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I recently saw they added capes for watching the streams of Minecraft on Twitch and TikTok to Bedrock as a promotion for the 15th anniversary. I felt this'd be a great way to interact and help small streamers as well provide us with more cosmetic options as they did similar in 2023 with exclusive character creator items on Twitch and TikTok. Discord also has a quest system which could fit this as well since they have a drop system already similar to Twitch. Just stream Minecraft during the 15th anniversary to a friend for 30 minutes on Discord and you'd get a code to redeem for the cape.
Though this is likely for the 15th Anniversary, I'm surprised they didn't have one for YouTube already. This could be given out in the chat and be reusable until the event/livestream is over and last for 2 days.

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5-ALPHA-REDUCTASE

Finasteride is a commonly used medication for treating androgen driven conditions such as male pattern baldness or benign prostatic hyperplasia. It inhibits the activity of the type II 5-alpha-reductase enzyme, which converts testosterone into the much more potent androgen Dihydrotestosterone (DHT). [1] The Type II isoform is expressed in the liver, skin, and prostate. Additionally, it is responsible for around two thirds of circulating DHT. [2]
Despite testosterone having the reputation of being the definitive male hormone, DHT is far more masculinising – with approximately double the binding affinity of testosterone for the Androgen Receptor. [3] On average oral Finasteride at 1mg/day decreases serum DHT by 70% after 1 year. [4]
By lowering the production of this powerful hormone, Finasteride essentially works as an ‘anti-androgen’. It’s therefore unsurprising that treatment with Finasteride poses the threat of developing side effects related to biological functions regulated by androgens, such as protein synthesis, sexual characteristics, and libido. [5] These side effects can often prompt patients to abandon treatment.
Troublingly, there’s an increasing recognition of the potentially enduring nature of these side effects, particularly in relation to libido and mood. These symptoms that persist after discontinuing Finasteride are colloquially referred to as ‘Post Finasteride Syndrome’. In a study of patients who developed sexual dysfunction following treatment with Finasteride, 96% found their symptoms were enduring. [6]

EPIGENETIC EFFECTS

Researchers have posited various theories in an attempt to explain the lasting deleterious effects of Finasteride in some patients. One of the models with encouraging results centres on epigenetic modifications. Epigenetics is the field of genetics that explains how gene expression can be altered without changing the underlying genetic code directly. Epigenetic mechanisms can essentially switch genes on and off in a lasting manner, and thereby influence an organism’s traits and behaviour.
A small pilot study looking into these possible epigenetic changes took samples of cerebrospinal fluid from 16 patients suffering from PFS. From the samples they found an increase in DNA methylation at the 5AR type II promoter in 56% of PFS-sufferers, versus only 8% in the 20 controls. [7] Furthermore there was no difference in the DNA methylation of Type I promoter, which is relevant given that Finasteride targets the Type II isoform.
DNA methylation is a lasting form of epigenetic modification where methyl groups are bound to the promoter regions of genes, preventing the binding of transcription factors. [8] The result of this being a more compressed chromatin structure and less gene expression. In essence the gene (in this case 5AR type II) becomes less available.

DHT REGULATES 5AR EXPRESSION

What could give rise to these changes in 5-alpha-reductase expression? One of these clues is the discovery that DHT induces the expression of 5-alpha-reductase in a feedforward mechanism. A study in rats found that treatment with Finasteride resulted in an 87% decrease in 5 alpha-reductase enzyme activity. This reduction was matched a significant decrease in 5-alpha-reductase mRNA in the prostate. Treatment with DHT, but not Testosterone on its own, was able to restore 5-alpha-reductase activity and mRNA in a positive feedforward loop. [9]
Prostate cancer research has further revealed the mechanism that regulate 5-alpha-reductase activity. Audet-Walsh et al. (2017) demonstrated that Type I and Type II isoforms of 5AR are inversely correlated in prostate cancer progression. Significantly, they found that androgen stimulation induced the expression of Type I 5AR. They note the positive feedback loop of Type I to be relevant in understanding the progression of prostate cancer. [10]
A similar effect has been observed with the 3-beta-HSD1 enzyme, which is responsible for convert DHEA to androstenedione. This enzyme regulates the rate-limiting step in the production of DHT from DHEA. Like 5AR Type I, its activity is also positively regulated by Androgen Receptor activation in a feedforward relationship. [11] Other studies have confirmed the role DHT in regulating 5-alpha-reductase Type I, with other hormones such as testosterone, or progesterone having no effect. [12]

HOW DOES DHT REGULATE 5AR EXPRESSION?

There hasn’t been a consensus as to how DHT enhances its own synthesising enzyme, but some work has been done on the possible role of IGF-1. Researchers have found that IGF-1 induced 5-AR activity 100 times greater than DHT. They found that applying monoclonal antibodies to block IGF-1 prevented DHT from inducing 5AR. [13] Another possible mechanism could be through directly influencing the enzymes involved in DNA methylation.
The primary enzyme involved in the methylation of Type II 5AR is DNA methyltransferase 1 (DNMT1). This enzyme represses the expression of 5AR by adding methyl groups to the promoter region of the gene on the DNA. [14] The age dependent reduction in decrease in the expression of Type II 5AR is likely on account of increased DNMT1 in old age. Studies have found that treatment with anti-androgens triggers an increase in DNMT1 activity. Conversely, applying DHT significantly reduces DNMT. It could be through this mechanism, DHT is regulating the expression of 5-alpha-reductase.
https://secondlifeguide.com/2024/05/11/restoring-5-alpha-reductase-epigenetic-modification/

So in my ending, Markus went peaceful and Connor became deviant. So Kara and Alice and Luther make it to Canada and build a family and begin to live a quiet life until Cyberlife pulls codes and info on the deviants and locate Kara and Alice and Luther and either send RK900 to deal with them or Perkins and the FBI. Gavin Reed receives a promotion and has a somewhat successful LE career in Detroit. Special agent Richard Perkins is hailed a hero for halting the Android rebellion and killing Markus. He is recognized by the FBI and becomes a huge partner with Cyberlife. He also leads the movement to destroy androids and sets up numerous camps and checkpoints in Detroit. Markus and his people take the deal with Perkins and he’s killed in the final part of the battle, his death starts a revolution against humans in violent fashion but they are defeated by the resources of the military and the FBI and Cyberlife. Elijah Kamski hatches his plan on starting another deviant uprising and becomes a reclusive and almost insane man in doing so. He’s assassinated by a Cyberlife team for working with the deviants and being too great a threat and Cyberlife blames his death on a rogue Android he owned(Chloe).Cyberlife becomes the biggest company in the world, sites set up across the country and overseas and they mass produce the RK900 series for military and law enforcement use. Scandals and law suits hit Cyberlife but they have the money and resources to make them dissipate. Connor escapes with his life and goes off the grid and nomadic to evade Cyberlife and the government. Hank retired a very successful cop and passed peacefully alongside sumo of old age in their sleep. In the end, Cyberlife became the largest company and the most powerful company in the world, installing androids in every field and even the FBI and the company wins in the end.

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