Label thigh muscle diagram

Reconsidering What Long Covid Could Be Doing To Me

2024.06.01 11:29 cwrace71 Reconsidering What Long Covid Could Be Doing To Me

So...this is likely going to be a long post, I apologize in advance as I kind of just have a lot of my mind to expand upon.
I am a 33 year old male, I first got Covid in late December 2023. It was rough, What complicates this for me is that I didn't feel good before Covid. For years I dealt with major fatigue issues, what some would consider similar to adrenal fatigue type symptoms, low blood sugar feelings every day, anxiety, all kinds of weird stomach/chest sensations, lack of energy, heat sensitivity, anxiety and more. The only things I previously had been confirmed to have that could have contribued to this were low Vitamin D and a hiatal hernia. Over the last few years I've had a batery of heart tests, stomach tests, all never really found much other than the hiatal hernia.
Covid was rough on me for sure. Had the worst cough I've ever had for weeks. Though oxygen remained normal, the worst muscle pains I've ever had, and stomach issues, frequent bowel movement. In the weeks following Covid I felt like my hiatal hernia had been made worse as I was just noticing symptoms in there more. I also feel sleepy way more than I did before Covid. The coughing stopped, but I dont know that any of it totally went away, there were periods of time where I forgot I had Covid and even thought I was totally over it a few times, but right now I am reconsidering it.
The last few weeks I have really been just not been feeling rough..and its nothing new to me totally but it all feels worse.
Muscle pains and soreness...I dont have horrible muscle pains, but I have pains that are just there that I didnt notice before, arms, legs, ribs, back, chest. Now weird feelings werent new to me, but its all so much more noticeable after Covid. Its almost like...My muscles are all just a little heavy/sore, like if I want to go on a walk, its like starting an old car, something at 33 I dont think is the norm, just sitting here typing this paragraph I've noticed a strain/muscle pain in my left knee, upper thigh, fingers, and left wirst. They are low on the pain scale like 2 or 3 out of 10, but they are there. It is similar to the muscle feelings you get when you are sick but not quite on that scale, just a lower level daily 24/7 version of it.
My hiatal hernia has felt so much worse in the last few weeks. I am noticing so much more pressure around it, its almost like a baby kicking in my lower chest/upper stomach when I move positions or lean wrong, or strain. I've had lots of nausea last few weeks also going along with it, it also goes along with the low blood sugar feelings I get which are fixed by foods (not sugar), and sometimes its hard to tell if I am sick or hungry or what.
Along with the theme of stomach issues, and this one gets a little more graphic...I haven't been normal with bowel movements since I had Covid. Atleast my usual. I was..pretty regular pre-covid. Every couple days, maybe once a day, but it was..simple..relatively the same...Since I had Covid, its extremely irregular, much more frequently it can be more diahhrea like, usually very soft, sometimes multiple times a day which used to be extremely rare for me, and where I used to be able to hold it before, it seems to come on much more suddenly for me now.
For a weird one, I feel like my anxiety is worse again since Covid...now I had anxiety for years which was actually caused by all the strange symptoms I had over the years. But it had been maintained and stable before Covid. Now it feels like any adrenaline release at all absolutely screws up my body. Good or bad energy. Watching a sporting event and getting excited = feeling bad...Even gaming...I am an eSports compeititor, mainly with sim racing, but I enjoy other games. I've noticed that if I play a game like Fortnite now, when I get done if its a tense game, I am borderline panic attack and my body freaking out for literally no reason, and it comes on out of nowhere once i'm done. Fortnite seems to do it worst of all games.
There are more things im sure I am forgetting but its very late, and this really hit me today that maybe somehow Long Covid is playing up all of these things after all. I did have an episode of my heart racing last month and they said it was POTS..I had an EKG while it was going, EKG was normal, Chest XRay was normal...I dont necessarily believe it was POTS but I also cant rule it out as I have had other POTS like symptoms before.
submitted by cwrace71 to covidlonghaulers [link] [comments]


2024.06.01 09:30 jazzgrackle The little man by the tall reeds.

I know all of you like to tell your scary stories, I like them too. Way back when my voice was still high-pitched I knew a man who told the scariest stories you'd ever hear, well he wasn't a human exactly, but he sure was a man. A good man by estimation, but you can be the judge of that. See, my mama used to live way down in the rural bits of Texas. Ain't nothing much down there 'sides toads and mosquitos. Fireflies would light up the night sky, and once in a while you'd see a couple eyes comin' up from the water. We lived in a small house, a bedroom, a kitchen, nothing special, but nothing shameful neither. It was just me and mama, papa left a long time ago, mama says he was out on the lake and got eaten by one of them gators. I believed it, he was always drunk and on a tear. He'd go out into the reeds until they got as high as his head. He was big a fella, too. That man'd go out there and throw meat to the alligators, meat my mama said we couldn't afford. And he'd come back scratching from the mosquitos and what else was in those high reeds. He'd stumble into the house and fall asleep somewhere round the door.
None of that may seem wholly pertinent, but it will be, just give it some time. I was outside one evening, mama was asleep. Mama was a hard sleeper, I think she grew up by a train track - Chicago she said, mama was a city girl that came out to the country to raise a big family. It was just me though, I never asked why, but it was always just me. It was a gorgeous evening, the ones you see in those little photo booklets that advertise how beautiful the town is. Fireflies dotted the sky, and a big yellow moon lit the whole way down to the lake. As much as a lake as you could call it, the critters sure did like the water. Bugs, frogs, gators, big and little fish; you could stick a net in the water and be sure something'd be stuck in there.
So, I walked throught the reeds, taking little chunks off the ones nearest me so I could find my way back. It was just a straight walk, but you try walking in a straight line when you're blind. You'll end up going in a circle - I think that's why they say we have a circulatory system. As I'm just near the water, pullin' reeds, and swattin' mosquitos, I see a kid with a lantern, about my height. The lantern was half the size of his body, big flame in the middle of glass, the orange waves danced and flickered lighting everything it touched, and casting shadows where it didn't. The kid beckoned me too him: "Hey, come here" he said. Well, it wasn't a kid, it was a very adult voice. "Little person" I thought, that's what they liked to be called. Just the same I didn't feel too comfortable approaching a man I didn't know.
"Come here, it's all right." And he beckoned again. Something about him, seemed - familiar. I didn't need much convincing, I headed over to him, and he gestured with his hand for me to sit. I sat, and he sat beside me. Wasn't much of a man either, he had a bulbous yellow eyes that searched around and never found anything. Big lips, red splotches just about everywhere. He was fat too, well not quite fat, but somehow, inflated. He was barefoot, and smelled like old hamburgers. I breathed through my mouth, and waited for him to speak again.
"I've got tell you a story about that house you're living in" he said. He paused, just waiting for it to sink in. Somewhere I was livin'. Now, I loved my house, and I loved my mama, but there weren't nothing worth telling a story about there. And everyone in town knew about papa, so it couldn't be that.
"Just me and my mama here" I replied, shifting a bit on the dirt as the small tide lapped close to my sneakers, the shadows from the lantern playing on the water. I had my eyes fixed on the water, always expecting a couple of eyes and a big alligator mouth.
"Just hold on there, I've been around this place a long time, I might know something you don't." He waited again, his eyes whirling, and his hands shuffling around the dirt, like he was lookin' for something on either side.
"Okay, go ahead then."
"There's a woman in that house, sometimes thin, sometimes big. Sleeps heavy, talks about the trains in Chicago"
"That's my mama"
"It is?"
"yes sir"
"She good to you?"
I hesitated. Mama was good, but she was rough sometimes. Sometime she'd get sick, and, well, irrational. She'd yell about how people in the house tryin' to talk to her, wanted to 'get' her. Eventually she'd tire herself out, and then she was a sweet mother then. Cooked the best beef stew you'd ever had, I never had any other beef stews, but her's was real good all the same: "yeah, she's good" I said.
The little man waited again, then continued on: "Well, maybe I'm talkin' about another woman. I couldn't know, your mama seems a wonderful gal."
"Tell me the story" I said. My fingers were tapping on the ground, along the dancing shadows, under that big yellow moon. I could hear the plop of a fish flying out out of the water and right back in. That siren eek of a mosquito came by my air and I shooed it away. And I looked at the water, where it was lit by the flame I could still see the little man. His eyes still whirling, his hands still digging.
"Well, some woman lived in that house. And she had a husband, handsome fellow, maybe a little too hard on the bottle, but he got done what needed to be done. For years the two of them would talk about havin' kids, and it just never happened, well almost never. Don't worry - I'll get to that. Now I want go too into the details because you're so young, but boy did those two try. And sometimes, like woman do when they're ready to become mamas, she'd get nice and big. Then she'd get thin again. Now, her husband was confused to say the very least. His wife'd cry, say the child was taken by the Lord, and they'd continue on about their lives, alone, in that little house by the lake. But funny enough how God works, like a miracle, when they were at their saddest - plenty would come in. See, the woman had a sister from the city who'd send her big packages full of meat and she'd make that meat into a nice stew. Sometimes they even had a little extra, you know what they'd do with it?"
I paused, I knew, I heard the stories. "He'd go throw it to the alligators"
"You're right, he'd throw it right to the alligators, now I don't know if gators can taste spice, but if they can they're mighty tough. That stew was always filled with the habaneros and all sorts of chilis, something you gotta stop and sweat for every few bites. Not those gators though, they'd gobble them right up. I'll tell you though, one day those two did have a child, handsome one too. Fuzzy brown hair, and cute as all get out. Looked' something like you matter of fact. Named him Matthew."
"My name is Matthew" I knew what was going on, I did, and I felt something like fear and something like comfort. Knowing just who this man was saying he was.
"Is it? Well, that can't hardly be a coincidence. I'll tell you something though, Matthew, I lied earlier in the story, I s'pose I should go ahead and tell you the truth."
"What's that?"
"Well, you already figured out, wasn't too hard, that's your mama I'm talkin' about, and yes, I'm your papa. I'm sure you figured that out too. I know I don't look like much not after you know what happened, but I didn't die. I've been living around this here lake since you was born. Your mama says she don't want me back in the house account of how I look. I don't blame her, but it sure is frustrating." there was some rustling in the reeds behind us, and the croak of some old frogs - they always sounded old to me at least.
"And that meat, ain't no packages from Chicago, I don't think Carol ever lived in Chicago, maybe she did, but I never heard from anyone there. And there wasn't so much as a picture to prove it. Those was those little miracles from the Lord. Yes I'd put one in your mama, we'd wait a few months, and we'd have ourselves a nice meal. The first one really was a miscarriage, and we were hungry, so we tried just a bite. Maybe we were both a little too much on the whisky, but we were very hungry. And boy - it tasted good. Best meat I'd ever had. And as long as I could keep fishin' by that lake I could give your mama the energy she needed to make that delicious beef stew."
I got up as fast as I could muster, I tried to run, took a few good strides, and then felt arms on my shoulders, locking me in place, and shoving me down onto the floor. I squirmed and screamed: "Let me go, no!" I cried, and I hollered, but it was no use. It was my mama, she straddled me with her legs, and pinned my arms down so I couldn't move a muscle. She smelled like those old hamburgers. And she smiled the sweet smile she always smiled when she was in one of her better moods.
"We waited a bit longer with you, wanted you to be nice and ripe, and now I think you're ready. Don't you think he's nice and ready, Carol?"
Mama took one hand off me, whipped it behind her back, and pulled out a big kitchen knife. She held it in front of me, and I could say my eyes in the metal, tears were rolling, and my face was red and screaming. Can't say I'd been that scared since.
"Carol, darlin', before we make our meal, how bout' we kiss like we used to. It'd be nice for him to see what a happy family looks like"
"Kiss you?" Mama spat. "You ugly little drunk, not even the alligators would want to kiss your mouth. Last one tried to kiss you spat you right out. I ain't want nothin' to do with that."
"Darling, I missed you."
"I didn't miss you, I ain't lettin' you back in the house neither. You think I can't find another man? Just past this lake I've got a hundred suitors just waitin' to take a gal like me. Bet they have big cocks too, not like your little pecker."
That was enough for papa, He ran right toward mama, I don't know how he did it with those whirlin' eyes, but he did it. He came and pushed mama right off me. I started crawling away as quickly as I could. Papa bit her and mama let out a big yelp: "Fuck!" she screamed; mama didn't cuss much 'less she was real mad. And boy was she real mad. I crawled into the reeds and hid there, lookin' through to see what was gon' happen.
She stabbed him, right in his arm when he tried to block her form his stomach. Big nasty gash, blood running everywhere, a little brown, a little green, but still mostly red. But he kept just goin' kickin' and bitin'. "I'll kill you!" she screamed and slashed, and they both yelped and hollered.
Then, I swear, he started hummin' a little tune, sounded like a nursery rhyme, and the water started to bubble, and I saw two big eyes out of the water, and then that mouth, and a big gator came right up. whappin' his tail, snortin' and groanin' in that way gators do. Bit mama on the leg, and started draggin' back to the water, mama screamed, and kicked, but that gator hung on. Bit up on her thigh, boy was she bleeding, strips of meat, and bone cracked and split. That gator dragged mama right down into the water. There was some splashin' and the gators back would come up and then back down into the water, and occasionally I heard a gurgly scream, but before I knew it the whole thing was over.
My papa sat there, I have to say, even then I felt a bit bad for him. "Son come out of those reeds, I promise I ain't gonna eat you no more."
I came and sat by papa and papa started hummin' again. I started to get up, but he put his hand on me. "Don't worry, she ain't gon' hurt you. I just gotta go away for a while."
The alligator came back on to the land and papa sat right down on her back, she crawled into the water until just her back and his upper body were above the water. "I gotta go son, I'm sorry. One day we might see each other again."
I didn't say a word, what was there to say? I met my papa, and he tried to eat me, now he wasn't, and now he was riding an alligator. So, I just nodded, and secretly hoped that maybe I wouldn't see him again.
And then off he went across the lake until I couldn't see him no more, haven't seen him since either. I went back to the house, and I'll tell you, I heard those voices my mama used to hear, too. But they wasn't mad at all, they was saying thank you. I think those are my brothers and sisters, and I think they thought I did something right. I whispered, "Don't thank me, thank papa, he saved us after all." And then, I'll tell you, nobody ever heard those voices again.
submitted by jazzgrackle to nosleep [link] [comments]


2024.06.01 08:40 EkkoThruTime Interalveolar Septum vs Interdental Septum

I just had the following question on a quiz.
“The bony projection that separates one socket from another is called the”
A) [eliminated prima facie]
B) Interalveolar septum
C) Interdental septum
D) [eliminated prima facie]
Note: I don’t remember options A and D verbatim, but they were obviously wrong so it doesn't matter anyway.
Which is the correct answer? I'm pretty sure in this regard they are synonymous. During the lecture, I remember my teacher saying both were valid names for this structure, she did say there was any distinction between them. If option E) was "both B and C" that's a valid question. Or if the question was "[description]" is called the a) Interalveolar septum b) interdental septum c) both a and b d) [4th option]. That's also a valid question. Especially considering the pertinent learning outcome for that chapter was "Describe, locate and identify supporting structures in the oral cavity". Both option accurate identify the given description. Now if there was another learning out come that was something like "know the common names of things" I would say fair enough, both options are correct but one is more common (interdental). But that wasn't a learning outcome and the question didn't specify "most commonly known as". Is this question valid? Should I dispute the valid of the question to my teacher?
If I am right and they are synonymous, I still expect that they wont adjust the question because I'm realizing now that they err on the side of taking verbatim passages out of the textbook without thinking critically if the question is assessing comprehension of general principles and not rote memorization. Look back at my textbook, I know the "correct" answer is going to be be Interdental septum because that's the only term written in our textbook. But in person during lecture and the labelled diagram on her presentation, she said said interalveolar septum is a synonym for it.
submitted by EkkoThruTime to Anatomy [link] [comments]


2024.06.01 07:27 AllstarGaming617 JUST SAY NO TO SEROQUEL FOR “INSOMNIA”. A cautionary tale with theory from an expert in pharmacokinetics at Harvard.

Long read
I had this originally written under a previous post asking about potential health effects of Quetiapine in this sub. I thought it might be a little much to blow up on someone else’s question. So here is my (long ass) experience and current investigation underway with my rheumatologist in Boston who was an adjunct professor and graduate from Harvard with an expertise in pharmacokinetics.
This will be a dumbed down version the best I can explain as layman with a mere masters degree in physical therapy. While I have a strong grasp of the concepts and language, I may get verbiage or premises incorrect but I believe this will read mostly correct. If you’re a medical professional or chemist, feel free to correct me. Im no writer and I’m sure this will be evident by poor grammar and run on sentences but I did try to do a quick proofread. It’s Reddit though, so…whatever lol.
This is a super individualized account to my neurobiology. Much of it will read as though I’m trying to scare off anyone from ever taking this medication. If you get through it, you’ll see that my doctor’s theory mostly shows the opposite, and the safety profile is extremely good. The people at the highest risk of suffering my fate, that is if he is even correct because this is still just a theory(but well backed) are people in the large cohort of patients being prescribed Quetiapine off label for sleeplessness or “insomnia” as a primary diagnoses.(Spoiler: insomnia is not a real diagnosis, it’s a secondary symptom and why the manufacturer warns physicians against prescribing for sleep).
Seroquel destroyed my life. Prescribed by a “Noctor”(mid level nurse playing with shit she doesn’t know thinking she’s as smart as a doctor) an insane dose of 300mg a night for simple nighttime induced anxiety that messed with my sleep.
This was after suffering an issue where I was on the road and didn’t sleep at all for 4 days. I was really struggling and my employer paid for me to see one of the top psychiatrists on the planet that works specifically with people in my industry(entertainment). We happened to be coming up for a stop in Nashville(where she practiced) and they setup the appointment. I had 6 hours with her where she walked me through the fallacy of insomnia as a primary diagnosis, and that I needed to find the physical or psychological root cause. 90%+ of “insomnia” is just a secondary symptom of mild anxiety with a nighttime onset. That is what she diagnosed me with. Simple anxiety that was triggered at night because my career was so mentally vigorous and non stop that all anxiety was building up with no where to be expressed other than the only time my mind wasn’t occupied by work…laying in bed.
She sent my diagnosis back to my primary in New England and wrote me a script for 8mg of Xanax a month with instructions that I had 2x1mg doses per week to utilize as an emergency med but the goal would be through therapy and self moderation of work to utilize the medication as little as possible.
When I got home from my work trip the only appointment I could get was with the Noctor as my primary physician was booked out for almost 2 months. She looked at the diagnosis from a world class psychiatrist and inserted her own biases about Xanax use under any circumstance being extremely dangerous. Even as an emergency or rescue medication taken a couple times a month. So she choose to nuke my fucking brain with a high daily dose powerful antipsychotic for some night time anxiety.
For a year it was fine other than a little weight gain. Wasn’t too bad for me though because I worked 16+ hours a day on the road 9 months a year.
Then the nightmares started. Like insane, traumatic, horrifically vivid nightmares that would make Stephen king blush. I’ve seen every person and pet I’ve ever know or loved, including myself murdered gruesomely in the most gorey ways in realistic acts of violence, accidents, as well as supernatural monstrous hell fuel.
I’d wake up soaked, covered in sweat and my back and neck would be sore from my entire body being contorted and stiff in terrible positions whilst waking up completely hypertensive due to the vivid hellscape I just awoke from that was indistinguishable from reality.
I went back to her and begged her to change it because I was no longer feeling like I was sleeping. I was just going from one world to another and waking up feeling like I was just in a car accident. She told me it was the only thing she prescribes for sleep because everything else is addicting and dangerous. So I tried to tough it out but after a few more weeks couldn’t take it anymore. I got another appointment and told her I was done whether she liked it or not. I wasn’t getting any rest and I’d wake up in pain like I was hit by truck. She then essentially threatened me. She told me the only way to get off it was to see the psychiatrist at my practice and told me if I went anywhere else she would flag me as a drug seeker. The first date available with that psychiatrist…6 months. So I set an appointment as early as possible with my actual physician(nearly 2 month wait) and figured I’d start weening myself off and by the time I saw my doctor I would be fully off or mostly off.
About 2 days later(I hadn’t even reduced my first dose yet so I was still on 300mg) I was hospitalized. I woke up from my normal nighttime alternate universe of horror completely immobile from my armpits up. I wasn’t numb, but I woke up with my head kinked under my right arm and bent almost completely around. Any movement felt like my spine from my upper thoracic all the way through my cervical spine was going to snap. My wife had to call an ambulance because it was not loosening up like it normally would. While the paramedics tried to board me from my bed I went into shock from the pain and went unconscious.
I woke up in the hospital a few hours later where I learned the doctors had to pump some drug into me that essentially made all of my muscles go completely limp in order to move me out of the position because my muscles were so rigid they couldn’t untwist me. The ER doc said he had never seen anything like it outside of some extreme situations of rigor mortis when someone was found dead in an awkward position and the body locked into that position.
Even once released from that position I felt like I had a knife in my neck. The ER called into my primary physician to update them and they moved my appointment up. In the days that followed my neck only got worse. I couldn’t stand, sit or lay in the same position. I obviously stopped Seroquel immediately. I spent all day flat on my back crying with my wife encasing me in and changing ice packs every 15 minutes. I was ready to kill my self the pain was so bad.
When I saw my doctor a couple days later we were going over my records and I emphasized this was a direct result of the Seroquel that I begged to come off several times because of the side effects and I had learned that even the drug manufacturer didn’t approve of it being used off-label for sleep. She was shocked I was being prescribed 300mg for sleep. I asked her that if she was shocked, why would she approve it considering she was the supervising physician for the noctor that prescribed it to me? She showed me the offices internal notes and the noctor has diagnosed me with mania and disassociation.
Like, WTF!?
There was no record in the practices notes of the diagnoses and recommendations from the psychiatrist I saw in Nashville other than “patient saw a “pill doctor” out of state”, “says he has “anxiety”.
Reading through her notes it essentially accused me of psychosis and drug seeking because I saw a doctor out of state that prescribed me a medication she didn’t agree with.
On my doctor’s end in her oversight of her nurses prescribing she just saw that she was prescribing a patient Seroquel for manic episodes, which is a standard course of action. She agreed that this was a horrible misjudgment, viewed the physical copies of the notes I brought home from Nashville, and immediately changed me to that physicians plan of Xanax as an emergency/rescue med vs 300mg of Seroquel daily.
It was too late though. The pain in my neck never went away. I couldn’t move, I was completely bed bound. The pain in my neck felt like I was wide awake whilst someone dissected my cervical spine with a rusty box opener. They sent me to “interventional pain management” where they then did more non-fda approved “healthcare” by repetitively injecting corticosteroids into my spine.
It only got worse and worse. The pain began to spread from my cervical spine, down into my thoracic spine. I started losing feeling in my arm. Then it was neurological medications like gabapentinoids, muscle relaxers, high dose NSAIDs, tricyclic antidepressants, physical therapy, cognitive behavioral therapy etc…within 8 months that noctor was no longer employed at the office(I don’t officially know if it was from her destroying my life).
After about a year there was still no answers. I lost my job that I had busted my ass for over a decade climbing the industry ladder after getting and advanced degree, and was on the verge of losing my house because I was still completely bed bound 90% of the day.
My doctor out of desperation and lack of answers starts me on narcotic pain management. I had never once touched opioids outside of anesthesia inpatient surgeries related to sports injuries growing up. I was staunchly against the use of opioids outside of that setting. Other than some moderate cannabis use after college(when I was no longer being drug tested for the first time in 6 years) I was pretty brain washed by the drug war zealots. Now I’m a pariah. Both doctors and people in my social circles keep me at an arms length because people drank the koolaid and believe anyone taking an opioid must be a raging addict sucking dick for heroin.
I’ve managed to claw back and slow down the total collapse of my entire life because my pain is now controlled to about 60ish% by pain meds while I go doctor to doctor trying to figure this out. By working as a part time consultant in my industry I’m making just enough money to stop complete asset loss but I’m still eating into my retirement and investments. If it wasn’t for the fact that my wife makes a decent salary we’d already be homeless. Even then we’re hemorrhaging money and are likely going to have to sell our house. At 32 I was on track to retire by 50 and travel the world. Now at 37 I don’t know if I’ll be alive by this time at next year as the inflammation and connective tissue deterioration runs rampant.
Doctors absolutely hate and refuse to try and pin serious medical conditions on bad medical professionals or bad medication. I’ve been through every major “world famous” hospital system here in Boston and they’re willing to look for the answer everywhere accept where I’m telling them it started. Until a few months ago.
I hired a high profile private patient advocate. A woman who is a former internal medicine expert that was the lead in a department at Brigham with a PhD/MD from Harvard and her law degree from Cornell. She found me an expert here in Boston that is a rheumatologist who investigates pharmacokinetics. He produced several redacted papers by the patent holders on Seroquel that show them shutting down the research by a hired lab that found Tumor Necrosis Factor spikes in high doses of Seroquel administered to mice with normal neurological function. 3 other labs confirmed the research and wanted the medication held for retrial in humans.
TNF when not properly regulated by the immune system causes a cytokine storm attacking healthy tissue without the presence of disease/damaged tissue. This is the foundation of most autoimmune diseases.
Seroquel regulates various neurotransmission and endogenous processes in the brain when they are not at their normal levels. Even then the science isn’t perfect on it so often an SSRI is prescribed along side because SSRIs are better understood and it’s kind of a protection from the unknown actions of the Quetiapine(Seroquel).
If those neurotransmitters are functioning correctly and neurological function is fine, introducing something like Seroquel in high doses at constant intervals can be incredibly dangerous.
This is where the black box warnings and requests for bans from the manufacturer of seroquel about off label prescribing come from. They only reported redacted and halted research on TNF production increase associated with the drug because they only ever confirmed the research with mice.
This rheumatologist has essentially shown to me with pretty indisputable evidence that I’ve likely developed a severe medication induced autoimmune disease that is rapidly destroying the connective tissue in my spine and is now jumping to organs. It falls outside the diagnosis of any single autoimmune disease and can only really be classified as MAS(multiple autoimmune disease). Because the research papers are all heavily redacted and were never entered into peer review for final patenting and fda approval there is no case or action for me to bring.
Furthermore seroquel has a pretty high safety record because it’s statistically more normal to have an imbalance of the neurotransmitters that it regulates which means it’s rare to cause the reaction the research found with the mice. Most people have some form, even if mild, imbalance that most often goes without symptoms. But the manufacturers did know the consequences of introducing a high dosage of the compound to a perfectly balanced brain.
I fell into a perfect storm. My neurotransmission was such that a small dose of Seroquel daily likely wouldn’t have hurt me but it was as close to equilibrium that flooding it with a drug that regulates neurotransmission that I exhibited the same outcome as those mice forcing my immune system to drive up TNF production. There is a well known list of medications that can cause autoimmune diseases and the way the drug was patented and approved it escaped this labeling given the uncommon instances of the phenomenon.
I am now in the phase of trialing every biologic/TNF inhibitor known to man to try and get it under control before it completely disables me, or jumps to a vital organ and kills me.
This is still only a theory by an extremely educated expert in the field as autoimmune diseases and tumor necrosis factors are only recently in the last couple of decades becoming more understood. We got a more substantial confirmation that he is correct over the winter when I got my first case of Covid19. I rarely get sick. I am an extremely healthy person that exercises regularly(as much as possible through my pain now) as a former division 1 athlete and eats super clean and balanced. This was the first time since this began to see what my immune system did under duress.
My pain dropped by easily 50%. Meaning my immune system had something to do other than attack and inflame the healthy tissues in my joints and organs. While I felt like shit of course, my neurological pain dropped significantly. Within a week of recovering I had to increase my pain meds back to normal as everything became inflamed again.
The entire point of this rant is this: Seroquel is extremely dangerous…to a small population of people. This isn’t uncommon of most pharmaceuticals. It is a cautionary tale about the off label prescribing of this drug for sleep, and sleep only. DONT ALLOW IT TO HAPPEN TO YOU.
If a psychiatrist, neurologist, or behavioral therapist has well documented diagnostics and evaluation that leads them to believe you have a significant neurological imbalance that leads to a true psychiatric diagnosis you will almost certainly be just fine with Quetiapine.
Unfortunately Seroquel is the most prescribed off-label sleep medication on the market. It needs to be stopped. The primary indication for Seroquel cannot be “insomnia”. The manufacturers tried to hide the pharmacokinetic reasons as to why, but they did black box it and request physicians not to prescribe it for such. Read the insert. Back, neck, and joint pain are all warnings to speak to your doctor immediately and this is why.
submitted by AllstarGaming617 to seroquelmedication [link] [comments]


2024.06.01 06:56 Desperate_Coat_8018 Help- Loose skin making me look so much fatter. Surgery not an option.

I’m 20F and I was at my heaviest two years ago 166cm/90kg.
I lost around 36kg since then and i’m 54kg now. I look disproportionate when I don’t have clothes on because my boobs are deflated, stomach has some loose skin and stretch marks, and thighs and arms also have minor loose skin.
It’s not serious enough for me to get it surgically removed but it’s also enough for me to stress over it.
I honestly feel “fatter” than I felt two years ago for some reason. I don’t know how to explain it, but the loose skin and stretch marks really hurt my self confidence. I’m thinking of getting a boobjob in the future but what the hell am I supposed to do with the excess skin around my body? I’m scared to do strength training because i’m afraid the extra muscle will make me weigh more. I’m also far from my goal weight, so will losing more weight make me look better? Also, is there hope that my skin will regain some elasticity factoring in my age?
submitted by Desperate_Coat_8018 to loseit [link] [comments]


2024.06.01 06:35 doubledgedsword77 What kind of pain is fibromyalgia pain???

I am a 48yo male and suffer from dull aches in back, shoulders, thighs, calfs, biceps, foot soles and glutes. I also have muscle cramps, TMJ pain, jaw stiffness (actually make all body stifness) and muscle/nerve twitches. At this stage no clinical weakness but at times I feel that my dexterity is decreased a lot and can struggle to carry out precise movements. Plus I have constant fatigue. I have seen the primary physician and when I suggested fibro he just started poking different areas on my arm waiting for me to jolt in pain. Now, whilst I do suffer from chronic dull aches, my pain is not so acute that I immediately jolt if somebody touches me. Besides, these aches vary. One day they are more in my thighs, the other day they are in my biceps accompanied by twitches, etc... My doctor's conclusion, therefore, is that I do not have fibro. Is there anyone experiencing similar symptoms or is everybody here super sensitive to touch? Insofar I was told that I have psoriatic arthritis although the previous reuma told me that it was ankylosing spondylitis which turned out not to be true, despite thousands of dollars in testings. So forgive me but I do not trust most doctors, not because I consider them incompetent but because they just can't be bothered... Can anyone list their symptoms or tell me how faclose mine are to fibromyalgia? I don't mean to waste your time but I just need some help to see if I should pursue this diagnosis further. Thank you!
submitted by doubledgedsword77 to Fibromyalgia [link] [comments]


2024.06.01 06:13 Educational_Yam7855 Pushing doctors while being in pain - cancer?

In August 2023 I've (27F) started to have a back pain. In November I've got a swollen lymph nodes on the right side of my neck. I had no infection in that time and it was painless. My doc prescribed me ATB which didn't help a bit. After some time I started to feel dizzy, nauseous, I almost fainted couple of times. I went to ER after a month and a half and they ordered ultrasound. The guy didn't say much and according to blood work there was nothing wrong with me. The problems continued - started to be very tired, pain from the back got to my knees and it's crazy till now. Lymph nodes on the neck got smaller after few months but it remained slightly bigger, also they found more close to my appendix. From time to time they are also in the my thighs. I'm negative for boreliosis, mononucleosis, rheuma and autoimmune deseases. Right now, after 8 months, I have severe burning pain in my back down to my hips and knees. I'm still nauseous and get tired very quickly. I noticed CNS problems, tinnitus, muscle weakness and very weird feeling in my head - I don't have a headache, but let's say my body feels like it changed the way it functions. I had an MR of the brain few months ago, seems fine. I had CT of belly, just the lymph nodes near appendix which are smaller than 6mm. My white cells are somewhat on the edge of normal range but nothing special. My sugar and cholesterol was messing a bit for no reason but it's fine now. I did some basic oncology markers any everything seems to be in a normal range (PIVKA 44; 0-50 range). Yesterday basic blood work CKMB mass 0.5 (twice as more as it should be but according to EKG everything fine.
I feel desperate. I honestly feel something is very wrong and there is no way to make doctors listen. Last one said I should ask for biopsy of the lymph node, which I would like to but I'm scared they're gonna say it's too small. I don't understand how all these scans can come up clear while I'm in such a state. I've been told to go to psychiatrist, to exercise more, wait until it goes away... I'm so tired and it's getting worse very quickly.
I think I'm just venting but if anyone would have any advice on this, go ahead. I was hoping I can get a PET scan by myself but it seems I need a doctor recommendation everywhere.
Just a note: I'm really not a hypochondriac.
submitted by Educational_Yam7855 to AskDocs [link] [comments]


2024.06.01 06:09 ConstructionLevel225 My Eating Disorder

I was 8 when I realize that I was really flat compared to this girl at elementary school who was a bit curvier than me . So I was killing myself at night in my room doing butt exercises shitt that I saw on YouTube and I thought I would be less flat after doing them . At the same time I was forcing myself to eat more (like 4 big meals a day) . Few days later I gave up because I had extreme legs pain . My leg muscles were hurting to bad .
But I didn't gave up the idea that I wanted to gain more weight until school comeback after quarantine where I started being more insecure about my body. I thought I was muscular of my arms and looked like a man so I decide to starve so I could lose muscles to become more feminine but I gave up after 24 hours of starving and ended up binging . I tried this diet called omad so one meal a day but I gave up after like 3 days . So my relationship with food was really weird . I was trying to diet then failling and ending up binging .
And I also remember that this period of my life I discovered about thigh gap . Because I noticed this girl in my school was so skinny that her she had a thigh gap . I thought this was so beautiful so I tired exercises to get them and I didn't finally get them because it's actually due to your pelvis morphology and stuffs and you cannot have it if you don't naturally have it . I have narrow hips so it was impossible for me to have it . So I gave up it . I also remember using a subliminal to get it . But I gave up . So for the last 4 years my relationship with food was about binging trying diets and falling.
Also in 2021 summer I discovered about kpop . I became a fan of BTS and BlackPink and I thought that Lisa (a member of Blackpink) was beautiful because she had a skinny figure and I wanted to absolutely look like her. This period I weigh for the first time and I saw the number 44 kg . I knew it was okay for a 11 years old girl to weigh 44 kg and knew I was fine but I wanted to lose weigh to attain 37 kg (this was my goal weight) .
I know it sounds crazy but it was true . I was watching compilations of skinny Chinese women and I was dreaming looking like them . So I started doing extreme diets like eating only one apple a day and stuffs . But I binged again and again and ended up gaining 5 kg . I attain 49 kg in less than 2 years . Which I am still now . And my BMI is around 20 so I'm fine . I heard about a Tumblr anorexic community . So I decided to join it this new year in January . I tried some diets and failed again until today .
Currently it's midnight 1st June . I always belived that the start of a month is a new start of something new it my life . I still wanna lose weight but I wanna weigh 45 kg or maybe even 40 kg. But not 37. Absolutely not. I'm crazy yes but not to that point. So I know it's super duper unhealthy but I will starve for the whole month of June . What I mean by that is that I won't eat anything but only water and chew gums . That's all I'll consume . No juice no tea no coffe no anything but only water and chew gum . That's all . Even tho there are calories in chew gums 5 calories will not affect my weight . So from today to the end of this month . I'll update everyday about my water fast and how I feel and stuffs about not eating anything for 30 days . I won't push myself until death . I will only stop when I'll feel bad . I don't end up looking like Eugina Cooney but I just wanna look as snatched as Ariana Grande or Wonyoung .
submitted by ConstructionLevel225 to u/ConstructionLevel225 [link] [comments]


2024.06.01 05:53 PyroIsSpai Read this paper -- The Six Levels of UAP Analysis. "Incommensurability, Orthodoxy and the Physics of High Strangeness: A 6-layer Model for Anomalous Phenomena", by Jacques F. Vallee and Eric W. Davis, published in 2003

Links:

  1. https://bdigital.ufp.pt/bitstream/10284/781/1/223-239Cons-Ciencias.pdf
  2. https://web.archive.org/web/20230614115415/https://bdigital.ufp.pt/bitstream/10284/781/1/223-239Cons-Ciencias.pdf
  3. https://www.semanticscholar.org/papeIncommensurability%2C-Orthodoxy-and-the-Physics-of-a-Vallee-Davis/cc83574adbd009c4e36e1f8c5f80b1e884912b00
Original Portuguese:
Resumo
O argumento principal apresentado neste trabalho propõe que o estudo continuado dos fenómenos aéreos não identificados (“UAP-Unidentified Aerial Phenomena”), incluindo “aparições” de natureza religiosa ou espiritual, pode oferecer um teorema para a existência de novos modelos de realidade física. O actual paradigma SETI e a sua “suposição de mediocridade” coloca restrições às formas de inteligência não humanas que podem ser pesquisadas no nosso entorno. Um preconceito semelhante existe nas frequentes declarações dos ufólogos, segundo as quais se os UAP são reais, então devem estar associados a visitantes espaciais. Observando que ambos os modelos enfermam de antropomorfismo, os autores tentam clarificar as questões que se colocam em torno das observações de “alta estranheza”, distinguindo seis níveis de informação que poderiam ser extraídos dos eventos anómalos.
Translated:
Summary
The main argument presented in this work proposes that the continued study of unidentified aerial phenomena (UAP), including “apparitions” of a religious or spiritual nature, can offer a theorem for the existence of new models of physical reality. The current SETI paradigm and its “mediocrity assumption” place restrictions on the forms of non-human intelligence that can be researched in our environment. A similar bias exists in frequent statements by ufologists, who claim that if UAPs are real, then they must be associated with space visitors. Noting that both models suffer from anthropomorphism, the authors attempt to clarify the issues surrounding observations of “high strangeness,” distinguishing six levels of information that could be extracted from anomalous events.

The Six Levels of UAP Analysis

Let us consider the characteristics of the sightings that are not explained by trivial natural causes; we can recognize six major “layers” in terms of our perceptions of these characteristics, as they can be extracted from earlier works about UAP phenomenology (Vallee, 1975a, 1975b) or from the current NIDS database.

Layer I:

First of all is the physical layer, evident in most witness accounts describing an object that:
  • occupies a position in space, consistent with geometry
  • moves as time passes
  • interacts with the environment through thermal effects
  • exhibits light absorption and emission from which power output estimates can be derived
  • produces turbulence
  • when landed, leaves indentations and burns from which mass and energy figures can be derived
  • gives rise to photographic images
  • leaves material residue consistent with Earth chemistry
  • gives rise to electric, magnetic, and gravitational disturbances
Thus UAP, in a basic physical sense, are consistent with a technology centered on a craft that appears to be using a revolutionary propulsion system. It is the existence of this layer that has led mainstream ufologists to claim that UFOs and related phenomena were due to extraterrestrial machines.

Layer II:

For lack of an adequate term we will call the second layer anti-physical. The variables are the same as those in the previous category but they form patterns that conflict with those predicted by modern physics: Objects are described as physical and material but they are also described as:
  • sinking into the ground
  • shrinking in size, growing larger, or changing shape on the spot
  • becoming fuzzy and transparent on the spot
  • dividing into two or more objects, several of them merging into one object at slow speed
  • disappearing at one point and appearing elsewhere instantaneously
  • remaining observable visually while not detected by radar
  • producing missing time or time dilation
  • producing topological inversion or space dilation (object was estimated to be of small exterior size/volume, but witness(s) saw a huge interior many times the exterior size)
  • appearing as balls of colored, intensely bright light under intelligent control
It is the presence of such descriptions that leads most academic scientists to reject the phenomenon as the product of hallucinations or hoaxes.

Layer III:

The third layer has to do with the psychology of the witnesses and the social conditions that surround them. Human observers tend to see UAP while in their normal environment and in normal social groupings. They perceive the objects as non-conventional but they try to explain them away as common occurrences, until faced with the inescapable conclusion that the object is truly unknown.

Layer IV:

Physiological reactions are another significant level of information. The phenomenon is reported to cause effects perceived by humans as:
  • sounds (beeping, buzzing, humming, sharp/piercing whistling, swooshing/air rushing, loud/deafening roaring, sound of a storm, etc.)
  • vibrations
  • burns
  • partial paralysis (inability to move muscles)
  • extreme heat or cold sensation
  • odors (powerful, sweet or strange fragrance, rotten eggs, sulphurous, pungent, musky, etc.)
  • metallic taste
  • pricklings
  • temporary blindness when directly exposed to the objects’ light
  • nausea
  • bloody nose and/or ears; severe headache
  • difficulty in breathing
  • loss of volition
  • severe drowsiness in the days following a close encounter

Layer V:

The fifth category of effects can only be labeled psychic because it involves a class of phenomena commonly found in the literature of parapsychology, such as:
  • impressions of communication without a direct sensory channel
  • poltergeist phenomena: motions and sounds without a specific cause, outside the observed presence of a UAP
  • levitation of the witness or of objects and animals in the vicinity
  • maneuvers of a UAP appearing to anticipate the witness’ thoughts
  • premonitory dreams or visions
  • personality changes promoting unusual abilities in the witness
  • healing

Layer VI:

The sixth and last category could be called cultural. It is concerned with society’s reactions to the reports, the way in which secondary effects (hoaxes, fiction and science-fiction imagery, scientific theories, cover-up or exposure, media censorship or publicity, sensationalism, etc.) become generated, and the attitude of members of a given culture towards the concepts that UAP observations appear to challenge. In the United States the greatest impact of the phenomenon has been on general acceptance of the idea of life in space and a more limited, but potentially very significant, change in the popular concept of non-human intelligence. In earlier cultures, such as medieval Europe or Portugal in the early years of the 20th century, the cultural context of anomalous observations was strongly colored by religious beliefs.
submitted by PyroIsSpai to UFOs [link] [comments]


2024.06.01 05:10 taralynot Help with swelling and compression

So my journey is quite a bit different. I had breast cancer and in February had a dmx and immediate reconstruction with diep surgery. For those who don’t know what that is, a microsurgeon removes skin, fat and blood vessels from your stomach and uses it to reconstruct the breasts. My surgeon did an amazing job. My stomach looks like I had a tummy tuck and I know I had some sort of muscle repair. My new breasts look great with the exception of not having nipples at the moment. I was back to work in 8 weeks.
I just had Phase 2 of this surgery, which consisted of lipo to my flanks and inner thighs and then fat grafting to fill in my new breasts. I was scheduled for the end of June and my surgeon personally called me 2 Fridays ago to come in on that Monday and I took the appointment. Unfortunately, that meant I didn’t have time to tell many people at my job. I worked half day on Monday (had surgery) and then worked from home Tuesday -Thursday and then back to work on Friday. I’m a pediatric OT so my job is physical and I’m always moving. I then worked all week this past week.
I’m looking for some help with compression. I’m under 4 months post op from a dmx, breast rebuild, and essentially a tummy tuck and about 2 weeks post op from Lipo and fat grafting. I am very swollen.
I can’t have any compression whatsoever on my breast area. Lots of compression garments look like they have straps that go over your shoulders and come up right under your breast. I can’t do that. I looked into getting some sort of lipo foam board, but my job is so physical that I don’t think I could use that at work. I need something from my knees to my flanks. Does anyone have something they like? If I used foam board, could it be used intermittently and it still work? What the surgeon gave me goes from slightly under my boobs to my ankles. It’s so hot and uncomfortable. However, they told me to wear it for 2 weeks and then I could switch into something else if I wanted. Monday will make 2 weeks and I need something else!
submitted by taralynot to tummytucksurgery [link] [comments]


2024.06.01 04:44 SammyHasIt 💗🌈My coming out story💕💓

Fuck this is a tough one but here we go. So growing up in my culture men were taught to be men and not showing emotions or feelings and to find a girl of our culture and get married etc. It’s a machismo thing and I fucking hated it because growing up I failed at so many “manly” things. I was very emotional and could never grow body hair or facial hair and was always thin. No muscle, baby face, etc. I was extremely closeted but even then my family knew something was up with me. I’ve always had beef with my older brother too. (Very important for the story)
I also struggle with mental illness. I’m bipolar II, BPD, and high functioning autism. I also struggle with c*tting and my arms/thighs are covered in stories.
Well one day about 5 years ago I went into 5150 for SI and during that time I was hospitalized I was secretly taking HRT behind my family’s back. Well when I was in hospital my A-hole of a brother went into my room, dug around, and found my HRT meds. Sucks because I thought I hid it well. Well he showed it to my family and my sisters are allies and they got super pissed off at him for going thru my stuff and outing me to my family. My parents were incredibly upset and when I came home from the hospital they confronted me. My brother thought I would run back into the closet but I thought about it for a second and without really thinking it through I told them “yes I am transgender and I’m also not straight. I’m bisexual”.
Well my parents flipped out because I was supposed to be a “man” and do manly things. They yelled at me in our language to “cut the bullshit out or else…”. Very forbidding shit. Well I didn’t cut it out. I shaved my legs, finally wore skirts around the house, and just tried my best to be fem and show them this was real.
My older brother told my parents not to worry because this was just a fad and I did it because it was “in” right now. Well little did he know I was dead set on transitioning. I continued on my journey and without notice they hit me with a restraining order. It said I was a threat to my momma. I know my older brother coerced my momma into signing it because he had tried to file one against me on his own behalf but the judge didn’t buy it and saw no threat to him because he’s a big guy. I am petite compared to him. So when that didn’t work he coerced my momma into signing it. He filled it out and she just signed it. I know this because my momma can’t read or write in English.
I was beyond in disbelief but luckily I had a job and a car so when the time came for me to leave I was ready. I wasn’t the best daughter but I was definitely not any threat to my momma. I hugged my momma and we cried. She kept asking me if I had everything I needed and if I needed anything else to let her know now. She tried to give me money but instead I gave her the rent I owed for the month (I regretted that later) and we hugged, cried, and said goodbye. I spent my first homeless night in a Walmart parking lot. I was drinking at the time and I just fell heavy into it. I was drinking all day everyday. Even at work. It greatly negatively affected my life and my health.
A lot of stuff happened but thank god when the time came for my court date it was through Zoom because it was during COVID. We told our stories and the judge could tell where the problem was because he was representing my mommas n her behalf. He set the restraining order at the lowest he could possibly make it for, 3 months. My brother objected and said it should be for years because my momma wasn’t safe. Well the judge called him out on his bullshit and said he could see the real problem was between my brother and I so the 3 months was just a cool down period and that’s why it was the lowest he could set it at.
The judge turned to me and said on the 91st day to call my momma and begin to fix things with her. I said absolutely and I broke down in my car after the hearing (I setup my phone in my car and was sitting in my car during the hearing. I was in a park parking lot). Well I was still an alcoholic, drug addict and homeless. But for the most part I was a functioning addict. Finding a spot wasn’t easy even though I had a job. I can only afford a month to month room and the only one I could find was in a literal trap house deep in the ghetto.
A lot of stuff happened in between finding a spot. I actually had an older guy try to take advantage of me and my situation. He showed me a room and when we were talking about the rent he began to say things like “well I walk around naked sometimes, I hope that isn’t a problem.”. I thought that was weird but whatever, his house his rules. Then he said something along the lines of “I’ll take some rent off if you do some chores around the house”. Said cool sounds good! Then he came out with this bullshit. He essentially said if I do sexual favors for him he’d take a little rent off. I sat there in complete disbelief.
He knew my situation and literally tried to take advantage of it. I said no fucking thank you and got up to leave and he immediately took that back as a joke. But I was so furious I wanted to beat his ass. I don’t wish harm upon anyone unless I can do it with my own 2 fists and I was ready but understood that that would probably ruin my life.
I left and began my search for a room from the start all over again until I found that room at the trap house. After the restraining order was lifted I called my momma and began to fix things with her. I had burned so many bridges because I was an alcoholic and drug addict throughout many years. My entire 20s and most of my teenage years were a complete hazy memory because I was so twisted most of the time. I’ve had many attempts and many hospitalizations. At one point I was in and out of 5150 7 times in a single year.
One day at the trap house I was broke, without a job, down to my last $20 and was suicidal. I called my best friend one night and told her I was ready to off myself. She stayed with me on the phone the entire night. Literally like 12 hours talking.
When the sun rose she told me to call my momma and tell her what’s going on. So I did just that. I called my momma and told her straight up I was an alcoholic and drug addict, had no money, no job and was about to be homeless again. Another thing that happened was my car caught fire one day when I was drinking and driving because I drove with my E brake on so when I parked, smoke came out from the brakes and immediately caught fire. The only thing I could save was my wallet because the fire spread and was engulfed within literally 1 minute. Sat there and watched my car burn. Everything I had was in that car so when the month was over at the trap house I was officially going to be truly homeless. I called my best friend and he came over to wait with me until an ambulance came to take me to 5150. And unannounced to me he went to my mommas house and told her what had happened to my car. She called a tow truck (it was in Walmart parking lot where I slept) and picked it up so I can salvage whatever was left in the car later.
So I called my momma in the morning and told her what was up. I was an alcoholic, drug addict, about to be homeless and without money. (I had lost my job). Told her I wanted to off myself and literally cried and begged my momma that I needed her and to please help me. Told her I didn’t want to die. Literally sobbing like a baby and couldn’t control myself. She also broke down but told me to pack my things and that she was on her way to pick me up to take me to the hospital. She said when I got out we’d try and figure something out. So I packed my things, turned in my key and left (I have pictures of the my room in the trap house to remind myself what I went through. Also have pictures of my burned car)
I told my doc at the psychiatric hospital that I was a drug addict and alcoholic and wanted to either quit or die. He asked me if I was serious or if I was just saying that. I legit begged him to help me. So he kept me in 5150 for 3 months!! For those who don’t know 5150 in California is an involuntary 72 hour psychiatric hold. It’s meant for emergencies and only supposed to be for about a week or 2 to stabilize you and let you go on your way. Well my doc kept tweaking my meds every few days and when he did that he legally had to hold for a few days to see the changes. So every few days he tweaked my meds to hold me longer.
I detoxed in the hospital in a professional setting, took it seriously and began fixing my relationship with my momma. She visited me twice a week, every week I was in there and gave me money for the vending machine each and every single visit. Eventually my daddy came to visit me and I started fixing the bridge I burned with him. I spent thanksgiving, Christmas, new years, and even my own birthday in 5150. After 3 months my doctor told me I was ready to leave so I was discharged into CRP (Crisis Residential Program) for a month to help me with tools to live sober. When I got out of the program I was 4 months sober and I decide to run with it and see how long I can go.
I’m happy to say I’m about 2 1/2 years sober without a single drop of alcohol and drugs. I’ve also began to repair all the bridges I’ve burned along the way. I haven’t been able repair them all but most I have been able to.
I now have the best relationship with my family (minus my only brother) that I have ever had!! I have a decent job, my own apartment, and go to therapy once a week, see a psychiatrist once a month and take my meds everyday. I’m eating healthier and life is just so much better this way!!
I’m still trans and now focus 100% on my transition and it’s been quite the journey. I posted a pic of transtimelines and in the first pic I was about 18 and I was only smiling because I was one on. I was always on one and never smilied in my pictures unless I was on cloud 9.
Not everyone’s journey of coming out is easy and some are more difficult than others. I don’t consider myself a strong willed person or even a good person but I’m trying my best to work and change that. My brother outing me lead to an incredibly dark chapter of my life but ultimately it lead to the best chapter of my life. It was the best thing he could have ever done for me. But I no longer talk to him or have any sort of communication with him and neither do my sisters. He’s a horrible human being that needs help but refuses to but that’s another story. If I could do it then you can too!! I’m not saying destroy your life by coming out if you truly feel you can’t at the moment but there’s always a time and place for everything!!
If anyone needs advice trans related I will be happy to do what I can to help but there’s never a guarantee. I’m the happiest I’ve ever been, I’m living and eating healthy, I’m being my true fem self that I’ve always felt I was! My relationship with my family. My daddy only tolerates me and still gives me crap every once in awhile but it’s better than not having him in my life. We both realized that. But my relationships either my parents and (new) friends have blossomed like never before!! Sorry to rant and for those of you who read it this far. Thank you 🙏🏼
TL,DR: It’s darkest before the dawn.
submitted by SammyHasIt to MtF [link] [comments]


2024.06.01 03:57 Empty_Thought_5307 Nervous About Upcoming Appointment

Hi all, Never posted something before, so bear with me if this is wordy or poorly formatted. I've been having my period for about 8 or 9 years now, and I have been dealing with steadily ramping up pain during and around it. I went to the gyno last summer for irregular periods and had PCOS ruled out, but I was given birth control and told everything hormonally looked fine. Granted, I'd mentioned that the pain ranged from mild to curled up nearly crying, but I did not specify any locations (I forgot, she just asked me about how painful they were and it was my first time at a gyno so I was fairly nervous). I wound up not taking the birth control as I was worried about hormonal BCs side effects, especially on my mood as I already have a history of anxiety. My grandma (who did have endo) thinks it may be what I'm dealing with, and I am starting to think she may be right, but I just wanted to get some outside opinions or reassurance? I have another appointment with my gyno coming up where I wanted to go more in depth about my symptoms, but im pretty nervous about being blown off (my doctor is really sweet, I just constantly convince myself that my symptoms arent actually that big of a deal). My symptoms are as follows:
  1. Irregular periods From the start of my period, it's never been regular and it wasn't rare for me to skip 1-3 months here or there, or settle into a pattern and then one day just completely go out of whack. As I've gotten older, they've only gotten more erractic, and I've had not only cycles where I'm skipping a month, month and a half. But also cycles where I just have really light spotting/light bleeding for a week and a half or so, and then 2-3 weeks later I have a proper full blown period.
  2. Bad cramping My cramps usually only last about the first 3 days or so of my period (situation depending, I'll explain that later) and are worse the first day, but they range anywhere from mild discomfort to barely able to walk or stand long enough to brush my teeth. It has nearly driven me to tears but I've never passed out or came close. Usually it's just in my stomach but recently (within my last few cycles) I've been getting back pain as well. It's usually taken care of with painkillers, although not all work, and even the ones that do work may take a couple doses to kick in, and may wear off a couple hours early, but it does make them bearable and allows me to walk.
  3. Leg pain Starting a few years ago, at random times during some periods while cramping I would rarely get a dull ache in one of my ankles (sometimes left, sometimes right). I usually brushed it off as it went away with painkillers and usually wouldn't come back, and I can't explain how but I just knew it was tied to my cramps. Recently, as of 6 or 7 months ago, I've been experienced an aching pain in my legs, but especially in my thighs and calves in that first 1-3 days of my period. The pain is thankfully taken care of with painkillers, but even with the pain gone I do still have a persistent feeling of general weakness or soreness.
  4. Pain using the bathroom Over the course of my cramping, even with painkillers, I will occasionally struggle to use the bathroom, as it hurts to push the muscles in that area. I get deep cramps any time I tense my abdominal muscles. It's not an issue when I urinate, thankfully, but it does make things more complicated. In addition to this, I will often stick to light foods (ie. soup, salads) during the first few days just because anything heavier feels like it's weighing on my intestines and causes more discomfort. This is a fairly new development, as it only started roughly around the time of the leg pain.
  5. Mystery gas pains This isn't a super big deal, but recently, if im having mild cramping prior to my period, occasionally I will get gas bubbles in the night that team up with my cramps. It's quite painful, it usually wakes me up as it feels like my abdomen is splitting, but resolves fairly quickly upon getting up, going to the bathroom, and massaging my stomach some. It hasn't happening during my actual period, just right before.
This isn't an exhaustive list of what I experience, but it is about 90% of it. Severity ranges from cycle to cycle and so I might not experience all or any of these one month, and then later I might get every single one. Cramps especially, sometimes I will start cramping anywhere from a week and a half before, but they are really minor and come and go. If I do start cramping prior to my period, usually the pain during is very mild, it's when I only start cramping the day of that it gets really bad. I'm not sexually active so I can't say whether I get any pain during sex. My symptoms are limited from anywhere up to 2 weeks before my period, to about 3 or 4 days into it. I don't have any pain or issues at other points in my cycle. Every now and then I will get new symptoms, or the patterns of them may change, but this is just where I'm at right now.
This is really long, and I'm sorry, but if anyone has any personal anecdotes they'd like to share, insights, tips for the appointment, or even just suggestions for pain management, I would gladly welcome it. Shout out to anyone who took the time out of their day to read this, it is much appreciated. <3
submitted by Empty_Thought_5307 to endometriosis [link] [comments]


2024.06.01 03:26 Brilliantmind1997 26 [F4M] Georgia,USA -Seeking a long term monogamous relationship (serious inquiries only)

*Do Not message or add me just to unfriend me or ghost me. * Greetings future partner ❤️ I'm still searching for you. I have to be honest and say that I am losing hope trying to find you.Please be somewhere. I want my search for a partner to be over. I'm seeking adventure in my life with someone I can call a forever partner. I'm tired of the loneliness and the sheltered lifestyle that I've lived. It would mean a lot of you could read through this post so that I could make sure we are compatible. Even if we start off as friends that would be fine.
Here's to new beginnings and new connections. PLEASE make sure you READ through the WHOLE POST also please be respectful when messaging me * *If you're the type to be impatient, block, or ghost easily, then save both of us the trouble and DO NOT message me! I'm not trying to come off as mean but I'd much rather you not message me if you're the type of person to do that. If something isn't working just let me know. We're all adults.
Greetings, I am seeking a long term relationship monogamous with the end goal being matrimony. I am not one for playing around and being used casually as it doesn’t suit me personally. Ideally I'd prefer a man that has his life already in place so that I can be able to share life with him and for him to take care of me. I would expect my future man to have a financially stable job and be able to support me and our future family. I wouldn’t be opposed to being a housewife. There are few reasons why I would like to work or work part time: 1) Being abandoned with nothing, 2) I want to feel fulfilled and not bored. Happy to discuss possible dynamics, I'm flexible. I would love a synergistic partnership where we are both able to mold our minds and fill our hearts with warm affection. I will be there to support you throughout your journey and celebrate every moment with you. I want you to be proud of you just as you are with me. I want to show you that you are truly cared for and appreciated by gestures of love such as massages and other forms of entertainment. I would expect the same from you as well. Even if we are both working adults we can still make our relationship work in the best way possible. I have seen this come out well for people who are dedicated and willing to make their relationships work. For a strong relationship to occur I would expect effective (transparent) communication from you. If you are going to be busy just be honest and let me know you won’t be able to talk to me.Also, if you need your space both mentally and physically let me know. I understand that we all have our lives to attend to but it is incredibly important for people in a relationship to be transparent when circumstances arise in a timely manner in order to avoid future conflict. If this relationship isn’t going to work I would expect you to tell me and not ghost or block me before giving me a reason why. We are all adults so I would expect nothing but maturity. Starting out I don’t want the pressure of sex to be pushed onto me. I’d rather let time tell in all of its glory.
Now onto my true introduction
My name is Angie and I'm from Georgia in the United States. I've been lonely for quite some time and find it hard to find a soulmate in IRL. What I'm looking for is someone who I can connect with and have wholesome conversations with. I want to be able to treat my future soulmate well just as much as they do me. The biggest part of a long lasting relationship is the ability to communicate openly without worry. I'd love it if my significant other has a dark sense of humor and continues to crack me up non-stop. As cheesy as it may sound I long for those late night calls and cute texts. I want for us to drive out the very best in each other; become our support system. A little bit about me is that I grew up in Florida and not too long ago moved to Georgia. I'm currently in college to become an RN but I'm also passionate about cosmetic chemistry and nutrition so I may seek to build my own business in the future. I'm passionate about science and theoretical applications especially within the medical field. I'd appreciate it if my partner is open minded about varying topics and welcomes healthy conversations. Appearance wise I'm open to seeing if we have a connection and feel as long as you are well groomed and practice basic hygiene you are good. Although, I must say that attraction is key in a relationship so I will have to go off on that as well. To add on, I enjoy playing video games, exercising (I've been slacking off lately), cooking and baking (vegan), playing board games, reading, exploring nature, playing sports (basketball and soccer) for fun, and trying new experiences. I hope to save up and travel someday. It would be nice for my partner to be able to set up our travel itinerary.
My Physical Description:
I am a black woman who’s twenty five years old (almost 26 in December) with Afro-Carribean, Japanese and Swedish ancestry. I’d still consider myself black presenting since that’s more along the lines of what I appear as phenotypically. I have dark brown curly hair (Mainly 3c type curls) and brown eyes. I am 5 '4 on the thicker spectrum (not at all obese but thick boned and have thunder thighs). I am trying to exercise more to become fit. I used to weight lift when I was younger but since then have lost lean muscle mass. Having a partner that is willing to work out together sometimes is rather rewarding. A man who has drive and appeal is incredibly sexy. I would also like to point out that I am curvy and noticeable in certain aspects (I’ll leave it up to you to decide).
*You have to be MINIMUM 21 to date me *
If distance will be a problem and you aren't willing to make it work then DON'T MESSAGE ME!!
If you will be too busy to pursue a relationship then DO NOT contact me!! * *Again, No ghosters or blockers!! Seeking a person who seeks a relationship with God and/or is open to one Must be free from venerial diseases and must be willing to get tested(will discuss) Bonus points if you're vegan Ideally I would like someone that is taller than me (I’m 5’4) I prefer a man that is fit or trying to be. I'd prefer someone who is fiscally stable and able to support the both of us* A big red flag for me is smokers. It isn't good for your health nor is it sexy to me.* It's important for me to point out that I want children in the future and need someone who may want that as well. If you're interested in how I look and want to know more about me, message me. Although I don’t make it a huge deal, I do prefer White and East Asian men. But I do love all types of men and welcome them. As stated before I emphasize communication and would prefer you to be honest and say if something is wrong instead of ghosting or blocking without stating the reason. Fair warning if I can be socially awkward sometimes and don't know what to talk about so please be patient with me as I'm learning to be better conversation wise
submitted by Brilliantmind1997 to ForeverAloneDating [link] [comments]


2024.06.01 03:26 Brilliantmind1997 26[F4M] #Atlanta, Georgia - Seeking a long term monogamous relationship (serious inquiries only)

If you're the type to be inpatient then don't bother messaging me! It's a waste of time if you do!
Greetings future partner ❤️ I'm still searching for you. I have to be honest and say that I am losing hope trying to find you.Please be somewhere. I want my search for a partner to be over. I'm seeking adventure in my life with someone I can call a forever partner. I'm tired of the loneliness and the sheltered lifestyle that I've lived. It would mean a lot of you could read through this post so that I could make sure we are compatible. Even if we start off as friends that would be fine.
Here's to new beginnings and new connections. PLEASE make sure you READ through the WHOLE POST also please be respectful when messaging me * *If you're the type to be impatient, block, or ghost easily, then save both of us the trouble and DO NOT message me! I'm not trying to come off as mean but I'd much rather you not message me if you're the type of person to do that. If something isn't working just let me know. We're all adults.
Greetings, I am seeking a long term relationship monogamous with the end goal being matrimony. I am not one for playing around and being used casually as it doesn’t suit me personally. Ideally I'd prefer a man that has his life already in place so that I can be able to share life with him and for him to take care of me. I would expect my future man to have a financially stable job and be able to support me and our future family. I wouldn’t be opposed to being a housewife. There are few reasons why I would like to work or work part time: 1) Being abandoned with nothing, 2) I want to feel fulfilled and not bored. Happy to discuss possible dynamics, I'm flexible. I would love a synergistic partnership where we are both able to mold our minds and fill our hearts with warm affection. I will be there to support you throughout your journey and celebrate every moment with you. I want you to be proud of you just as you are with me. I want to show you that you are truly cared for and appreciated by gestures of love such as massages and other forms of entertainment. I would expect the same from you as well. Even if we are both working adults we can still make our relationship work in the best way possible. I have seen this come out well for people who are dedicated and willing to make their relationships work. For a strong relationship to occur I would expect effective (transparent) communication from you. If you are going to be busy just be honest and let me know you won’t be able to talk to me.Also, if you need your space both mentally and physically let me know. I understand that we all have our lives to attend to but it is incredibly important for people in a relationship to be transparent when circumstances arise in a timely manner in order to avoid future conflict. If this relationship isn’t going to work I would expect you to tell me and not ghost or block me before giving me a reason why. We are all adults so I would expect nothing but maturity. Starting out I don’t want the pressure of sex to be pushed onto me. I’d rather let time tell in all of its glory.
Now onto my true introduction
My name is Angie and I'm from Georgia in the United States. I've been lonely for quite some time and find it hard to find a soulmate in IRL. What I'm looking for is someone who I can connect with and have wholesome conversations with. I want to be able to treat my future soulmate well just as much as they do me. The biggest part of a long lasting relationship is the ability to communicate openly without worry. I'd love it if my significant other has a dark sense of humor and continues to crack me up non-stop. As cheesy as it may sound I long for those late night calls and cute texts. I want for us to drive out the very best in each other; become our support system. A little bit about me is that I grew up in Florida and not too long ago moved to Georgia. I'm currently in college to become an RN but I'm also passionate about cosmetic chemistry and nutrition so I may seek to build my own business in the future. I'm passionate about science and theoretical applications especially within the medical field. I'd appreciate it if my partner is open minded about varying topics and welcomes healthy conversations. Appearance wise I'm open to seeing if we have a connection and feel as long as you are well groomed and practice basic hygiene you are good. Although, I must say that attraction is key in a relationship so I will have to go off on that as well. To add on, I enjoy playing video games, exercising (I've been slacking off lately), cooking and baking (vegan), playing board games, reading, exploring nature, playing sports (basketball and soccer) for fun, and trying new experiences. I love heavy metal and rock music, but also listen to other genres too. I love RPGs, FPS, and simulation games. I hope to save up and travel someday. It would be nice for my partner to be able to set up our travel itinerary.
My Physical Description:
I am a black woman who’s twenty five years old (almost 26 in December) with Afro-Carribean, Japanese and Swedish ancestry. I’d still consider myself black presenting since that’s more along the lines of what I appear as phenotypically. I have dark brown curly hair (Mainly 3c type curls) and brown eyes. I am 5 '4 on the thicker spectrum (not at all obese but thick boned and have thunder thighs). I am trying to exercise more to become fit. I used to weight lift when I was younger but since then have lost lean muscle mass. Having a partner that is willing to work out together sometimes is rather rewarding. A man who has drive and appeal is incredibly sexy. I would also like to point out that I am curvy and noticeable in certain aspects (I’ll leave it up to you to decide).
*You have to be MINIMUM 21 to date me *
If distance is an issue and you aren't willing to commit then DON'T MESSAGE ME!!
If you will be too busy to pursue a relationship then DO NOT contact me!! * *Again, No ghosters or blockers!! Seeking a person who seeks a relationship with God and/or is open to one MUST be free from venerial diseases (must be willing to get tested) Bonus points if you're vegan Ideally I would like someone that is taller than me (I’m 5’4) I prefer a man that is fit or trying to be. I'd prefer someone who is fiscally stable and able to support the both of us* A big red flag for me is smokers. It isn't good for your health nor is it sexy to me.* It's important for me to point out that I want children in the future and need someone who may want that as well. If you're interested in how I look and want to know more about me, message me. Although I don’t make it a huge deal, I do prefer White and East Asian men. But I do love all types of men and welcome them. As stated before I emphasize communication and would prefer you to be honest and say if something is wrong instead of ghosting or blocking without stating the reason. Fair warning if I can be socially awkward sometimes and don't know what to talk about so please be patient with me as I'm learning to be better conversation wise.
submitted by Brilliantmind1997 to r4r [link] [comments]


2024.06.01 03:06 One-Employ7341 Day 10 today

Justfound y'all. I'm on day 10. Still have drainage tubes. Go back to doctor this coming Tuesday.
I thought I would die the first 4 days. Lol. It got a lot better. It wasn't pain from the incisions. It was using muscles to move, go to the bathroom, etc.
I'm feeling much better now. I do want the drainage tubes out so I can take a shower. That will make me feel so much better.
I've got swelling, but it's not awful. I love seeing the tops of my thighs for the first time in years. Haha. They removed 7 pounds of skin. Feels like it was 20 pounds! I look so much better.
I'm 54. Not expecting to wear a bikini. But, just to wear clothes, underwear and bathing suits that fit my body will be AMAZING!!
Hoping everyone is recuperating well and will feel better soon!
submitted by One-Employ7341 to mayTT [link] [comments]


2024.06.01 02:25 speshyy Apple shape body, if I build my glutes will my butt be hard or squishy?

F, 31, GW: 145 CW: 165 Ok hear me out. I have no fat on my butt, and my thighs and calves are very, very lean. You can visibly see my tendons and muscles. However, I have a big belly. My body only holds fat in my upper body. Meaning even when I gain weight, my hips and butt don’t exist. I’m trying to build up my glutes because I have the flattest ass in existence but I’m worried it’s going to continue to be a lean, hard butt. Does anyone have this body shape, built up their glutes from nothing, and have a butt that is still feminine? I can’t help where my body decided to store fat :-/
submitted by speshyy to loseit [link] [comments]


2024.06.01 00:26 critical_courtney [Hot Off The Press] — Chapter Nine

[Hot Off The Press] — Chapter Nine
https://preview.redd.it/bzhyafrd8u3d1.jpg?width=1410&format=pjpg&auto=webp&s=619ea410316f9fc35579da6390cef37812952938
My Discord
Buy me a cup of coffee (if you want)
Previous Chapter
Chapter Ten:
(Dawn)
Heat rose from the frying pan as the cooking oil I dropped in slowly spread around the stickproof steel surface. Outside, I heard Billie call out and then the Fates made a few noisy clucks before going silent.
I tossed a popcorn kernel into the pan and put a glass lid on top, waiting for it to pop. Checking my phone, I saw a text from Frankie Dee. But in my phone, she was listed under “Frankie (Pal, Not Colleague).”
She’d written, “On my way.”
But because lesbians are terminally late for every event they attend, I assumed my pal sent that before even having her shoes on. In fact, the exact order of events was probably: send a text, watch a couple of videos on TikTok, remember the event, mad scramble for shoes and a jacket, and then leave the house.
With a quiet little POP, the dry kernel transformed into its yellow and white counterpart, the movie-watcher’s favorite companion. I tossed it into my mouth, only burning my tongue slightly in the process. Then, I poured several more kernels into the hot, oily pan from a glass jar labeled, “Iowa Organic Popcorn.”
These kernels came from a farm in Iowa owned by a butch lesbian couple. Our school took a field trip to their farm in 9th grade for the usual farm fun, a hay maze (or a maize maze, as I jokingly called it), a petting zoo, and crop science lessons.
All the other kids were fussing over the lambs or screaming and laughing from inside the maze. But I just wanted to learn more about the farmers who’d blown my mind. Women. . . can be together. Like — just be together, in love. That realization felt like something so simple and foundational I should’ve learned years earlier. But, of course, my Bible-thumping father and sheltered church-girl life ensured those kinds of “evils” were excluded from my purview.
Looking back, I’m not sure how he missed that we were visiting a farm run by two dykes. Then again, I guess that wasn’t exactly advertised on the permission slip.
I just remember being glued to the hip of Sadie Henshaw all day long as she showed us tractors, different types of soil, and the feed for their animals. Her blonde hair was cut short and styled like any other man’s hair in Linn County. She was a shorter, stout woman who never went a day without overalls and a ball cap. Her wife, Daniela, handled all of the finances and told us a little about things like farm subsidies and corporate farms vs. mom-and-mom operations.
Some kids left the cornfields that day wanting to be farmers. But I left wanting to be another girl’s wife.
The sound of popping kernels brought me back to the present as I picked up the frying pan and shook it back and forth with the lid on.
A knock at my door revealed a certain newspaper editor had arrived safely. And as I poured the steaming popcorn into a large, blue Finding Nemo bowl, I called out, “It’s unlocked. Come in!”
My mind played a brief scene of Frankie Dee walking into, not just mine, but our house and hanging her keys up on the keyring we’d bought while antiquing. She’d get home after a late night covering a library board meeting or some such, and I’d pull a chicken pot pie from the stove and — fuck. I had to stop this dangerous line of thinking.
She walked into the living room and took her shoes off, just as I was bringing in the giant bowl of popcorn.
“I brought a bottle of wine. I hope that’s okay,” she said.
I smiled.
“That’s perfect. I’ll grab some glasses from the kitchen.”
Frankie watched me scoop a handful of popcorn and place it on The Morrigan’s altar. She raised an eyebrow.
“Does the goddess of war and prophecy enjoy a nice salty sacrifice now and then?”
I snorted and returned from the kitchen with a pair of stemless pink wine glasses.
“First, it’s an offering, not a sacrifice. And second, popcorn has been around since 3600 BCE. You can’t tell me she hasn’t tried it and fallen in love,” I said, plopping down on the couch.
Frankie sat down slower and made sure there was a cushion of space between us.
“Does Artemis not get popcorn?”
I shook my head.
“I only leave animal offerings from things I’ve hunted on her shrine.”
“You hunt?”
Nodding, I motioned toward my bedroom.
“Keep a hunting rifle in the gun safe behind my closet door. I head up to camp a few times a year to hunt small things. Rabbits, turkeys, pheasant, sometimes squirrels if I want to make chili.”
Frankie made an incredible laugh and leaned in closer.
“Squirrels for chili? Are you serious?”
“What’s so funny about that?”
Her smile was bright enough to light up the harbor, and I wanted so badly for her to guide my ship into her port. My heart rate kicked up as she teased me.
Wait a second, I thought. Is she teasing ME? When did we switch places?
“Where on earth did you grow up eating squirrel chili?” she asked, crossing her arms.
I stuffed my face with popcorn before answering.
“Iowa,” I said.
She whistled. Was this the first time I’d heard Frankie Dee do that? Holy shit.
“Corn girl,” she said. “And now you’re here, using our phrases like, ‘up to camp,’ without an issue in the world.”
“I’m sorry. Are people From Away not allowed to use any Mainerisms?” I asked, huffing and eating more popcorn.
Frankie reached over and grabbed a handful.
“It’s cute is all,” she said, closing her arms and throwing back the entire mouthful of popcorn.
I sat there blinking.
“Did you just call me cute?”
“Hard tellin’ not knowin’, bub. What’s my witchy lesson for tonight? Why am I sitting on your sofa?” Frankie asked with a dodge only slightly less artful than Neo’s.
Shaking my head, I rolled my eyes. I’d remember her words and circle back around to them later, long after the wine had been poured.
“Your lesson tonight, FeeDee, is to learn the difference between Hollywood’s idea of witchcraft and the actual use of the craft.”
“So. . . movie night?” she asked.
I nodded.
“Double-feature. We’ll start with The Craft and finish with Hocus Pocus,” I said, grabbing my remote and turning on the TV.
“Shit. We’re going ‘90s tonight. I kind of feel like I should have brought over Capris Sun pouches instead of wine,” Frankie said, pouring me a glass.
“Hey, the night is young. It may not be the ‘90s anymore. But just in case you’re nostalgic, we have technological advances like apps that’ll allow an underpaid delivery contractor to rush into Hennie’s and grab us Capris Suns and maybe even Dunkaroos or Fruit Roll-Ups,” I said, elbowing my guest. My pal. My crush. But most definitely not my colleague or girlfriend.
The movie started, and it seemed like half of the wine in my glass was gone before the opening credits finished. Silence filled the couch as I fought to keep my eyes on the TV and not on the beautiful blonde bombshell next to me.
“Holy shit! Is that ​​Neve Campbell?”
“Yes!” I said. “Just seven short months before two guys forever ruined her life with knives, a cheap voice changer, and a ghost mask. That was a great year for the Scream Queen.”
We sat in silence and watched Nancy, Bonnie, and Rochelle meet Sarah Bailey and introduce her to their witchy ways of worshipping Manon.
“Didn’t they make, like, a billion Scream movies?” Frankie asked, turning our conversation back to a different ‘90s film franchise.
“Yeah, and they’re each amazing in their own way, adding layered commentary of horror movies through the decades. The last couple of movies even had lesbians in them.”
Frankie just smiled and looked back at the TV.
“She was my first crush, you know?” I said.
The newspaper editor turned back to me with a sloppy smile that made me want her lips on mine all the more.
“Who was yours?” I asked.
She snorted but didn’t answer, trying to turn back and watch the movie. But I curled my legs up on the couch and smacked her toes lightly with mine.
“Hey! I asked you a very important question, FeeDee. You can’t just ignore it. Come on. Who was your first celebrity crush?”
Scratching the back of her head, Frankie finished her glass of wine and poured herself another. Meanwhile, I was starting to feel my first glass kick in as a warmth slowly washed over me. For good measure, I poked her toes with my feet again.
“I’m still waiting,” I mumbled.
The look she flashed me was hungry for just a moment, and I felt my body tense. I know I wanted to eat more than just popcorn tonight. But did she?
As her cheeks burned, Frankie Dee blurted out, “It was Cassandra Peterson, okay?”
Neither of us was paying attention to the movie anymore as my smile grew wide enough that I could have turned toward the camera with an excited look on my face, that is if my life was the mockumentary I sometimes imagined it to be.
“Elvira?!” I almost screamed. “Mistress of the Dark?”
Frankie rolled her eyes again.
“There’s no need to get overexcited,” she mumbled, crossing her arms.
I scooted a little closer. Three-quarters of a cushion now separated us.
“You’re right. I guess there’s not. It’s just. . . unlike my first crush, yours actually turned out to be a fellow member of the Sappho Syndicate,” I said, finishing my glass of wine and batting my eyelashes at Frankie.
Why are you acting like this? I thought.
That earned me a belly laugh from my movie date.
“Sappho Syndicate? Is that an actual organization you can join?” she asked in between laughs, doubling over almost in tears.
“Sure is,” I said, feeling more of that wine seep into my brain (because that’s how alcohol works). “We meet on Tuesdays in our matching plaid button-downs and hash out the latest edition of The Gay Agenda. Then, when business is done, we all do laps in the parking lot in our Subarus while blasting Girl in Red.”
Frankie finally stopped laughing and wiped the tears from her eyes.
We went back to watching the movie as I explained to my date exactly what we’d missed, about how the girls each cast a spell to get revenge or improve their lives. And right around the time Nancy’s stepfather died, I realized after she’d stopped laughing so hard, that Frankie had moved closer to me. Only half a cushion separated us now.
Did she do that on purpose? I thought, sipping my second glass of wine. No. It’s only an inch or two. If she really wanted to sit closer, she just would.
Unless. . . she’s playing a game? No. Frankie Dee isn’t the type of woman to play games. I tried to focus on the movie again.
But my mind thought, Which is exactly what would make her suddenly choosing to play a game so surprising!
Shit. We gays really did tend to overthink and analyze everything to death, didn’t we?
Show me a homo, and I’ll show you an inflated sense of anxiety and a catalog of thoughts like “Was that on purpose?” And “What exactly did she mean when she said that?”
The rest of the movie went by uneventfully. I even managed to quiet my brain long enough to enjoy seeing Sarah overcome the coven that turned on her.
“That was actually kind of fun in a B-movie cult classic kind of way,” Frankie said, starting her third glass of wine.
“Yeah. It’s always fun to revisit, even if a movie about empowering women through magic only goes so far when it’s directed and written by men.”
I got up to use the bathroom. When I came back, Frankie was checking her emails.
“Working during movie night?” I asked, raising an eyebrow.
She shrugged.
“I wanted to read Emma’s transcribed interview with a woman running for Cumberland County Sheriff. But I can do that tomorrow.”
“That’s right, you can. Because you have more important things to worry about on date night like the Black Flame Candle being lit and resurrecting three evil witches.”
I waited for the newspaper editor to correct me over calling this “date night,” but she just turned her attention back to the television.
She definitely heard me, I thought. She was looking right at me. Is this also part of her game?
Scanning her face for some kind of smile, I found none and relented, sitting back on the couch as we waited for the film to buffer.
“So. . . Iowa? What brought you to Maine?” Frankie asked in a tone I assumed to be her interview voice. Did all journalists have one of those to fill awkward silences or make easy conversation?
“Fleeing my nutjob church-obsessed father. No offense,” I said, showing my palms and flashing a smile. Truth was, my view of Evangelicals was pretty grim due to my upbringing and the state of this nation over the last several years. But maybe, if I could allow her the space to do so, Frankie might just repair a microscopic piece of my faith in folks who shared her beliefs.
“Ayuh, that’ll do it,” she said and immediately dropped the subject.
Before an awkward silence could grow, the movie started, and our attention was immediately captured by Bette Midler, Sarah Jessica Parker, and Kathy Najimy.
“So. . . they’re like — evil?” Frankie asked, finishing the popcorn.
Before I could answer, I realized something had changed when I’d gotten up to pee. Our thighs were touching!
Holy shit! I thought. There’s no cushion left between us!
Electricity ran up and down my legs, as I racked my brain to figure out what I should do next.
She wants to play? I thought. Fine. Let’s play. I’ll bet she gets flustered and scoots back over. FeeDee’s more of a chicken than all three of the Fates combined.
“Yeah,” I said, slowly stretching and casually draping my legs over Frankie’s. “But they’re really silly. They drain the life from her and turn that dude into a cat. And then they’re resurrected in the modern day. Hijinx ensue.”
Where I expected Frankie to push my legs off her or at least scowl, she instead called my bluff by reaching behind her and pulling down a white fuzzy blanket I kept on the back of my couch.
I just blinked as she spread the blanket over us. Warmth continued to shoot through me, half driven by the wine, half driven by the pretty girl who just blanketed us. Under the blanket, Frankie settled her hand flat against my thigh, and I fought hard to keep from asking, “Who are you, and what have you done with my FeeDee?!”
Except she wasn’t my FeeDee. She was just Frankie. . . my pal, my home-girl, my rotten soldier. She’s my sweet cheese, my good-time gal. Right?
Okay. Maybe she’s leveled up her game, I thought. Gone is the sheepish coworker. Round two.
I had one more move that was sure to tip the scales my way.
I scooted my shoulder closer, leaned into her, nuzzled my cheek against her neck, and left my head resting there.
Game. Set. Match, I thought.
And to my utter consternation, she leaned her head on top of mine, and the smell of her vanilla cashmere lotion was all I could focus on.
Frankie Dee was suddenly a new class of opponent. This would require lots of analysis and overthinking. But fuck me. . . I was just so tired.
I took in another deep breath of Frankie’s lotion and felt my eyelids slowly drop just as Max, Dani, and Allison wandered into the Sanderson cottage.
The last thing I heard before everything went black was Frankie’s snoring. At least — that’s what I assumed the noise was. It was powerful enough that if Paul Bunyan were still around, he’d wonder who was sawing through trees so quickly.
***
Morning light streamed in through my living room windows as the autoplay on whatever streaming service we’d used last night (there are like a billion now) had somehow kept playing and eventually settled on a show about a family of four blue cartoon dogs.
Not long after I woke up, I heard Frankie’s breathing change, and she lifted her head from mine and turned to look at me.
A crick in my neck must have grown through the night because a flashing pain stretched from my shoulder up to my jawline. But I didn’t seem to care as I turned to look into Frankie’s honeyed brown eyes. She said nothing, not entirely awake yet.
My phone told me it was 9:17 a.m.
Before I could think better of it, I said, “At least this time you fell asleep on top of me.”
The newspaper editor groaned and mumbled, “Oh, shut up. I should have been at work hours ago.”
We stood and stretched, and I couldn’t stop smiling while thinking about last night.
“Sorry we missed the rest of the movie,” Frankie said, clicking her tongue behind her teeth.
I shrugged.
“Eh, it’s not as good as The Craft. That’s why I had us watch it last. You want coffee first or a shower?”
The newspaper editor rubbed her face and stretched her eyes wide open.
“Coffee would be divine,” she mumbled before surrendering to my suggestion and stumbling into the kitchen.
I followed behind her with an inescapable smile. Closing my eyes, I muttered, “Blessed be.”
submitted by critical_courtney to redditserials [link] [comments]


2024.05.31 22:35 Academic_Highway_736 Lessons From Customizing Controls

Lessons From Customizing Controls
https://preview.redd.it/k8ftqw8wot3d1.jpg?width=3000&format=pjpg&auto=webp&s=5be97fc4a8222bfd00c88d6cb07c56c93b2c35ae
Many synths and MIDI controllers have assignable faders and knobs. That's awesome because you get to have the most interesting parameters of your synths/patches on your panel . Also you get to use mini synths with big fat knobs, making them portable but also optionally big.
However very soon it's a mess and we need to label the controls. And then we realize we need naming conventions. What has worked best for me is to have 2 classes of labels:
Precise: Exact parameters that I expect to use in almost every synth/patch that I use. Examples
  • Cutoff
  • Resonance
  • LFO Rate
  • A, D, S, R
Descriptive: They give you an idea of what moving them will do, but they are flexible to encompass many different assignments they might have. What they do is context dependent, but they are somehow equivalent enough for you to feel comfortable moving them. This way you use the same layout for various patches or synths, and you are able to develop muscle memory with a single controller, no matter what you are controlling. Inspired by knobs as Wave, Timbre and Shape in the Microfreak, and the parameters in the Model Cycles.
Examples
  • Main: It's the main control, usually for master volume but sometimes for only the level of the most important oscillator, or the frequency of a 2nd filter encompassing all
  • Power: Adds distortion, or levels a sub oscillator, or adds some nasty FM. Anything that makes it WWRRAAAHHH
  • Intensify, Diminish
  • Octave fun: For instance, a fast square LFO in a +/- 12 semitones range. Or adds another oscillator an octave above or below.
  • Spread: Can be Unison detune, or a chorus parameter, or pitch for a second oscillator.
  • Mod: Adds some modulation, either FX or to the wave shape.
  • L1 and L2: Two LFO assignments that sound cool in that patch/synth. For instance, LFO to pitch and LFO to filter. Alternatively, some parameter change respectively to LFO 1 and LFO 2 if what I'm using has 2 LFOs.
  • Gate: A button or pad set as a gate (not toggle), to accentuate only temporarily the performance. For instance maxing out the reverb.
  • Config: A toggle that changes a configuration I might change often and I'm lazy to menu dive. For instance, Free LFO vs BPM Sync LFO
  • Open: Reverb level, or Release level, or some delay.
  • Numbers in pads: CC steps to make abrupt changes. For instance in the S1 each pad is an LFO shape. In the Volca KEys each pad is a Voice Mode.
  • A/B, C/D: Gate changing abruptly between 2 cool states within the synth/patch.
Hope this inspires you and if you've got other tips please share!
submitted by Academic_Highway_736 to synthesizers [link] [comments]


2024.05.31 21:19 Both_Hamster1216 Race in 2 days

I have a race coming up this Sunday. 1,175 miles of training this year. I’m battling an injury though. My right inner thigh muscle wrapping around my butt is tingly. PT says it’s an abductor strain. Other people say Psoas. It sucks to admit this but I’ve been running on it for 2 months and I don’t think it’s fully healed. I’m wondering if I should sell my bib to someone and bow out. I did 2:55 at Carlsbad this year and was hoping to go even faster this time. Idk if I should just rest for a couple days and roll the dice or maybe I’ll just run a little to see if it’s strong enough to hold up. I’ve been doing about 40 miles a week since the injury, down from my usual 80. 29M.
Please share thoughts and stories of similar situations. Maybe I’m just anxious or putting too much pressure on myself to PR.
submitted by Both_Hamster1216 to Marathon_Training [link] [comments]


2024.05.31 20:45 DiscombobulatedCup59 How would I describe the type of BBL I I want ??? Doctor recommendations ?

Hello, So I’m thinking about getting a BBL with Lipo and ab etching . The thing is I don’t want hips I want it to look like a muscle butt . I don’t want the typical BBL look. I already have big thighs and I want to just have a gym look , Im 5’4 /135 pounds . Do you think doctors would understand what I mean ?
submitted by DiscombobulatedCup59 to PlasticSurgery [link] [comments]


2024.05.31 20:36 BilgeYamtar A informative post about LEV / Biotech.

A informative post about LEV / Biotech.
https://dw2blog.com/category/aging/


In that scenario, to give one illustration, adults who are aged 65 in 2050 will generally be healthier than they were at the age of 50 some 15 years earlier. They’ll be mentally sharper, with stronger muscles, a better immune system, cleaner arteries, and so on. That’s instead of them following the downward health spiral which has accompanied human existence throughout all of history so far – a spiral in which each additional year of life from middle age onward brings a decline in vitality and robustness, and an increase in the probability of death.
Members of the extended longevity community express a variety of degrees of optimism or pessimism on such questions. The pessimists highlight what they see as a lack of significant progress over recent decades: not a single person has reached the age of 120 this century. They also lament the apparent unfathomable complexity of the biological metabolism, and differences of opinion over theories of what actually causes aging. They may conclude that the chance of reaching LEV by 2040 is less than one percent.
In contrast to that pessimism, I believe there are strong grounds for optimism. That’s the subject of this essay.
To be clear, there’s no inevitabilism to my optimism. I offer a probability for success, rather than any certainty. Whether humanity makes it to LEV by 2040 still remains to be seen.
THEORIES OF AGING
It’s true that aging is complicated. However, we don’t need to understand all aspects of aging in order to reverse it. Nor do we need to map out a comprehensive diagram of all the relationships of cause and effect at the biochemical level. Nor to pinpoint all the interactions of every gene in every cell of the body. Nor to debate whether aging happens because of evolution or despite evolution. Nor whether aging is best understood from a “reductionist” perspective or a “holistic” perspective.
Instead, to my mind, we already understand enough. There are plenty of details still to be filled in, but we already understand the basic framework that can lead to the comprehensive reversal of aging.
I’m referring to the damage repair approach to ending aging. This approach views aging as the accumulation of damage at the cellular and biomolecular levels throughout our bodies, with that damage in turn reducing the vitality of bodily subsystems. Moreover, this approach maintains that our biological vitality can be restored by repeatedly intervening to remove or repair that damage before it reaches a critical level.
What needs to be researched, therefore, is the set of interventions that can be developed and applied to remove or repair biological damage, without having adverse side-effects on overall metabolism.
These interventions need to be understood at an engineering level rather than at a detailed scientific level. We need to ascertain that such-and-such interventions result in given observable reductions in cellular or biomolecular damage. The way in which damage accumulates before being removed or repaired is of secondary concern.
This approach involves categorizing different types of damage, where each type of damage is associated with one or more potential mechanisms that could repair or remove it. Examples include:
  • A decline in the number or health of stem cells available – which could be addressed by the introduction of new stem cells
  • An accumulation of cells that are in a senescent state – which could be addressed by bolstering the innate biological mechanisms that normally break down these senescent cells
  • Damage to the long-lived proteins in the extra-cellular matrix that normally supports cells, with results such as the stiffening of arteries – which could be addressed by a variety of mechanisms including breaking crosslinks between adjacent proteins.
In this understanding, what needs to be done, to accelerate the advent of LEV, is to:
  • Identify and research mechanisms that have the potential to remove or repair aspects of the damage
  • Determine how these mechanisms might be applied in practice
  • Consider and monitor for potential side-effects of these mechanisms, and, as required, design modifications or alternatives to them
  • Consider and monitor for potential interactions between various such mechanisms.
This program was first suggested over twenty years ago. It was the subject of a major book published in 2007, Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime, and it has been explored in a series of academic conferences held at various times from 2003 onward in Queens’ College Cambridge, San Francisco, Berlin, and Dublin. (Since you ask, the next one in that series is taking place in Dublin from 13-16 June.)
My own optimism that LEV might be achieved by 2040 is based on my assessment of the viability of this damage repair approach. In turn, that’s because I see:
  • A wide set of potential damage repair interventions that deserve further study
  • Early encouraging signs that damage repair can extend healthy lifespans in various species
  • A general pattern that slow progress in a field can transition into a new phase with much faster progress
  • Ways in which “breakthrough initiatives” can trigger such a phase transition for the project to achieve LEV.
I’ll now turn to each of these four points in sequence.
Damage repair mechanisms – plenty to explore
There are five basic sources of ideas for mechanisms to repair or remove damage at the cellular and biomolecular levels throughout the body:
  1. Identifying and improving the repair mechanisms that already work within the human body when we are younger – before these mechanisms lose their effectiveness
  2. Learning from the special self-repairing features of the small proportion of humans who are “superagers” in the sense that they reach the age of 95 without having suffered any of the usual age-related diseases such as heart disease, cancer, dementia, or stroke
  3. Learning from the fascinating self-repairing features of numerous species which avoid various age-related diseases, and which can retain their vitality for decades longer than other species with whom they share many other characteristics
  4. Learning from other regenerative features that various species possess, such as the regrowth of damaged limbs or organs, as well as the birth of a baby whose cells are aged zero from parents who can be many decades older
  5. New interventions that don’t exist anywhere in nature, but which can be introduced as a result of scientific analysis and engineering innovation (relatively simple examples are blood transfusions, and stents that can repair a narrowed or blocked blood vessel; more complicated examples involve nanobots and 3D printing)
Here are some pointers to descriptions of various results obtained so far from investigations of possible damage repair interventions – disappointments as well as successes:
Some conclusions from this data are uncontentious:

  • None of these treatments, so far, have resulted in animals passing the LEV threshold
  • The extension of healthy lifespan achieved in these trials is generally less than 50%, and is usually significantly less than that
  • Results obtained in experiments with shorter-lived animals, such as mice and rats, often do not translate into similar results with humans (or have not done so yet).
These conclusions would appear to bolster the case for pessimism mentioned earlier. However, they are by no means the entire story:
  • The various trials indicate that at least some rejuvenation can be engineered, and that there are multiple ways of doing so
  • Trials of combinations of different rejuvenation treatments (which might be expected to have more substantial results) are still at an early stage
  • Nothing like a proof of impossibility has been found, or even seriously suggested
  • The total amount of resources dedicated to this field is far below that in many other fields of scientific research; the field might, plausibly, be expected to make faster improvements if it gains more support.
Key to faster progress will be the removal of roadblocks. That’s the subject of the remainder of this essay.

The possibility of a phase change

Sometimes a field of technology or other endeavour remains relatively stagnant for decades, apparently making little progress, before bursting forward in a major new spurt of progress. Factors that can cause such a tipping point to such a phase change include:
  • The availability of re-usable tools (such as improved microscopes, molecular assembly techniques, diagnostic tests, or reliable biomarkers of aging)
  • The availability of important new sets of data (such as population-scale genomic analyses)
  • The maturity of complementary technologies (such as a network of electrical recharging stations, to allow the wide adoption of electric vehicles; or a network of wireless towers, to allow the wide adoption of wireless phones)
  • Vindication of particular theoretical ideas (such as the paramount importance of mechanisms of balance, in the earliest powered airplanes; or the germ theory for the transmission of infectious diseases)
  • Results that demonstrate possibilities which previously seemed beyond feasibility (such as the first time someone ran a mile in under four minutes)
  • Fear regarding a new competitive threat (such as the USSR launching Sputnik, which led to wide changes in the application of public funding in the United States)
  • Fear regarding an impending disaster (such as the spread of Covid-19, which accelerated development of vaccines for coronaviruses)
  • The availability of significant financial prizes (such as those provided by the XPrize)
  • A change in the attitude of researchers about the attractiveness of working in the field
  • A change in the public narrative regarding the importance of the field
  • The different groups who are all trying to find solutions to problems in the field finding and committing to a productive new method of collaboration on what turns out to be core issues.
When such factors apply – especially in combination – it can transform the pace of a change in a field from “linear” or “incremental” to “exponential” or “disruptive”, meaning that progress which previously was forecast as requiring (say) 100 years of research might actually happen within (say) 15 years.
That’s a general pattern. Now let’s consider how it can apply to accelerating progress toward LEV.
The existing roadblocks
Based on my observations of the longevity community stretching back nearly twenty years, here are my own assessment of the roadblocks which are presently hindering progress toward LEV:

  1. Lack of funding for some of the experiments that would produce important new data, since commercial interests such as VCs see little prospect of them earning a financial return from supplying that funding.
  2. Some people who are in a position to supply funding to support important experiments choose not to do so, because they are dominated by a mindset (sometimes called “longevity myths” or the “pro-aging trance”) that it’s wrong to support significantly longer lifespans.
  3. More broadly: society as a whole assigns insufficient priority to the comprehensive prevention and reversal of age-related diseases.
  4. Some potential supporters are deterred by what they perceive as irresponsible or untrustworthy aspects of the longevity field (snake-oil solutions, uncritical claims, tedious infighting).
  5. There is disagreement or confusion about which experiments are most important; as a result, available funds are being misdirected into, for example, less useful “lifestyle research”.
  6. Related: there is no agreed list of which experiments (or other research) should be conducted next, once additional funds become available.
  7. In the absence of biometrics that are accepted as being good measurements of overall biological aging (as opposed to measuring only an aspect of biological aging), it’s hard to know whether treatments increase the life expectancy of any long-lived animal.
  8. It’s likely that pools of data already in existence contain important insights related to aging and its possible alleviation – namely biological and other health data about individuals as they age and pass through different experiences and treatments. However, much of this data is kept in proprietary or private databases and isn’t made available for scrutiny by other researchers. Especially with the greater power nowadays of data analysis tools such as deep learning, the potential for open analysis isn’t being achieved. (This is another example where commercial or personal concerns are preventing the development of public goods from which everyone would benefit.)
Given this analysis, let’s look at four initiatives that could coalesce to cause the kind of phase transition discussed above.

The breakthrough initiatives

From one perspective, the breakthrough initiatives involve biomedical reengineering: projects such as the RMR (Robust Mouse Rejuvenation) study of combination interventions, designed and managed by the LEV Foundation. These are projects which have the potential to make the whole world wake up and pay attention.
But from another perspective, what most needs to change is the availability and application of sufficient funding to allow many such biomedical engineering projects to proceed in parallel. This can be termed the rejuvenation financial reengineering initiative – the initiative to direct more of the world’s vast financial resources toward these projects.
Taking one step further back, the financial reengineering will be facilitated by perhaps the most important initiative of all – namely narrative reengineering, altering the kinds of stories people in society tell themselves about the desirability of the comprehensive prevention and reversal of age-related diseases. Whereas today many people have an underlying insight that aging and death are deeply regrettable, they manage to persuade themselves (and each other) that there’s nothing that can be done about these trends, so that the appropriate response is to “accept what cannot be changed”. That is, they lack “the courage to change what can be changed”, in turn (to complete the citation of the so-called “serenity prayer” of Reinhold Niebuhr) because they lack the wisdom (or awareness) that such change is possible.
In parallel, important elements of community reengineering are required:
  • To clarify which experiments and research have the biggest potential for dramatic results
  • To avoid behaviours or statements which alienate or deter important potential supporters
  • To reduce amounts of wasteful duplication and “noise”
  • To develop and publicise meaningful quantitative metrics of progress toward LEV
  • To share more openly both the successes and the failures of experiments conducted, to allow more effective collaborative learning.

The breakthrough narratives

Some observers are pessimistic about any changes any time soon in the public narrative about the desirability of reaching LEV. These observers say they have been awaiting such a change for years or even decades, without it happening.
Part of the answer is that experimental results will make people pay attention. When middle-aged mice have their remaining life expectancy doubled – and then when similar treatments become available for middle-aged pet dogs – it is going to cause a large number of “road to Damascus” conversion experiences. People will set aside their former proclaimed “acceptance” of aging and death, and will instead start to clamor for rejuvenation treatments to be made available for humans too, as soon as possible.
But another part of the answer is to develop new themes within the public conversation related to aging and death. If these new themes have sufficient innate interest, they may develop a momentum of their own.
Here are some of the potential “breakthrough narratives” that I have in mind:
  1. Building on top of the latest “longevity dividend” and “evergreen society” arguments in the new book by the economist Andrew Scott, The Longevity Imperative: How to Build a Healthier and More Productive Society to Support Our Longer Lives, to highlight the broader economic and social benefits of biorejuvenation treatments
  2. The fascinating learning that can be obtained from looking more closely at the damage repair mechanisms already utilized by some “superaging” animal species; more and more of these mechanisms are being discovered and explored, and deserve greater publicity.
  3. Additional learning that can be obtained from further study into human superagers. Note that, for evolutionary reasons, it is likely that different superaging families around the world employ different biological damage repair mechanisms.
  4. The RMR narrative that the particularly useful data to collect is that from the combination of multiple treatments administered in mid-life; as this data accumulates, it is likely to give rise to lots of new theories about interactions between these treatments.
  5. The attractiveness of extending the RMR projects (for the robust rejuvenation of middle-aged mice) to similar investigations that might be called RDR (focused on dogs) and RSR (focused on simians, that is, monkeys and apes).
  6. The ups and downs of the various teams that are entering the XPrize Healthspan – a contest that can be seen as promoting an “RHR” extension (the ‘H’ for “human) to the RMR / RDR / RSR progression mentioned above
  7. A new analysis to supersede the existing “hallmarks of aging” diagrams, with a richer model of the interactions between different types of aging damage and the different possible damage repair mechanisms.
  8. Exploration of some “left field” rejuvenation interventions, such as those of Jean Hébert about growing and using replacement organs (including gradual replacement of parts of our brains), and those of Michael Levin about the ways in which the electrome can trigger biorejuvenation.
  9. The new possibilities that are continuing to emerge that take advantage of CRISPR-style genetic reprogramming and the reprogramming of epigenetics by Yamanaka factors or other means.
  10. More powerful AI platforms can enable faster advances in fields of science than were previously expected; examples include AlphaFold by DeepMind and the so-called menagerie of AI models utilised by Insilico Medicine
  11. Further championing of the ideas of anti-death philosopher Ingemar Patrick Linden from his book The Case Against Death.
  12. Engaging new video versions of some of the above narratives, in the manner of the CGP Grey video of Nick Bostrom’s allegory “Fable of the Dragon Tyrant” and those in the “Aging” YouTube playlist of Andrew Steele.

A probability, not a certainty

As I said earlier, there’s nothing inevitable about the longevity community experiencing the kind of tipping point and phase transition that I have described above.
Instead, I estimate the probability of humanity reaching LEV by 2040 to be less than 50%, although more than 25%. That’s because there are plenty of things that can go wrong along the way:
  • Distractions and loss of focus
  • Too much infighting and lack of constructive collaboration
  • A decline in the understanding and use of scientific methods
  • The field becomes dominated by pseudoscience, uncritical hero-worship, snake-oil, or wishful thinking
  • A growth of societal irrationality and preference for conspiracy thinking
  • An adverse change in the global political and geopolitical environment
  • The triggering of one or more of what I have called “Landmines”.
Which set of forces will prevail – the ones highlighted by the optimists, or those highlighted by the pessimists?
Frankly, it’s still too early to tell. But each of us can and should help to influence the outcome, by finding the roles where we can make the biggest positive impact.
submitted by BilgeYamtar to singularity [link] [comments]


2024.05.31 20:36 FNGamerMama Is new cat(kitten) in pain? Back leg injury

Hello!
So was visiting husbands rural hometown and a young cat (approx 7-8 months maybe) showed up (this happens a lot there) and was meowing constantly and trying to come inside, following us around, just all around being so friendly. He was limping on his back left leg and he had a idk 4 inch approx spot that was healed and hair was growing back on but you could tell he was hurt there in some way (I was thinking maybe large abscess previously?) that spot is located on his body kinda around the hip/flank/thigh area. If you feel both sides of his legs, his left back leg has significant musculoskeletal differences it feels like a whole muscle is missing on his thigh. The local vet thought that he might have been hit by a car and didn’t think he was in pain or that we needed to xray but his limping gets worse sometimes and he seems to struggle a little or show hesitancy to jump. He’s also a rather vocal cat and it is sometimes hard to tell if he’s vocalizing for pain or not. We haven’t done an xray yet (we were on vacation, we’re not anticipating taking a cat in and didn’t have a ton of money after our trip) but we’re wondering what yall though if he was in pain in an injury like this or after healing if he’s probably fine. The vet said it’s healed by now and just what it is. And if it was painful what would people typically do?
submitted by FNGamerMama to AskVet [link] [comments]


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