have gotten weaker. Many people at my school have looked at me weirdly because of the way I walk or have gotten annoyed that I walk slowly. My brother adds on to my suicidal thoughts often calling me dumb when he doesn’t even study, I have better grades, manners and am able to speak 5 languages. He also physically hits me specifically on my knee and ankles knowing that I have arthritis and knowing that I am very sensitive to pain in those areas. He makes fun of my condition by saying that it doesn’t hurt and running in circles saying “I bet you can’t do this”. He has also told to kill myself when he catches me venting to myself. I’m older than him by 4 years but he has no respect for anyone in my family but my dad. My sister and I have been disciplined while brother gets away with many things. We have complained to our parents many times about him but my dad is too busy working and my mom talks to him but it doesn’t help especially when she is a little sexist and often babies him. At one point my mom and I have had an argument in the car and eventually I brought up that I have been having thoughts of suicide but she said I’m saying stupid things and being dramatic. I love my family and I know love they love me back and want the best for me but sometimes I feel left out . I often have hallucinations because of my anxiety and often feel like I don’t really belong in any community. This may seem like a dramatic vent from a teenager but I ask that you understand at least a little bit and not judge me. Thank you to those that have read this far and to those who have the same or a similar condition to mine I’m happy to except any recommendations of treatments I could do( diets, therapies, etc.). Even though I have these dark thoughts I want to keep looking on the bright side and maybe this situation will get better.
submitted by Future-Cabinet-9502 to TrueOffMyChest [link] [comments]
2024.05.20 03:40 MegaMoodKiller Wegovy (Ozempic) helped with my AS, it feels like a miracle 🥺
I really feel the need to share it even tho I cannot prove causation but if you’ve experienced the chronic pain of AS you know as well as I that if ANYTHING helped you would want to share it with someone so here I am. I have been in chronic pain & with my AS diagnosis for quite some time ~3 years. I quit work due to pain and even small tasks like doing the dishes are excruciating at times due to AS and an injury I was in. Well, I’m at my heaviest weight (a lot of which was gained due to chronic pain of AS and limited mobility) so I was prescribed Wegovy by my primary and guys- I feel like a new person🥹😭
Wegovy is similar to Ozempic but not the same- it helps regulate blood sugar like Ozempic but wegovy provides something called semaglutide to those who need it. Anyways, within 1-2 days of taking the med I noticed my entire body feels so much better. My chronic pain in the mornings is now almost gone and the inflammation I have is also greatly reduced and I’m only on a low dose of this med (.5) but will be increasing overtime since that’s how it works.
Today I did laundry for the first time in 6 MONTHS. This is something my partner usually has to do for me due to my horrible pain. This is how I know it’s real- I was HAPPY to do laundry! 🧺 This med reduced my inflammation more than anything I’ve been on before. I thought I was going crazy because I hadn’t even lost weight yet so I know that’s not why I’m feeling better, it was literally days after my first injection.
Why I’m sharing - while on the Reddit for wegovyweightloss I noticed multiple other people comment that it’s helped with their other inflammatory/autoimmune diseases like rheumatoid Arthritis, Hashimotos, AND osteoporosis! People are saying it’s helped them feel so good they no longer drink or take pain meds and their entire life has changed. This drug I used to judge people for taking has truly changed my life and others for things beyond weight. These cases are all self-claims but one girl even shared an article talking about semeglutide and these findings (this was a few weeks ago sry I cannot find it now).
I feel like a changed person with less pain, I cried this morning laying in bed because I forgot how bad I used to feel all the time and am just so grateful today only 3 weeks after starting this med.
I just wanted to add this here in case it helps someone else. If you’re overweight and have ever been curious about weightloss stuff this could be something that helps 2 birds with 1 stone like it did me🩷 I told my partner that even if I lost no weight this is worth it because I have quality of life again because it helped with OTHER symptoms for the first time in years. I hope this helps someone else like it did me.
submitted by MegaMoodKiller to ankylosingspondylitis [link] [comments]
Wegovy is similar to Ozempic but not the same- it helps regulate blood sugar like Ozempic but wegovy provides something called semaglutide to those who need it. Anyways, within 1-2 days of taking the med I noticed my entire body feels so much better. My chronic pain in the mornings is now almost gone and the inflammation I have is also greatly reduced and I’m only on a low dose of this med (.5) but will be increasing overtime since that’s how it works.
Today I did laundry for the first time in 6 MONTHS. This is something my partner usually has to do for me due to my horrible pain. This is how I know it’s real- I was HAPPY to do laundry! 🧺 This med reduced my inflammation more than anything I’ve been on before. I thought I was going crazy because I hadn’t even lost weight yet so I know that’s not why I’m feeling better, it was literally days after my first injection.
Why I’m sharing - while on the Reddit for wegovyweightloss I noticed multiple other people comment that it’s helped with their other inflammatory/autoimmune diseases like rheumatoid Arthritis, Hashimotos, AND osteoporosis! People are saying it’s helped them feel so good they no longer drink or take pain meds and their entire life has changed. This drug I used to judge people for taking has truly changed my life and others for things beyond weight. These cases are all self-claims but one girl even shared an article talking about semeglutide and these findings (this was a few weeks ago sry I cannot find it now).
I feel like a changed person with less pain, I cried this morning laying in bed because I forgot how bad I used to feel all the time and am just so grateful today only 3 weeks after starting this med.
I just wanted to add this here in case it helps someone else. If you’re overweight and have ever been curious about weightloss stuff this could be something that helps 2 birds with 1 stone like it did me🩷 I told my partner that even if I lost no weight this is worth it because I have quality of life again because it helped with OTHER symptoms for the first time in years. I hope this helps someone else like it did me.
2024.05.20 03:20 Dazartim 10y/o cat with extremely worrying behavior after flea medication and time in carrier
Cat, She's around 10 give or take 2 years, spayed, (very)longhair munchkin mix, 10-12lb(will weigh her shortly and update)
not really sure on the age because I rescued her from a blackberry bush behind the house I lived at at the time. When I caught her she was absolutely horribly infested with fleas and seriously underweight, probably wouldnt have made it much longer. I was able to get that all cleared up on my own with some flea meds and good food. (would have taken her in but had $0 because I was legally unable to work at the time). I was going to say she's been extremely skittish and fearful since I got her but that's not exactly the case. She typically lives 100% of the time in the bedroom and when I'm in here she will paw at me and bunt me constantly for attention. Unfortunately my other cat was raised alone for a long time and bullied her for quite a while. I got my dog around the same time as bully cat and he just passed away a couple of months ago, since then they have slowly started getting better with each other. They do still have spats when one of them goes to the tub to get water (I leave it running slightly because they love it and dont drink enough otherwise) and the other is already there.
So in the days before dog had to be put to sleep, I layed him down in the grass outside to enjoy the sun. I'm pretty sure that's where the fleas I've been fighting came from. I gave both cats liquid flea medicine between their shoulder blades almost a week ago now and the other one is fine, but the longhair is seriously scaring me. First, a day or two after giving the medicine, I come home and there are 7-8 piles of vomit with food on the bed. She seemed to be her usual self at the time but I saw her vomit twice more about 30min-1hr apart after that. No more vomiting since then. I am not sure but I think she probably also peed on the bed, something she's done in the past as a result of the other cat attacking her in the litter box. I waited until the next day to wash the mattress protector, sheets, blankets pillows etc thinking shed probably throw up/pee more. It's a king bed so she had plenty of un-vomited space to be in. I was a bit worried and checked the back of her neck where I applied the medication. Absolutely no trace of the crusty spot I'm used to seeing after applying this stuff. She was fighting me the whole time I was trying to apply it and as I said VERY long hair so I think I applied it too low and she was able to lick it off. (Only vomiting, no foaming at the mouth or drooling)
The next day I went to wash everything and didnt want her peeing or throwing up on the bare mattress so I put her in a cat carrier on the bedroom floor with a shirt over the front, towel on bottom, and some food and water. She was in there a total of 3 hours, unlikely absolute maximum of 4. She has zero carrier experience so was having a pretty sad time in there. When I put her in she was acting normal. I put the mattress protector, blankets and pillows back and let her out. Water dish had been knocked over into the food, and had definitely been like that for a while. She ran and hid under the bed or something when I let her out which I thought nothing of.
Next day, as far as I could tell, she spent the entire day laying in the doorway to the bedroom. This was odd but I was gone most of the day and couldn't really tell if she was literally not moving or had been back and forth from the bed. I found it unusual that she let me step over her without freaking out like she usually does.
Next day she is laying in the bathroom next to the toilet. I didn't worry too much at first but noticed she's not running away like she usually does when I walk in on her in the bathroom, or trying to get attention. Or really doing anything. Just laying there with her head on her paws. I figure she's just tired and being weird from the carrier. Worry is definitely growing at this point though.
Next day I realize it's been at least 24-36 hours since I've seen her in the bedroom, she's been laying on the bathroom floor the entire time. I'm out of the house for 14+ hours every day lately and I am not sure what she does when I'm not there though. She's acting very lethargic, haven't seen her eat or drink but I believe she has albeit a bit less than normal, isn't pushing into my hand when I pet her or seeking attention, opening her eyes 60-80% of normal, haven't heard her meow one time since the crate and she's usually talkative. What really freaked me out was as she was laying on the bathroom floor, bully cat walked right past her and didn't even look at her as she went to the tub. THAT made me start thinking emergency vet as this is Saturday around 4-5. I would have taken her already but I'm in a major financial bind and have no way to be sure I'd even have enough money to pay the vet when all is said and done. Even the minimum that they charge would be coming out of June rent. I'll absolutely take her if it is necessary but I don't want us all to lose our house if it's not.
Today I come home and bully cat is laying on the floor a foot from her in the bathroom. They have begrudgingly laid next to each other on the bed before because they both wanted to be with me, but never alone. I'm kind of freaking out now and am very unsure what to do because she really isn't having any symptoms other than the vomiting which has passed days ago and the lethargy. I've poked and prodded all over her and she's not hurt anywhere. Feels like it's possible she lost a pound but throwing up 10 times will do that to a cat I'm sure. Should mention almost all of the vomit had food in it. The food isnt suspect but I changed it and washed the bowl just in case. I've lifted her up and made her walk to see how she does and she can definitely was but doesn't seem to want to. I brought her back to the bed and set her down and she laid down where I put her. After sitting with her for 15ish minutes she did get up and relocate. Doesn't feel hot but I'm not exactly sure how to take a cats temp. The flea medication was a knockoff of advantage 2 called advecta with the same amounts of the same active ingredients. I've looked into symptoms of ingestion and what to do and everything I'm seeing lines up with the vomiting but not her current behavior. Every source I've checked has also said even if the cat does drink an entire tube of it, they'll likely be totally fine. So I've been trying not to worry but she just seems like she's either suddenly horrifically depressed/traumatized by the carrier, or something else is going on. If she had any other symptoms I would have already taken her in. It's currently Sunday and if she hasn't improved I'm going to take her in on Monday unless advised to watch her longer by someone qualified. As I said, vet bill will likely be at least half of and probably all of next months rent, if I can even pay it. I'm about to go to the store and get some wet food and maybe chicken to see if she will eat it. Thank you all for reading this book of a post and thank you for any advice you may have.
submitted by Dazartim to AskVet [link] [comments]
not really sure on the age because I rescued her from a blackberry bush behind the house I lived at at the time. When I caught her she was absolutely horribly infested with fleas and seriously underweight, probably wouldnt have made it much longer. I was able to get that all cleared up on my own with some flea meds and good food. (would have taken her in but had $0 because I was legally unable to work at the time). I was going to say she's been extremely skittish and fearful since I got her but that's not exactly the case. She typically lives 100% of the time in the bedroom and when I'm in here she will paw at me and bunt me constantly for attention. Unfortunately my other cat was raised alone for a long time and bullied her for quite a while. I got my dog around the same time as bully cat and he just passed away a couple of months ago, since then they have slowly started getting better with each other. They do still have spats when one of them goes to the tub to get water (I leave it running slightly because they love it and dont drink enough otherwise) and the other is already there.
So in the days before dog had to be put to sleep, I layed him down in the grass outside to enjoy the sun. I'm pretty sure that's where the fleas I've been fighting came from. I gave both cats liquid flea medicine between their shoulder blades almost a week ago now and the other one is fine, but the longhair is seriously scaring me. First, a day or two after giving the medicine, I come home and there are 7-8 piles of vomit with food on the bed. She seemed to be her usual self at the time but I saw her vomit twice more about 30min-1hr apart after that. No more vomiting since then. I am not sure but I think she probably also peed on the bed, something she's done in the past as a result of the other cat attacking her in the litter box. I waited until the next day to wash the mattress protector, sheets, blankets pillows etc thinking shed probably throw up/pee more. It's a king bed so she had plenty of un-vomited space to be in. I was a bit worried and checked the back of her neck where I applied the medication. Absolutely no trace of the crusty spot I'm used to seeing after applying this stuff. She was fighting me the whole time I was trying to apply it and as I said VERY long hair so I think I applied it too low and she was able to lick it off. (Only vomiting, no foaming at the mouth or drooling)
The next day I went to wash everything and didnt want her peeing or throwing up on the bare mattress so I put her in a cat carrier on the bedroom floor with a shirt over the front, towel on bottom, and some food and water. She was in there a total of 3 hours, unlikely absolute maximum of 4. She has zero carrier experience so was having a pretty sad time in there. When I put her in she was acting normal. I put the mattress protector, blankets and pillows back and let her out. Water dish had been knocked over into the food, and had definitely been like that for a while. She ran and hid under the bed or something when I let her out which I thought nothing of.
Next day, as far as I could tell, she spent the entire day laying in the doorway to the bedroom. This was odd but I was gone most of the day and couldn't really tell if she was literally not moving or had been back and forth from the bed. I found it unusual that she let me step over her without freaking out like she usually does.
Next day she is laying in the bathroom next to the toilet. I didn't worry too much at first but noticed she's not running away like she usually does when I walk in on her in the bathroom, or trying to get attention. Or really doing anything. Just laying there with her head on her paws. I figure she's just tired and being weird from the carrier. Worry is definitely growing at this point though.
Next day I realize it's been at least 24-36 hours since I've seen her in the bedroom, she's been laying on the bathroom floor the entire time. I'm out of the house for 14+ hours every day lately and I am not sure what she does when I'm not there though. She's acting very lethargic, haven't seen her eat or drink but I believe she has albeit a bit less than normal, isn't pushing into my hand when I pet her or seeking attention, opening her eyes 60-80% of normal, haven't heard her meow one time since the crate and she's usually talkative. What really freaked me out was as she was laying on the bathroom floor, bully cat walked right past her and didn't even look at her as she went to the tub. THAT made me start thinking emergency vet as this is Saturday around 4-5. I would have taken her already but I'm in a major financial bind and have no way to be sure I'd even have enough money to pay the vet when all is said and done. Even the minimum that they charge would be coming out of June rent. I'll absolutely take her if it is necessary but I don't want us all to lose our house if it's not.
Today I come home and bully cat is laying on the floor a foot from her in the bathroom. They have begrudgingly laid next to each other on the bed before because they both wanted to be with me, but never alone. I'm kind of freaking out now and am very unsure what to do because she really isn't having any symptoms other than the vomiting which has passed days ago and the lethargy. I've poked and prodded all over her and she's not hurt anywhere. Feels like it's possible she lost a pound but throwing up 10 times will do that to a cat I'm sure. Should mention almost all of the vomit had food in it. The food isnt suspect but I changed it and washed the bowl just in case. I've lifted her up and made her walk to see how she does and she can definitely was but doesn't seem to want to. I brought her back to the bed and set her down and she laid down where I put her. After sitting with her for 15ish minutes she did get up and relocate. Doesn't feel hot but I'm not exactly sure how to take a cats temp. The flea medication was a knockoff of advantage 2 called advecta with the same amounts of the same active ingredients. I've looked into symptoms of ingestion and what to do and everything I'm seeing lines up with the vomiting but not her current behavior. Every source I've checked has also said even if the cat does drink an entire tube of it, they'll likely be totally fine. So I've been trying not to worry but she just seems like she's either suddenly horrifically depressed/traumatized by the carrier, or something else is going on. If she had any other symptoms I would have already taken her in. It's currently Sunday and if she hasn't improved I'm going to take her in on Monday unless advised to watch her longer by someone qualified. As I said, vet bill will likely be at least half of and probably all of next months rent, if I can even pay it. I'm about to go to the store and get some wet food and maybe chicken to see if she will eat it. Thank you all for reading this book of a post and thank you for any advice you may have.
2024.05.20 03:03 seasonedzb Please Help Me. Doctors tell me I’m all fine.
Hello all, I’m hoping someone can shed some light on what’s going on with me.
Male 29 US
No medications, taking Vitamin D and B12
For the past few months I’ve been experiencing the following symptoms. Random pain in my left armpit/shoulder area right where my arm connects to my torso. Sometimes the pain will shoot down my arm to my fingertips. Recently I’ve developed new more alarming symptoms. I start yawning uncontrollably despite having plenty of sleep. At the same time as I’m yawing, my head will feel very “full” I feel pressure in the back on neck on the left side. The left side of my jaw will hurt. My ears pop. And I feel lost, confused, sometimes even like I’m disconnected i guess? I’ll have trouble understanding when someone is talking to me. It’s almost like I don’t feel present if that makes sense? All these symptoms happen at the exact same time. Meaning it’s either I’m feeling all of them OR I feel completely fine. I’ve even narrowed down when the symptoms start. When I wake up and I’m doing things around the house I feel completely fine, but the second I get into my car the symptoms all hit me like a truck and they don’t stop for the rest of the day. They will continue even when I get to work. The only time the symptoms will stop is if I’m actively engaged in something work related, conversation, or anything stimulating. This has been going on for about 3-4 months.
I don’t know who to turn to anymore, I just want some answers. SOMETHING to bring up to my PCP. Anything. I’ve been to 5 doctors, I’ve gone to the ER twice. Blood tests came back fine except for really low Vitamin D (which I’ve been working on). Had chest x rays and those were fine too. Everyone is telling me I’m fine, I’ve even tried more “non traditional” approaches like Asian teas, and shady chiropractors. Nothing is helping. Doctors are just saying it’s stress it’s stress. I’ve lived with stress my entire life. Why is this happening now? What can it be? What can I do? Somebody please help me because I feel trapped.
submitted by seasonedzb to DiagnoseMe [link] [comments]
Male 29 US
No medications, taking Vitamin D and B12
For the past few months I’ve been experiencing the following symptoms. Random pain in my left armpit/shoulder area right where my arm connects to my torso. Sometimes the pain will shoot down my arm to my fingertips. Recently I’ve developed new more alarming symptoms. I start yawning uncontrollably despite having plenty of sleep. At the same time as I’m yawing, my head will feel very “full” I feel pressure in the back on neck on the left side. The left side of my jaw will hurt. My ears pop. And I feel lost, confused, sometimes even like I’m disconnected i guess? I’ll have trouble understanding when someone is talking to me. It’s almost like I don’t feel present if that makes sense? All these symptoms happen at the exact same time. Meaning it’s either I’m feeling all of them OR I feel completely fine. I’ve even narrowed down when the symptoms start. When I wake up and I’m doing things around the house I feel completely fine, but the second I get into my car the symptoms all hit me like a truck and they don’t stop for the rest of the day. They will continue even when I get to work. The only time the symptoms will stop is if I’m actively engaged in something work related, conversation, or anything stimulating. This has been going on for about 3-4 months.
I don’t know who to turn to anymore, I just want some answers. SOMETHING to bring up to my PCP. Anything. I’ve been to 5 doctors, I’ve gone to the ER twice. Blood tests came back fine except for really low Vitamin D (which I’ve been working on). Had chest x rays and those were fine too. Everyone is telling me I’m fine, I’ve even tried more “non traditional” approaches like Asian teas, and shady chiropractors. Nothing is helping. Doctors are just saying it’s stress it’s stress. I’ve lived with stress my entire life. Why is this happening now? What can it be? What can I do? Somebody please help me because I feel trapped.
2024.05.20 03:02 Special_Zone_8920 Anemia, Raynaud’s, psoriasis? Light colored nail beds.
 | I visited a Dermatologist about recurring skin rashes, that seems psoriasis like. One dermatologist mentioned Psoriasis caused by yeast allergy. Another dermatologist mentioned possible DLE, the last dermatologist said it’s some sort of connective tissue disorder and to visit a Rheumatologist, he said he thought that because of my nail beds. I have a negative ANA and RH factor. Elevated CRP, which indicated some inflammation. One blood test I had elevated neutrophils. I have horrible fatigue in the morning. Pain in neck, shoulders and hands- lasts 1-2 hours. Was inconclusive. Those appointments were almost a year ago. submitted by Special_Zone_8920 to Autoimmune [link] [comments] Jump forward to present times, all of those symptoms remain. I have a photo of my nails from last winter, then additionally current photo from today. I’m aware the photo from winter looks horrid I figured it is psoriasis. If you look at most recent photo my nail beds look so white, typically when I’m out in heat exercising. My knuckles also turn very red. Anyone have similar looking nails, with a more definitive diagnosis? In addition, I don’t have defined half moon on my nails regardless of climate. Thank you so much, I will follow with doctor, indeed. |
2024.05.20 02:59 seasonedzb Please Help Me. Doctors tell me I’m all fine.
Hello all, I’m hoping someone can shed some light on what’s going on with me.
Male 29 US
No medications, taking Vitamin D and B12
For the past few months I’ve been experiencing the following symptoms. Random pain in my left armpit/shoulder area right where my arm connects to my torso. Sometimes the pain will shoot down my arm to my fingertips. Recently I’ve developed new more alarming symptoms. I start yawning uncontrollably despite having plenty of sleep. At the same time as I’m yawing, my head will feel very “full” I feel pressure in the back on neck on the left side. The left side of my jaw will hurt. My ears pop. And I feel lost, confused, sometimes even like I’m disconnected i guess? I’ll have trouble understanding when someone is talking to me. It’s almost like I don’t feel present if that makes sense? All these symptoms happen at the exact same time. Meaning it’s either I’m feeling all of them OR I feel completely fine. I’ve even narrowed down when the symptoms start. When I wake up and I’m doing things around the house I feel completely fine, but the second I get into my car the symptoms all hit me like a truck and they don’t stop for the rest of the day. They will continue even when I get to work. The only time the symptoms will stop is if I’m actively engaged in something work related, conversation, or anything stimulating. This has been going on for about 3-4 months.
I don’t know who to turn to anymore, I just want some answers. SOMETHING to bring up to my PCP. Anything. I’ve been to 5 doctors, I’ve gone to the ER twice. Blood tests came back fine except for really low Vitamin D (which I’ve been working on). Had chest x rays and those were fine too. Everyone is telling me I’m fine, I’ve even tried more “non traditional” approaches like Asian teas, and shady chiropractors. Nothing is helping. Doctors are just saying it’s stress it’s stress. I’ve lived with stress my entire life. Why is this happening now? What can it be? What can I do? Somebody please help me because I feel trapped.
submitted by seasonedzb to AskDocs [link] [comments]
Male 29 US
No medications, taking Vitamin D and B12
For the past few months I’ve been experiencing the following symptoms. Random pain in my left armpit/shoulder area right where my arm connects to my torso. Sometimes the pain will shoot down my arm to my fingertips. Recently I’ve developed new more alarming symptoms. I start yawning uncontrollably despite having plenty of sleep. At the same time as I’m yawing, my head will feel very “full” I feel pressure in the back on neck on the left side. The left side of my jaw will hurt. My ears pop. And I feel lost, confused, sometimes even like I’m disconnected i guess? I’ll have trouble understanding when someone is talking to me. It’s almost like I don’t feel present if that makes sense? All these symptoms happen at the exact same time. Meaning it’s either I’m feeling all of them OR I feel completely fine. I’ve even narrowed down when the symptoms start. When I wake up and I’m doing things around the house I feel completely fine, but the second I get into my car the symptoms all hit me like a truck and they don’t stop for the rest of the day. They will continue even when I get to work. The only time the symptoms will stop is if I’m actively engaged in something work related, conversation, or anything stimulating. This has been going on for about 3-4 months.
I don’t know who to turn to anymore, I just want some answers. SOMETHING to bring up to my PCP. Anything. I’ve been to 5 doctors, I’ve gone to the ER twice. Blood tests came back fine except for really low Vitamin D (which I’ve been working on). Had chest x rays and those were fine too. Everyone is telling me I’m fine, I’ve even tried more “non traditional” approaches like Asian teas, and shady chiropractors. Nothing is helping. Doctors are just saying it’s stress it’s stress. I’ve lived with stress my entire life. Why is this happening now? What can it be? What can I do? Somebody please help me because I feel trapped.
2024.05.20 02:48 SpittingTheorems "a large proportion of sublingual tumors are malignant tumors (70–90%)" should i be worried?
I've (29M) been having a list of symptoms, one of which triggered my spidey senses (title is kinda spoiler). The last 4 months I've been dealing with mild pain on my left side of the jaw, a noticeable bump (not hard) under the same side of the jaw noticeable when swallowing, pressure on the neck (worsens at nights), slightly swollen area at the left side base of neck, and dysphagia. My PCP wrote it off as an infection and explained all my symptoms as lymph nodes reacting to the infection, that I'm too young to get worried for anything else. What made me start googling was that last month I felt a hard mass on the the left side of the floor of my mouth (below the tongue) which ultimately ended growing a bit the last couple of weeks.
After googling the anatomy of the mouth, the affected area is the sublingual salivary gland. The mass doesn't hurt but its hard. I kept googling and found the following academic paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749102/
In the introduction its said "Unfortunately, a large proportion of sublingual tumors are malignant tumors (70–90%)" and so now I'm on state of alert. I've read there are other causes for hard masses on the floor of the mouth like salivary stones (Sialolithiasis), Sialadenitis, Parotitis... so my question regarding the statistic is: are conditions like salivary stones (Sialolithiasis), Sialadenitis, Parotitis among the causes of the 10%-30% non-malignant tumors or are tumors a lower % of the overall causes of masses in the sublingual gland?
I ask this because in the introduction of the paper its also said: "Mass of the sublingual gland may be misdiagnosed as the more common diseases on the floor of the mouth, including sialolithiasis as well as inflammatory or chronic sialadenitis" which hints that tumors are a less common cause of masses than these other diseases. Wish I could find a stat for this to ease my mind a bit.
Regardless I'll go to an ENT and insist on having a neck CT scan and do whatever biopsy is needed.
PS: last month I've felt a weird numbness sensation on the left side of my upper lip. Its sporadic (maybe once a day) so I haven't paid to much attention to it but now that I'm here I might as well mention it. Should I bring it up to the ENT?
submitted by SpittingTheorems to AskDocs [link] [comments]
After googling the anatomy of the mouth, the affected area is the sublingual salivary gland. The mass doesn't hurt but its hard. I kept googling and found the following academic paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749102/
In the introduction its said "Unfortunately, a large proportion of sublingual tumors are malignant tumors (70–90%)" and so now I'm on state of alert. I've read there are other causes for hard masses on the floor of the mouth like salivary stones (Sialolithiasis), Sialadenitis, Parotitis... so my question regarding the statistic is: are conditions like salivary stones (Sialolithiasis), Sialadenitis, Parotitis among the causes of the 10%-30% non-malignant tumors or are tumors a lower % of the overall causes of masses in the sublingual gland?
I ask this because in the introduction of the paper its also said: "Mass of the sublingual gland may be misdiagnosed as the more common diseases on the floor of the mouth, including sialolithiasis as well as inflammatory or chronic sialadenitis" which hints that tumors are a less common cause of masses than these other diseases. Wish I could find a stat for this to ease my mind a bit.
Regardless I'll go to an ENT and insist on having a neck CT scan and do whatever biopsy is needed.
PS: last month I've felt a weird numbness sensation on the left side of my upper lip. Its sporadic (maybe once a day) so I haven't paid to much attention to it but now that I'm here I might as well mention it. Should I bring it up to the ENT?
2024.05.20 02:33 Skiesofamethyst How do you come to terms with knowing you are going to eventually lose your baby?
My cat was diagnosed with a pretty aggressive lymphoma just a couple weeks ago (suspected large cell — no symptoms before the tumor and seemed to be mostly localized near the sudden tumor on her neck, slight swelling also in some other lymph nodes but no symptoms in her chest, kidneys, or digestive system, so kind of a weird development of it) and I almost lost her. We are very fortunate that the tumor is responding very well to chemo and obviously there’s no guarantees/ways to predict how things will go exactly, but the statistics aren’t the best for her suspected kind of lymphoma regarding length of remission (if we can get her there).
She’s like a physical part of me, going through this with her has been the worst experience of my life and I’ve never properly lost an animal that I was actively caring for and that I loved so much. I know I’m very fortunate that she’s still here and moderately healthy (I’ve been having a hard time getting her to eat her medication that is mixed in with her food, so that worries me on a daily basis) but I feel so shaken knowing that even if I’m fortunate to get her into remission the odds say the cancer will eventually come back and not be as treatable.
I know obviously that there’s no way that an animal could live as long as us, that this is part of having and loving animals, but I don’t think I’d truly grasped the concept of losing her like this. I’d always just assumed she’d live a long healthy life. And she’s still here and thank god she’s mostly acting the same as normal since starting treatment but it hurts so bad. She’s my ESA and a big part of my sanity/grounding myself in this world with my mental illness. I have no idea how people can do this more than once. I can’t imagine my life without her in it.
submitted by Skiesofamethyst to CatAdvice [link] [comments]
She’s like a physical part of me, going through this with her has been the worst experience of my life and I’ve never properly lost an animal that I was actively caring for and that I loved so much. I know I’m very fortunate that she’s still here and moderately healthy (I’ve been having a hard time getting her to eat her medication that is mixed in with her food, so that worries me on a daily basis) but I feel so shaken knowing that even if I’m fortunate to get her into remission the odds say the cancer will eventually come back and not be as treatable.
I know obviously that there’s no way that an animal could live as long as us, that this is part of having and loving animals, but I don’t think I’d truly grasped the concept of losing her like this. I’d always just assumed she’d live a long healthy life. And she’s still here and thank god she’s mostly acting the same as normal since starting treatment but it hurts so bad. She’s my ESA and a big part of my sanity/grounding myself in this world with my mental illness. I have no idea how people can do this more than once. I can’t imagine my life without her in it.
2024.05.20 02:12 SpaceRuster Chevy Cruze Engine Replacement
My 2017 Chevy Cruze LS seems to have fallen prey to the cracked piston issue (90K+ miles) with all the classic symptoms such as CEL, shaking, piston misfire. An independent mechanic first changed spark plugs and fuel injector, then did a compression test and said I needed a replacement engine. (I don't have cost quotes yet).
1) Should I take the car to the dealer to see if it's possible to replace just the broken cylinder (or all 4) rather than the engine? I gather they can use a borescope to see condition of engine and whether it's possible to salvage it.
2) This seems to be a fairly common issue. I'm out of warranty (60K), but would the dealer or GM be willing to cover part of the cost of cylinder fixing or even engine replacement? [ I've moved, so didn't buy at or use this dealership in the past, so I think the dealer is unlikely to be receptive]
3) I assume the dealer would be more expensive than an independent shop if it came to replacing the engine, right? In any case it would be hard for me to justify spending more than 4-5K for repairs on a car worth no more than 7K.
Thanks for any insights.
submitted by SpaceRuster to cruze [link] [comments]
1) Should I take the car to the dealer to see if it's possible to replace just the broken cylinder (or all 4) rather than the engine? I gather they can use a borescope to see condition of engine and whether it's possible to salvage it.
2) This seems to be a fairly common issue. I'm out of warranty (60K), but would the dealer or GM be willing to cover part of the cost of cylinder fixing or even engine replacement? [ I've moved, so didn't buy at or use this dealership in the past, so I think the dealer is unlikely to be receptive]
3) I assume the dealer would be more expensive than an independent shop if it came to replacing the engine, right? In any case it would be hard for me to justify spending more than 4-5K for repairs on a car worth no more than 7K.
Thanks for any insights.
2024.05.20 01:53 venus87 What else helps with physical anxiety besides beta blockers?
I think my issue is histamine as well as adrenaline and of course anxiety and some depression, ptsd. I have histamine issues as well as a condition called Pots, which I think exacerbate adrenaline… When I am stressed or even a little triggered, or sometimes for what seems no reason, I am getting blotchy in my neck and if Im in like a stressful woke call my whole chest is flushed. I've taken propanoloo and it seems to help but I want to be on more of a daily medicine bc propranolol only works for a few hours and makes me tired. Would a norepinephrine reuptake inhibitor like Effexor work? Or anybody with similar experience and results? The physical signs of adrenaline/anxiety are causing more anxiety blah blah. I'm also considering seeing an endocrinologist and of course therapy but want to have some info in my back pocket.
Thank you
submitted by venus87 to Anxiety [link] [comments]
Thank you
2024.05.20 01:50 Sea-Buy4667 What is the likelidhood of Crohns being missed on a colonoscopy/endoscopy?
Age: 30 Sex: M Height: 171cm Weight:136 lbs Race: other Duration of complaint: 7 months Location (Geographic and on body): Stomach Any existing relevant medical issues (if any): Hashimotos(not on meds), skin condition (likely dermatitis) Current medications (if any): N/A Include a photo if relevant (skin condition for example)I have had a mystery illness over the past year with symptoms of constipation, nausea, reflux, discolored stool, shaking, ramped up nervous system, tinnitus, anhedonia. I also lost 40 lbs of weight (but I did have diet restrictions). Some symptoms would come and go (reflux) but other symptoms like constipation are constantly there. I've become severely depressed and hopeless.
I did an endoscopy/colonoscopy and it didn't show anything other than a polyp that was removed and mild chronic gastritis. GI said it's IBS and told me to go away despite my symptoms continuing.
However, I have learned from the experiences of others that the small bowel isn't properly imaged during endoscopy/colonoscopy and the entire middle part of the small bowel (jejunum) isn't seen. I also did a regular full abdomen contrast CT Scan that didn't show anything. As for blood test, my ferritin is elevated (323) but CRP(1.7) and ESR (2) seems normal. I also did a lactulose breath test that showed I had high methane and hydrogen gas
My doctors don't know what's going on and tend to eventually get rid of me. One of them told me I can't have crohns because I have constipation which is not consistent with the frequent diarrhea pattern that crohns patients have. They also told me that crohns usually shows up on CT scan with thinning of the intestine lining but I've heard some articles say that it's not that accurate for the small bowel.
Is it likely for small bowel crohns to cause more constipation rather than diarrhea when compared to crohns in the colon? Would an MRI be more useful?
2024.05.20 01:27 Kooky_Persimmon_9785 Being neurodivergent is the natural state of the human mind.
The more I think about it the more I believe that being “neurodivergent” is actually the natural response to living in this day and age inside a highly structured society.
And by neurodivergent I mean the characteristics such as sensitivity to bright lights and loud noise, other sensory issues, eye contact, compliance with social norms, symptoms of ADHD like hyperactivity / not sitting still, etc.
For example, for sensory issues, when we lived in nature which we did for hundreds of thousands of years before we started building towns and cities, we would not experience artificial lights and loud noise could indicate danger or unnaturalness. Similarly eye contact could be a sign of threat which is the case in some other mammals and even in some cultures today. Prolonged eye contact and speech might not have been a necessity for a long time until the modern age, where we live in high proximity to each other and language has developed so much that there are a hundred ways to say one thing.
And in the context of work or school, sitting for 8+ hours a day is just not something the human body was made for IMO. We already know inactivity causes many diseases like obesity, heart disease, arthritis, cancer and so on.
All the things related to “social issues” that are associated with neurodivergence is simply the conflict between natural human tendencies and the environment which we live in. I’ve travelled to a lot of countries and found that general human behaviour and societal “rules” varies massively by country or culture and even microcultures like small isolated towns. Which leads me to believe that “neurotypicalness” is not a single set of universal characteristics, rather it depends on the society around you and its specific norms.
I realise that there are varying degrees of neurodivergence and it’s not a black and white separation of neurodivergent vs neurotypical. But basically how neurodivergent you are is how much you diverge from societal norms, rather than how much you diverge from a normal human behaviour (without societal interference). It could be argued that adaptability is a key characteristic of the human brain, however I don’t think this is true beyond adapting to your family or tribe in order to form close connections to ensure survival. It definitely does not extend to a society of 10 million people. Furthermore adaptability in terms of synaptic plasticity work by specific mechanisms of reward and repetition and other things that are not related to social adaptability. So every brain has the ability to be synaptically modified but this is NOT the same as social conformity.
I’m interested to see what others think apologies for the long text
submitted by Kooky_Persimmon_9785 to DeepThoughts [link] [comments]
And by neurodivergent I mean the characteristics such as sensitivity to bright lights and loud noise, other sensory issues, eye contact, compliance with social norms, symptoms of ADHD like hyperactivity / not sitting still, etc.
For example, for sensory issues, when we lived in nature which we did for hundreds of thousands of years before we started building towns and cities, we would not experience artificial lights and loud noise could indicate danger or unnaturalness. Similarly eye contact could be a sign of threat which is the case in some other mammals and even in some cultures today. Prolonged eye contact and speech might not have been a necessity for a long time until the modern age, where we live in high proximity to each other and language has developed so much that there are a hundred ways to say one thing.
And in the context of work or school, sitting for 8+ hours a day is just not something the human body was made for IMO. We already know inactivity causes many diseases like obesity, heart disease, arthritis, cancer and so on.
All the things related to “social issues” that are associated with neurodivergence is simply the conflict between natural human tendencies and the environment which we live in. I’ve travelled to a lot of countries and found that general human behaviour and societal “rules” varies massively by country or culture and even microcultures like small isolated towns. Which leads me to believe that “neurotypicalness” is not a single set of universal characteristics, rather it depends on the society around you and its specific norms.
I realise that there are varying degrees of neurodivergence and it’s not a black and white separation of neurodivergent vs neurotypical. But basically how neurodivergent you are is how much you diverge from societal norms, rather than how much you diverge from a normal human behaviour (without societal interference). It could be argued that adaptability is a key characteristic of the human brain, however I don’t think this is true beyond adapting to your family or tribe in order to form close connections to ensure survival. It definitely does not extend to a society of 10 million people. Furthermore adaptability in terms of synaptic plasticity work by specific mechanisms of reward and repetition and other things that are not related to social adaptability. So every brain has the ability to be synaptically modified but this is NOT the same as social conformity.
I’m interested to see what others think apologies for the long text
2024.05.20 01:14 AmoebaNormal2758 Swollen lymph nodes in groin?
I’ve tested negative for all bacterial STI’s, Syphilis, UTI, & HIV… I haven’t tested for Herpes since I have tested negative for HSV-2 in the past and I OHSV-1 and haven’t had an outbreak in my genitals.
I went to Planned Parenthood since I figured they would know more about Herpes, since a lot of doctors seem to know so little and they said they don’t think it’s Herpes. This was 6 weeks ago.
I’ve had some symptoms that could all be anxiety induced (this has happened before with herpes and other medical conditions). But what I’m starting to worry about is my lymph nodes. For 7 weeks I’ve had swollen, hard, and/or pain in my lymph nodes in my groin. Is it normal to have swollen lymph nodes for almost 2 months with no outbreak?
submitted by AmoebaNormal2758 to Herpes [link] [comments]
I went to Planned Parenthood since I figured they would know more about Herpes, since a lot of doctors seem to know so little and they said they don’t think it’s Herpes. This was 6 weeks ago.
I’ve had some symptoms that could all be anxiety induced (this has happened before with herpes and other medical conditions). But what I’m starting to worry about is my lymph nodes. For 7 weeks I’ve had swollen, hard, and/or pain in my lymph nodes in my groin. Is it normal to have swollen lymph nodes for almost 2 months with no outbreak?
2024.05.20 01:01 qryptidoll Parents w/ EDS?
I'm in the process of seeking a diagnosis of EDS after years of the usual bouncing around doctor to doctor until I got tired of it and started avoiding doctors, ignored my symptoms as much as I could, self medicated, became a mom, and now I've circled back around to trying to figure out whats wrong with my body. As I come up on the almost certainty of me having EDS, I'm thinking more about my daughter.
She had 2 bad falls at school when I wasn't there to see what happened, and I've seen her have a fall where it looked like her knee subluxed. Just kicking a soccer ball, not even while running, which just seems so abnormal. She also frequently talks about pain and I'm stuck between wondering if she's just doing what Mom does (as kids do) or if she's being honest and by not validating her I'll be doing the same thing my parents did, brushing it off, caling it "growing pains", saying "you'll grow out of it". I don't ever want her to feel like I did.
I know kids generally have looser joints, so a lot of the hypermobility tests are considered bunk for them. But is there anything I can do? Should I be looking into pediatric joint supports? Any advice on how to talk to her pediatrician about this without sounding like a hypochondriac? After years of bouncing around drs I just generally expect my concerns to be ignored unless I say it the right way so idk.
Between me almost certainly having it and her bio dad having other related conditions, I'm concerned it's a real possibility for her and I don't want to let her down or leave her feeling broken or unsupported. Part of that is obviously projecting because she's such a happy kid but I don't want her thinking being in pain all the time is normal, I want her to get to be a kid and play sports and do the things she wants to do.
submitted by qryptidoll to eds [link] [comments]
She had 2 bad falls at school when I wasn't there to see what happened, and I've seen her have a fall where it looked like her knee subluxed. Just kicking a soccer ball, not even while running, which just seems so abnormal. She also frequently talks about pain and I'm stuck between wondering if she's just doing what Mom does (as kids do) or if she's being honest and by not validating her I'll be doing the same thing my parents did, brushing it off, caling it "growing pains", saying "you'll grow out of it". I don't ever want her to feel like I did.
I know kids generally have looser joints, so a lot of the hypermobility tests are considered bunk for them. But is there anything I can do? Should I be looking into pediatric joint supports? Any advice on how to talk to her pediatrician about this without sounding like a hypochondriac? After years of bouncing around drs I just generally expect my concerns to be ignored unless I say it the right way so idk.
Between me almost certainly having it and her bio dad having other related conditions, I'm concerned it's a real possibility for her and I don't want to let her down or leave her feeling broken or unsupported. Part of that is obviously projecting because she's such a happy kid but I don't want her thinking being in pain all the time is normal, I want her to get to be a kid and play sports and do the things she wants to do.
2024.05.20 00:48 davegurney2 Anyones anxiety manifests as low blood pressure?
Hi,
Title. Especially when I take pseudoedepherine it can go down to 90/60 and causes tightness on the chest. Which doesn't make any sense because normally this medicine should increase the blood pressure. But while I was under antidepressant last year I didn't have the low blood pressure even when I took the maximum daily dosage of pseudoedepherine.
Anyways I'm 29M, EU, GAD and IBS/reflux sufferer whole my life but last two years symptoms turned into more physical. At least escitalopram and psychotherapy helped with managing many symptoms but I still have these below last two years which never gave me a break if you can relate:
submitted by davegurney2 to Anxiety [link] [comments]
Title. Especially when I take pseudoedepherine it can go down to 90/60 and causes tightness on the chest. Which doesn't make any sense because normally this medicine should increase the blood pressure. But while I was under antidepressant last year I didn't have the low blood pressure even when I took the maximum daily dosage of pseudoedepherine.
Anyways I'm 29M, EU, GAD and IBS/reflux sufferer whole my life but last two years symptoms turned into more physical. At least escitalopram and psychotherapy helped with managing many symptoms but I still have these below last two years which never gave me a break if you can relate:
- Nasal inflammation from inside the nose. No infection or mucus, no polyps, no deviation. Nostrils just becomes enflamed and no air goes through. ENT doctor couldn't find anything, allergy test didn't show anything but I will be seeing an allergist itself on July. My symptoms actually went really bad when I moved into an apartment with underfloor heating two years ago. There is a whole different thread about that if you are curious https://www.reddit.com/Sinusitis/s/ooSgICdkju
- Aching and unstoppable stiffness from under the chin to tip of fingers. Throbbing pulsation and muscle soreness on the neck, rarely on the limbs.
- Increase on IBS and reflux symptoms. I had them since 14 but last 3 years they are crazy most likely since I gained a lot of weight that my BMI was almost 30 but luckily losing weight since last year.
- Not everyday but every couple of days a month burning eyes with teardrops especially laying down in the mornings or evenings.
2024.05.20 00:39 Chen_Geller Season Two and The Great Weta Conundrum
 | Why I don't THINK Weta Workshop Worked on Season TwoAround July 2022, Sir Richard Taylor had this to say about The Lord of the Rings: The Rings of Power: "Our company worked on the first series, we're very proud of the fact that we did." This use of the past tense does seem to imply working only on the first season, but its by no means a definitive reading of the interview. This was shortly BEFORE the show's move to the UK, which we know came to the Kiwi crew by complete surprise, although it remains possible that by that point the showrunners had made the decision, and told Weta that their services will not be required for season two without necessarily going into details.Again, I want to stress that Sir Richard's choice of words by no means guarentees that Weta sat season two out. Then again, we know many of the Kiwi contractors have either stopped working for the show - costumier Kate Hawley and the music ensemble Plan 9, for instance - or radically downscaled their involvement, like caligrapher Daniel Reeve. Where crew from season one stayed on - like John Howe and dialect coach Leith McPherson - they were usually based in Europe or the UK to begin with. Its thus only reasonable to assume Weta will do the same. Weta were good sports to share the lead-up to the Season Two teaser on their Twitter handle, but hadn't commented nor shared the teaser itself, suggesting that they were merely (and characteristically) being gracious to a project they HAD worked on previously, rather than setting-up their own involvement, as they had done in their steadfast embracing of Season One. One of the two major departments Weta worked on for the show in Season One - that being prosthetics - had perforce been put out of their hands for Season Two, with the prosthetics supervisor Barrie Gower replacing Weta's Jamie Wilson. Its unrealistic to expect to ship prosthetics - which have a limited shelf life - from halfway around the world, and ideally you'd want the same studio to be responsible for design, fabrication and on-set application. Although they also worked on Celebrimbor's pressure forge and some of the Numenorean and Elven symbols - including the High-Elven star, practically lifted from their version of Gil-galad's emblem for the New Line films - Weta's other main prerogative was the weapons (but NOT the armour). This included bows, quivers, arrows, shields (including straps) and some props that aren't really used as weapons like Feanor's hammer. The High-Elven Star: essentially a homage Weta's Daniel Falconer snuck into the show While it remains possible that they had kept that department under their belt - at least in terms of concept design rather than fabrication - I find it unlikely. Its true that Weta does provide concept art, without fabrication, for off-shore productions: see their erstwhile work for Denis Villenueve's Dune: Part One as an example. However, the recent teaser shows High-Elven swords and bows that are a notable departure from Weta's High-Elven weapons from Season One. It, of course, remains entirely permissible that the showrunners commissioned new designs from the workshop, and in fact the new, more katana-like Elven swords are closer to Weta's previous iterations of Elven swords (cf. Hadhafang or Thranduil's twin swords) than to their High-Elven weapons for Season One, although they're admittedly not too far off Arondir's sword. Having said that, elsewhere in the trailer we see the same Hawley costumes and armour retained, as well as the same Weta-made weapons from Season One: Arondir is still sporting his daggers, quiver and bow, Pharazon draws his gorgeous, bejewelled sword before the Eagle of Manwe, flanked by guards carrying the same ol' spears. We see Lindon guards with their Battersea-esque shields and spears, Durin III with his ax, Durin IV with his dagger, Adar with his Zweihander, and Isildur still with the confusingly-Rohan-like Numenorean cavalry sword. The similarities would thus make it unlikely to expect for new designs - for the same culture and from the same studio - to be such an aesthetic departure from Season One, especially something as insignificant as a quiver. My educated guess - and that's all it is, a guess - is that its a local workshop emulating the Weta style of old. This emulation can also be seen in other departments, like the new Elven shields - with the same hourglass-like shape as Weta's High-Elven shields for the New Line films, but NOT for the show - and the helmets with the more overt blade-like crests, again in the style of Weta's work for New Line rather than Hawley's more subtle nod to that style in Season One. Not to mention the seemingly greater prevalence of Elves with long manes. Galadriel and company, and their quivers: a design unlikely to be revised from Weta's Season One design (below) unless a new, local Workshop entered the fray. The company's bows, seen elsewhere, are also different to this, more closely resembling Tauriel's bow. https://preview.redd.it/w8da7widcg1d1.png?width=3840&format=png&auto=webp&s=ff7a19e093a8008fbae7a0977a2e52617c18bec9 The OTHER WetaHere it is important to distinguish between Weta Workshop, and WetaFX (nee Weta Digital). Although founded by the same people - Sir Peter Jackson, Sir Richard Taylor and Jamie Selkirk - they're two separate companies: Roughly speaking, Weta Workshop does practical effects, WetaFX does digital effects. While they do some projects - notably Tolkien films - together, its by no means a condition sine qua non that the involvement of the one entails that of the other.In the context of the Tolkien projects, Workshop mostly did weapons, armour and creatures, so not too far off of what they did in the show. Set, props and character designs usually fell to another Jackson company, Six-Foot-Seven, but even then Weta did the bigatures and shared the costume design credit with Ngilla Dickson, Bob Buck and Ann Maskrey (Hawley is credited, too, being that she was the costume designer for the aborted Del Toro Hobbit). WetaFX are working on Season Two, in a capacity at least as big as they did in Season One, where they were the main VFX vendor alongside ILM. Moreso than the Workshop, WetaFX (being one the leading VFX houses in the world), provides services for films and shows all over the world, and frankly a show with the VFX requirements of The Rings of Power couldn't avoid WetaFX if they tried, although "giving them point" so to speak is definitely a meaningful gesture. Strictly speaking, WetaFX is not a design studio: previously in Tolkien pictures, creature design tended to be provided by Weta Workshop, and then rendered by WetaFx. However, sometime before The Rings of Power went into production, one of the Workshop's designers, Nick Keller, became WetaFX' in-house designer, and for Season One had worked on (among other things) Durin's Bane, and so WetaFX' continued involvement in Season Two is meaningful to the look of the show. An (unused) Nick Keller-Weta FX design for Season One: all that remains of it in the show are the spear and the Fell Beast The showrunners entrusted to WetaFX in Season One mostly with places and creatures that had been depicted in the live-action films: Khazad dum as Moria, the view of the Southlands from Ostirith as Mordor, as well as Durin's Bane and the Fell Beasts: its therefore reasonable to assume that the design of Shelob will again be entrusted to WetaFX, although since New Line became stricter with their copyright she's unlikely to resemble the previous depiction of Shelob, no doubt to be excused away by the fact that she's younger. My thoughtSo, where does this leave us? I've long written about the show's audiovisual identity crisis: it would be wrong to assume that, going to New Zealand, the showrunners were compelled to hire Weta and thus fell headlong into a similar aesthetic: rather, there was a concerted effort - the filming in New Zealand and the hiring of Weta being two of its symptoms rather than its causes - to model the show on the live-action films. Nevertheless, dispensing with Weta for Season Two COULD keep this issue at bay.All the same, its clear that if Weta was indeed substituted by another studio, as is likely the case, that studio did their darndest to emulate Weta's style, and in some respects harkened even more heavy-handedly to the style of the New Line films. Perhaps it is a case of, having moved out of New Zealand, wanting to still show they "got it" and overdoing it? The same trend is evident in the digital splicing of Kiwi landscapes into the British countryside, and in the trailer's shameless appropriation of beats (but not lines, presumably with New Line cracking the whip on that end) from the live-action films. All the same, Season Two and on could have been another noteworthy "notch" in Weta's enviable Tolkien belt, which only in this year also entails Tales of the Shire and The War of the Rohirrim. It would have been a good preparation for their forthcoming involvement in The Lord of the Rings: The Hunt for Gollum. I do regret, specifically, that they probably didn't get a crack at the weapons of the Eregion Elves: a new Elven culture they had not touched before, unless some of the designs we see were made for Season One and not shown therein. Beyond that, its useful to keep the same team in place in the interest of season-to-season continuity. Nevertheless, the teaser shows a greater emphasis on such continuity that I had previously believed they would go for. Some early scenes seem to be picking up immediately from the end of Season One, with Galadriel and Elrond - still in the same costumes - catch up to Gil-galad's convoy back on the same Lindon set. Even in other scenes, many of the Numenorean extras seem to be in the same clothes, and while the green Eregion guards got a lot of attention in the teaser, they actually already appeared in season one. A tale of two Narsils, both by Weta but for different companies. As a side-note, it may well be that the Weta designers felt limited by the lega situation surrounding Season One, which required them to recreate different versions of some of their most celebrated props, namely a new, subtly redesigned Narsil. Sir Richard Taylor, in the above interview, said he didn't work on the series because he "didn't feel I had anything new to contribute to the television series." This is curious since he had by then already jumped onboard The Lord of the Rings: The War of the Rohirrim, and in an appearance only shortly thereafter, said of the project that "there's so much that's fresh and exciting." This in spite of the fact that, at first blush, Rohirrim would seem to offer far less by way of new design opportunities than did Rings of Power. In truth, not all of Weta's work on Season One was up to their otherwise-inimitable standards: I'm reminded of a making-of featurette about the making of Orcrist, which required a lot of back and forth between the Weta designers and Sir Peter Jackson. Says designer Paul Tobin: "A lot of our designs were falling into 'I've seen it with Glamdring, I've seen it with Sting." An even more egregious example is for Shadow of Mordor, where a design of an armoured Celebrimbor is almost one-for-one of a design for an armoured Thranduil, a year or two prior by the same artist, although in fairness both designs went unused. I don't want to imply that the showrunners weren't equally forthright in their design process: from listening to John Howe, there was certainly a lot of back-and-forth with his concept art. Even in examing Weta's work its clear that in the case of some of the designs - namely, the Elven Zweihanders, which previously appeared in some Howe concept art - the showrunners came to Weta with their own ideas, rather than just giving them free reign. Nevertheless, it does seem that in a couple of instances, Weta were allowed (perhaps on purpose?) to essentially recycle some old designs: almost all the Dwarven and many of the Silvan and Orc designs are like this. Its cool that Weta got to imagine what Durin's legendary Ax looked like, but they basically took a design for an ax that Dwalin finds in the Erebor armoury and made a subtle variation on it. The Mystics' weapons also betray a similarity, but rather to Weta's work on James Cameron's Avatar! Even less appropriately, a spear designed for the Lindon Elves but not seen in Season One, seems derivative not of previous High-Elven designs, but off of the designs for the Woodland Realm, which would have been the freshest in the memory of the Weta designers. The main difference is the Woodland design abstracts the tree-branch shapes to avoid them seeming, to quote Keller, "too fairytale." Worst still, the Numenorean cutlasses (seen briefly at Elendil's side prior to his promotion) are inappropriately akin to the Laketown swords (again, a design surely fresh on the designers' minds) of all things! Corporate needs you to find the differences between this picture, and this picture...[aside]: They're the same picture. In other cases, the similarities are more abstract and work quite well: both Aranruth and the Elven broadswords - wielded by Galadriel to the Battle of the Southlands and carried by Theo into Season Two but also also brandished by the prologue Elves - feature a similar leaf-like profile to the blade: they would be more-or-less contemporaries of Glamdring, which has a similar shape. Medhor carries (but sadly doesn't get to use) a Silvan version of the Elven Great-sword from the Fellowship prologue. Elsewhere in the film industry, of course, companies like Lucasfilm had turned this kind "reuse, reduce, recycle" mentality into a usual practice, although usually with unused designs, a-la the Shadow of Mordor example: discarded McQuarrie and Cantwell artwork from the 1975 thus ended-up in Star Was projects all the way between 1978 and 2023, where it started feeling increasingly like someone picking through the carcass of a dead movie. In a limited extent, however, it is a useful device in terms of "tapping" into the same, initial sensibility, and as such its been used in Tolkien projects before: The White Council chamber was part of some early Rivendell designs, and similar practices are deployed in Rohirrim and are sure to be used in The Hunt for Gollum. In all these examples, however, it didn't normally involve jumping through the legal hoops that The Rings of Power had to leap through. Neverthelss, there are a great many illustrious designs - from Elendil's Captain sword and Finrod's Dagger, through Feanor's Hammer and Dramborleg (the first Elven hammer and axe in Weta's output) to Aranruth and Medhor's Silvan Great-Sword - all represent wortwhile entries in Weta's oeuvre, and some of the best designs in the whole of the show thus far. Still, it wasn't in vain, being that several such key props are going to stay the distance in the show. |
2024.05.20 00:37 Late-Ad2922 What to put in a planter box here in Tucson?
I have a 10-12’ long planter box at the front of my house that receives several hours of full sun per day. About mid-afternoon, the light is more like part-sun.
This box currently houses a hodgepodge of plants (thanks, former owners!) including Arabian jasmine and pyracantha. Both have done fine in the space, although they have suffered from inconsistent care.
We would like to take everything out and start fresh. What are some plants that you would suggest for these conditions in our neck of the woods? What has worked well for you?
We’ll be installing a drip line for irrigation. One thing we have considered is star jasmine, but we’re trying to keep an open mind. All suggestions appreciated!
(Cross-posted to arizonagardening)
submitted by Late-Ad2922 to Tucson [link] [comments]
This box currently houses a hodgepodge of plants (thanks, former owners!) including Arabian jasmine and pyracantha. Both have done fine in the space, although they have suffered from inconsistent care.
We would like to take everything out and start fresh. What are some plants that you would suggest for these conditions in our neck of the woods? What has worked well for you?
We’ll be installing a drip line for irrigation. One thing we have considered is star jasmine, but we’re trying to keep an open mind. All suggestions appreciated!
(Cross-posted to arizonagardening)
2024.05.20 00:28 permalove [WTS] New Baby Bundle(s) – Two Bundles… AD 20.5s, Custom Gavko, & more!
BUNDLE #2 WITHDRAWN; BUNDLE #1 SOLD;
Baby is home and these knives need gone! This is my final deal on here and I am 100% looking for a yolo or best offer to sell tonight! I appreciate anyone looking, and for all the support I’ve received!
Breaking this out into two bundles, or one big package -- price includes shipping CONUS. Getting it shipped tomorrow if it goes tonight! Accepting PPG&S.
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Bundle #1 – AD 20.5 x 2 + More -- $300 (down from $400)
Bundle #2 – Set of 5 Fixed Blade Knives -- $325 (down from $400)
Both Bundle #1 & #2 -- $550 shipped CONUS;
If both bundles are not sold by 9:00 PM CST, 5/19/2024 – the new effective price will become $500 for both bundles;
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Timestamp and photos here: https://imgur.com/a/xHsY8dh
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Bundle #1 -- $300 (down from $400) -- AD 20.5 x 2 + More Details:
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AD20.5 -- Sheepsfoot Blade in 3V steel -- equipped with limited edition (sold out) Flytanium 'Artifact' multicolored bitrate titanium scales; also sporting a purple Ti stud; with a right-handed Lynch pocket clip in the 'Fade' style, and Flytanium plain titanium backspacer; never carried, perfect condition; centered and flippin' nice.
AD20.5 -- Clip Point Blade in D2 steel -- equipped with limited edition (sold out) Flytanium 'Terra Firma' bitrate titanium scales; carried a few times, but blade shows some dark spots -- very nice condition, centered and flicks nicely;
5x5 Combat Solutions - Prymacy Multi-tool -- great little pry bar that you could use to knock someone out; made of AEB-L steel and 5/32" thick, has a pry-tip, hex driver slot, pocket clip, and bit secured by three o-rings; never carried, might show some light wear;
GITD Resin Bead -- silver / green -- shows silvery & slightly green under normal conditions, when hit with UV light it glows; never used / carried;
Purple titanium bead -- never used / carried;
*Always had those beads pinned for use / equipping with these knives... but, now it's baby time.
Total Spend: $350 (3V+scales) +$130 (D2) +$35+$15+$15 -- $545
*prices for individual items are purchase references, only selling as bundle to fund new baby purchases!
*all items purchased off of the swap some time ago;
*the AD20.5’s also come with original packaging, and original green scales for one knife and black RGT (Ripp's Garage Tech) black scales -- lost other set of original scales;
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Bundle #2 – $325 (down from $400) – Set of 5 Fixed Blade Knives – Details:
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Custom Gavko Fixie $200.00 Excellent condition -- custom made by Gavko -- never used, person before said the same; Nitro V steel w/chisel grind; custom wrapped and custom sheath by Offensive Industries; previous owner said that work cost $100 alone;
PDW x Mummert Ti Knife $150.00 Fully titanium knife with carbidized edge - I never used, person before said they used a few times -- great shape -- comes with kydex sheath & fancy clip!
Spyderco Subway Bowie $130.00 Perrin design with LC200N steel and polymer handle; has a couple of snail trails on the blade, but nothing serious -- very good condition, I never carried -- previous owner stated they lightly carried; comes with kydex sheath, neck chain and box;
Miller Industries SHIV2 Neck Knife $100.00 Basically new, does not come with box -- comes with kydex sheath and super strong bead chain… I swear this thing could be a garrote; rare / discontinued;
CRKT SPEW Fixed Blade w/Custom Sheath $55.00 Comes with custom sheath; lightly used, very good condition; wharncliffe style blade and G10 handle;
Total Spend: $635.00
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***$550 if both bundles purchased together; If both bundles are not sold by 9:00 PM CST, 5/19/2024 – the new effective price will become $475 for both bundles;
*edited for formatting;
submitted by permalove to Knife_Swap [link] [comments]