5'1, 22 AFAB. Not diagnosed officialy with IBS but clearly show symptoms of it (in terms of bloating, food intolerance, and occasional diarrhea). Diagnosed adhd, undiagnosed-suspected autism, ARFID (not officially diagnosed but has been tracked on my records since I was a child). Taking dexedrine for adhd, iron for anemia, vitamin d, and lion's mane, and occasionally hydroxyzine for anxiety. edit: I'm also on depo-provera for BC, not having active sex. Haven't had any side effects from it either
Since about 22021 I've had on and off rectal bleeding which would mostly be in small spurs of blood, usually from my anus than on the stool. My doctor checked my underside to see if I had any hemorrhoids or anal fissures and she didn't notice anything. She prescribed me a cream and let me know that if it persisted that she could get me an appointment with a gastrointestinal doctor. Months passed, I've moved to a different state, and the past day and a half has had LOTS more bleeding. What I would say is much more concerning. I don't really have any pain like how I used to in previous years (feeling like glass when you pass stool), and now I'm just seeing lots of fresh red blood both coming out me and on my stool. I'm fairly concerned because I shouldn't be bleeding this much and I'm at least not aware of any other symptoms I'm having. I need to see a doctor for what I suspect is De Quervain's tenosynovitis in my left hand, so I'm wondering if it's worth waiting or seeing a doctor immediately. I know I'd probably need some tests done to see what could be the issue and I'm nervous for what could be going on.

40(f). Medical conditions: chronic migraine (treated with ajovy, cambia and zomig), depression, panic disorder (treated with escitalopram), ADHD (treated with low dose of dexedrine) and insomnia (treated with low dose of zopiclone as needed), pernicious anemia (treated with b12 injections) and iron deficiency anemia (treated with iron pills). Height 5'6, weight 145lbs.
Hi everyone, I am currently 12 days late. I have been tracking my cycle for years and am generally extremely regular; at most I may run three or four days late or early once a year or so, so 12 days late is extreme.
I had unprotected sex with my partner 31 days ago, he did not finish, but intercourse is intercourse so initially thought I could be pregnant. I took two tests when I was six days and the nine. Both came up as negative.
Since the tests were negative, the only thing I can think of is that stress could be the cause (I work in education and my role is incredibly stressful) however I have been on a medical leave due to migraines since mid November.
At what point does this become something I should contact my doctor about? I know that false positives can happen, but 2 when I was already about 8 days late? Other than extreme fatigue (I am dealing with chronic migraines which drain my energy and cause depression), I don't have any symptoms of pregnancy.
Could this be perimenopause? Is this how it happens in such an extreme way? I have never ever been late like this before in my life, so I am feeling extremely confused about what is happening to my body.
Any insight or suggestions would be appreciated. Should I just wait this out? Should I contact my doctor? Should I do another pregnancy test?
Thanks for reading.

I just need support or suggestions or something.
I was really unknowingly depressed and anxious before starting on my ADHD meds. Just constantly fatigued, always dehydrated, emotional numbness, no sense of pleasure or motivation or maturity as a 19 year old. Nothing felt like it mattered.
I started on Dexedrine and my life changed completely. I actually felt like I could make friends and do adult things like look for a job. I finally felt interested in my hobbies again and I didn’t feel lonely all the time. Even my fatigue went away and my general body weakness and pain went away. I ate well because I stopped binge eating, I thought I was hot and I actually felt REAL human emotions for the first time.
But as I grew tolerant of my ADHD meds, I got really scared and started going to clinics a lot hoping that it was medical. I wanted there to be a word like anemia or hypothyroidism so it could be treated, and had a cure. But I seemed to be fine. My hair was falling out, I was in so much neck and back pain, and I got terrible GERD. I was started on antidepressant after antidepressant but my immune system was wonky so either they made me more depressed or I ended up being allergic to them. With my stress, I also got a multitude of different allergies like milk and eggs and gluten and I felt like my body was breaking down on me.
That’s kinda where I’m at. I’m on Effexor with my ADHD meds that have basically stopped working, and I genuinely feel like giving up. I’ve powered through so long of this. I have no friends, have finally started coming to terms with the abuse by my mom and my dad is working through cancer. I’ve lost a lot of my drive to feel the same way I did when my ADHD meds worked and I’m close to ending it all.
I’m so tired. I oversleep everyday, my eyes are progressively getting worse and worse, I feel like I’m in a walking dream constantly, I’m trying to go on bike rides to at least bring my mood up a bit but it isn’t working. I tried to make friends but I ended up getting so anxious that I threw up and no matter how many times I try, I can’t form bonds with others. I eat well, I am hygienic, I try SO hard, but my depression lost me my friends because I was too much for a lot of them, and I don’t have the strength to reach out to the rest.
The only thing that has ever worked are my ADHD meds, but they actively are making me feel worse and worse. I was in this state but not as bad before Dexedrine. I’ve even tried Wellbutrin. The doctors are actively getting fed up with how hard I am to treat. There literally isn’t any point to keep fighting, I have no one to keep going for. I wanna love someone so bad.

They’re kinda cool
I’m 19M, 5’1, 97 pounds, I don’t drink or smoke or do any recreational drugs. I’m on Dexedrine for my ADHD and have been for 6 months. I just started Effexor 2 days ago, and have been incredibly nauseous and anxious so far. I take .25u testosterone injections every week, and I’m type 1 diabetic.
I’ve had other weird things come up. Intense brain fog, headaches, a stiff neck, back pain, tunnel and blurred vision, general weakness and fatigue, muscle twitches, white fingernails, hair loss, blurred vision, extremely low moods, random onset of multiple allergies, etc. My doctor keeps insisting that I’m ok. I’ve done tests for anemia, hypo and hyperthyroidism, B12 deficiency, they checked my liver a month ago, I don’t have ketones, they’ve checked my heart in the past 2 months and I’m ok, they did an X-ray of my chest and neck and I’m ok, but I still feel this way. Anyone know what might be going on?
eye video:

I got here at 1 AM, it’s like, 6:30 AM. I’m going nuts.
I have very very severe ADHD, and am figuring out I may also have a mood disorder like BPD or Bipolar Disorder (both very different but I have symptoms of both so I’m working with my psychologist to track my mood).
I was basically numb before ADHD medications. I was depressed and insecure and unaware of it, extremely unhealthy and unaware of it, emotionally numb and repressed and unaware of it, and didn’t ever manage my type 1 diabetes so I had a LOT of health issues there. I was stiff and uncomfortable and tense all the time, but never in a heart-racing way, in a lack of mental awareness way. I’d drink all the time. I always wanted to connect to others and feel things so incredibly badly, but I just couldn’t, no matter how hard I tried, and I was too disconnected from myself to even care to fix it.
My meds, for the first time in my life, make me FEEL things. I regulated my diabetes, I started eating healthy, I grew confident, both physically and mentally, I officially really love myself which is really cool, and best of all, every person I see on the street is a human being with a life and a story, and I feel sad with them when others cry, or feel delighted when they laugh, I stopped drinking even with people who WERE drinking, it was the best thing that ever happened to me. My brain felt focused and awake for the first time in a really long time, I was creative and passionate and happy!
But now, I’ve basically gone from 0 to 100. I’m having panic attacks, anxiety attacks, as of the past few weeks, my focus has been the worst it’s ever been in my life. I can’t even watch a movie with my friend or hang out with anyone. I’m so paranoid about my health that I break down basically every night. And my health IS failing. My vision is getting worse rapidly, I’m getting dizzy spells and shaking and intense dehydration and a consistently rapid heart. I had mood switches for no reason for my whole life, but now they are insane. I go from arrogant to thoughts of self-harm, have a mental freak out then immediately switch moods. I’m paranoid about having a seizure or a heart attack ALL the time, I overdo medicine and supplements, I’m not really leaving my house bc I get a sensory overload and feel weak and dizzy, I don’t see my friends anymore, and after a specific time during the day, I’m incredibly stressed.
So I’m in the hospital now. I have things to be tested lined up like anemia and hyperglycaemia and stuff, I’ve been here for so long that I’ve basically cycled through every emotion know to man. The whole week has felt like a fever dream.
I’m on a very high dose of long acting Dexedrine right now, part of me kinda knows it’s gotta change. I don’t want to go back to how I was. But I don’t want this. I wanna be a normal 50. I’m so tired of feeling nothing and now TOO much. I just want to be a normal, focused human being.

Hello, fellow narcs. I want to inform you of a serious medical condition I developed while being treated for narcolepsy It’s a long story so there’s a TLDR at the bottom; please read it if you or anyone you know is taking medication for ADHD.

It’s called rhabdomyolysis, here’s the link:

https://medlineplus.gov/ency/article/000473.htm

It’s something to be aware of, like serotonin syndrome with antidepressants. Not something to be scared of, as it’s only dangerous if it’s not addressed right away.

here is the link to report adverse side effects to the FDA: https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=reporting.home
edited for clarity and less dramatic wording
SO. It’s 2017. I was 19, excited to start Xyrem. I’d taken Vyvanse for several years (for ADHD) with no issues.
August 27, 2017, I got my first shipment and started my first week. It was amazing, I could probably write a novel on how different my brain felt when rested. I felt so normal and it made me nearly euphoric. Everything felt possible and I felt capable again.
7 days in, it started as a strange tingly pain in my legs one evening while standing in place. An hour later, my knees felt like something had burst inside; there was a sensation like icy water and they were red and swollen. The pain came in several forms: muscle spasms up and down my legs; a crushing, rolling sensation across my kneecaps; severe cramps that inhibited me from standing or walking; and painful muscle stiffness. If I held onto my knee and moved it left to right I felt something grinding that also could be felt by others. I called my mom and met up with her for ER Trip #1. At this point, I wasn’t scared of what was wrong (I consulted the internet and figured I tore or dislocated something), I was scared of how bad it was going to hurt when they fixed it and if I could maybe be put under while they moved whatever back in place.
They did an X-ray and bloodwork. The doctor came in, told me everything was fine, and wrote me a script for pain meds and crutches.
I was debilitated over the next few weeks and hospitalized many times as the condition worsened. It was a nightmare. Nobody could give me answers despite running every test they could think of; many doctors didn’t believe it was as excruciating as I said it was. It genuinely felt like someone was crushing my kneecaps, going back and forth over them with a steamroller, and stretching and snapping my muscles and tendons, especially my IT band. One hospital doctor told me it was psychosomatic and referred me to a therapist. (I am female and was 19-20 at the time.)
I stopped taking Xyrem because that seemed like the most logical cause. Nothing improved. I discontinued Vyvanse as well and nothing improved.
The pain spread to my upper back, shoulders, and elbows. I saw a physical therapist who noted how swollen my knees were and how atrophied my muscles had become (which makes no sense as I’ve always been fit and it had been less than a month since The Condition started at this point.)
After a month or so, I started taking my meds again since nothing got better and I couldn’t find anything online that sounded even remotely close to what I was experiencing. The pain was constant torture and never had any sort of rhythm or predictability about it.
I noticed one day I wasn’t urinating much and that my urine was dark. I went to the ER and mentioned other symptoms I had assumed were stress: tachycardia (resting hr over 160), nausea, vomiting; my legs were puffy and ached.
They ran tests, told me I had anemia, (no prior history) and that I was just dehydrated. The IV caused increased muscle pain and I asked the doctor to check my kidney function. He told me I was fine and discharged me; I went home.
I thought I was going to die that night, it was that deep sort of primal instinct/feeling that something was wrong. I was too afraid to take any medication because I was convinced it HAD to be meds, despite not having evidence.
That was December 2017. After two months of no meds, the mysterious muscle condition seemed to have gotten a bit better. I could walk across my apartment without braces, crutches, the broken swivel chair, or having to sit down. I wasn’t in constant pain and the pain I did experience was NOTHING compared to how it had been at the peak of it’s severity. Like, it was still bad enough I had to chew on ice and go to my mental happy place, but I didn’t fantasize about amputating my legs anymore.
I began Xyrem again. No problems, the pain stayed consistently manageable and I decided Xyrem was safe to keep taking. (It was, thank god.) I still didn’t know what happened to my body. (It still hasn’t gone back to normal, I still experience pain and can’t do as much as I used to. I’m only 22.)
So a month ago, my new prescriber wrote me a script for 10 mg Vyvanse (for narcolepsy and ADHD, I was planning on going back to school, finally). I was a little nervous but figured, okay, it’s literally a pediatric dose. The Condition is getting better and was probably some one-time freak medical mystery.
Within a week of taking Vyvanse, I felt it beginning exactly as it had the first time, tingly legs, sore knees, cold sensation. I had a panic attack, felt absolutely sick with terror and grief (I depend on stimulants quite a lot and can’t work or go to school without them) and went back to fervently researching via the internet.
And I found it. On this website, the FDA website, and a few other ones:
www.aboutlawsuits.com/adhd-drugs-rhabdomyolysis-warning-82002/
It’s called rhabdomyolysis, it’s extremely rare, and was only added to the warning label in 2015, which explains why doctors didn’t think of it during my battery of tests and examinations.
It applies to ALL ADHD MEDICATIONS, this includes Strattera. It is a life-threatening condition and if you begin experiencing symptoms, contact your doctor IMMEDIATELY.
Here is what is published on the site:
“Rhabdomyolysis is a side effect associated with several different types of medications, which causes muscle fibers to begin to break down, releasing a protein called myoglobin, which can damage the kidneys as they attempt to filter it out of the bloodstream.
The illness is usually reported in patients over 65 years of age or those who have renal impairment or uncontrolled hypothyroidism, however these drugs are prescribed heavily to children and young adults. Over time, rhabdomyolysis can lead to kidney damage and even kidney failure. Some may require dialysis or a kidney transplant.
The list of drugs that must now carry the rhabdomyolysis warning includes Adderall, Adderall XR, Concerta, Daytana, Desoxyn, Dexedrine, Focalin, Focalin XR, metadate CD, Methylin, Quillivant XR, Ritalin, Ritalin LA, Ritalin SR, Strattera and Vyvanse.”
I’m writing this because back in 2017, I came HERE looking for answers. I messaged with a few other people who had the same exact symptoms. I don’t have my old account anymore, so I can’t check up on them, but I wanted to check up on all of you and bring more attention to this.
Sorry for the long post; take good care of yourselves, stay vigilant and knowledge about your health and medication.
love u

TLDR:For some reason, after starting a new med, the stimulant I’d taken for years caused a life-threatening condition called rhabdomyolysis. Basically, it dissolves your skeletal muscles resulting in a protein being released into your bloodstream. This can cause kidney damage or failure and long term muscle pain/weakness.

Stimulants can cause non-serious muscle cramps, especially if you’re dehydrated, and rhabdomyolysis is extremely rare.

You can ask to get tested for it if you think you have symptoms.

https://medlineplus.gov/ency/article/000473.htm

tl;dr: Do any of you feel tired/lethargic all the time? And do your meds help?
So I was diagnosed half a year ago and have been trying different meds since then. One of my main problems (this has existed for as long as I can remember, before I just thought it was a problem with my sleep) is that I'm almost always feeling tired or lethargic. Doing anything, even the stuff that I like, feels like a chore. It doesn't really matter if I sleep more, but it does get a lot worse if I get less than 5-6 hours of sleep (I guess most people have that problem though). I've been tested various times for conditions like anemia or hypothyroidism, but nothing seems to be wrong. It was first after I got diagnosed that I began thinking it could be because of ADHD, but I haven't been able to find much info about it. Haven't really found any meds that deal with this problem yet. Ritalin helps though. Strattera makes it worse, guanfacine makes it worse. Dexedrine doesn't really affect it. Haven't tried Adderal.
My question is, do any of you feel tired or lethargic a lot of the time, and is it because of ADHD?

Hi all. I was diagnosed with ADHD as a kid and diagnosed again with ADHD Primarily Inattentive Type recently. It's made my life and everyday living really difficult. I'm always losing things from room to room, leaving important things on the bus, forgetting to turn the oven off, forgetting to lock the doors, and forgetting to let the dogs inside (even when I set a timer, I'll go upstairs and forget I set it.) Trying to start anything productive feels like an insurmountable task. I always have to go back when I'm reading several times or when I'm watching tv; it takes me an hour to watch a half-hour show. It's interfered in both my romantic relationships and my education. In college I always had trouble doing things by the deadline. I kept staying up all night trying to complete assignments the night before they were due and it would give me horrible panic attacks that sent me to the ER. Eventually I had to medically withdraw from college, and I haven't been back in 5 years.
Over the past 2 years I've prioritized trying to find a medication that works for me, and I'm so frustrating that nothings works for me after several doses of several different medications. Adderall seemed to do nothing for me at 5 or 10 mg, and at 15 mg it just gave me a calm and sleepy sensation. Ritalin made me experience depersonalization and derealization at the smallest dose, made it hard to initiate conversations with people, and made my concentration problems even worse; it was like I was constantly walking through taffy. Vyvanse did nothing for me at lower doses, but at a higher dose it had the same effects as Ritalin. Wellbutrin and Guanfacine both did nothing at all, but had no side effects either. I haven't taken Dexedrine in a long time, but it took away my appetite back when I was in junior high school to the point where I was dangerously thin, and didn't help my concentration. I haven't taken Straterra since high school, it didn't do anything back then, and I won't take it again because it only comes in gelatin capsules in my country and I'm a vegetarian. I don't remember Clonodine helping at all, but I haven't taken it since 3rd grade. I've never felt like any medication has "lifted the fog" or even made anything less foggy, and whenever I hear other people's experiences that their medication has done that I feel like a starving puppy watching people eat through a restaurant window.
I've tried everything else I can think of to try to manage my symptoms. I eat a healthy and balanced diet of whole foods without excessive sugar and make sure to get enough Omega-3s and Vitamin D (I've started taking a Vitamin D supplement too, and my levels are normal.) I've never learned to drive (because I'm afraid of being distracted while driving) so I walk everywhere almost an hour every day and get a lot of exercise. 6 months ago I started strength training 3 days too, but it hasn't improved my symptoms. I sleep 8 to 9 hours a night and I've tried shifting to waking up consistently at a time that maximizes my productivity. I meditate daily, which has helped my anxiety but not my ADHD. My most effective strategies have been keeping a daily planner, prioritizing time management, cleaning the space around me, cutting the amount of tv I watch, keeping a checklist of daily habits I want to do, and trying to put everything in the same place, but even then I feel like I'm only a tenth as productive as everyone else and spend an hour every day trying to find things. I've also tried caffeine and edible marijuana just to see what would happen, but both make me even less focused and trigger panic attacks. I haven't used either at all in 3 years.
Since I'm unresponsive to medication, I've tested other medical issues to see if they could be the problem with both this and my excessive fatigue. My thyroid is completely normal. My hemoglobin is always high, but my ferritin is always low, so I'm seeing a specialist soon for anemia. I was diagnosed with Asperger's in junior high, but I don't know how that would change how I respond to medication.
I've been through 2 med providers in the past 2 years (who both left the practice) and just saw my third a week ago. She seemed stumped and just wanted to try me on an anti-depressant (Trintellix.) She thinks depression might be causing some of the symptoms considering I have a history of depressive episodes, but the only symptoms of depression I actually have right now are excessive fatigue and not being able to concentrate. It seems like she's throwing her hands in the air and has no idea what to do to help me. I'm at a loss of what to do. Should I try the anti-depressant for a few months and see what happens? Should I get a new med provider? Should I just drop out of medication therapy and give up the hope that anything will ever make this better for me?

Visible Symptoms
I have history of anemia, have been prescribed multiple types of amphetamine medication for 3+ years, currently on Dexedrine IR 40mg a day.
I experience Joint stiffness, intense headaches around temples, numb patches along top of the spine, Cold hands and feet, occasional complete numbness in one or more digits, blue skin, and sudden appearance of veins in palms accompanied with loose, thickened, wrinkly skin that hadn't been there before. I've also noticed a rapid growth of spider veins in my thighs, which could just be due to aging as my mom has many. I also occasionally experience deep flushing in my chest that sometimes spreads to my stomach, legs and shoulders.
I do have a family history of high blood pressure, diabetes, and if it's worth mentioning, paranoid schizophrenia (in case I'm severely overreacting...)
Many thanks to any and all responses! I am planning on seeing my physician soon, I just would like to cast out my worries of something serious, if possible, or plan to seek more urgent care if advised to do so. :)